Abstract: Systems and methods for automatically tracking multi-Z horizons within seismic volumes are provided. A surface from a plurality of surfaces identified at different depths for a multi-Z horizon within a seismic volume is selected. A seed point corresponding to the selected surface is determined. The selected surface is tracked over new data points through the seismic volume. Tracking each new data point involves comparing a depth of the new data point with depths associated with other surfaces and determining whether the depth of the new data point honors a geological boundary rule for maintaining a relative depth position of each of the plurality of surfaces within the multi-Z horizon, based on the comparison. When the depth of the new data point honors the rule, the selected surface is extended to include the new data point and, when it does not, the new data point is discarded.

Abstract: Systems and methods for automatically tracking multi-Z horizons within seismic volumes are provided. A surface from a plurality of surfaces identified at different depths for a multi-Z horizon within a seismic volume is selected. A seed point corresponding to the selected surface is determined. The selected surface is tracked over new data points through the seismic volume. Tracking each new data point involves comparing a depth of the new data point with depths associated with other surfaces and determining whether the depth of the new data point honors a geological boundary rule for maintaining a relative depth position of each of the plurality of surfaces within the multi-Z horizon, based on the comparison. When the depth of the new data point honors the rule, the selected surface is extended to include the new data point and, when it does not, the new data point is discarded.

Abstract: Embodiments of the invention provide a method for classifying seismic attributes, including generating data points by cross plotting seismic attributes from a first data volume and a second data volume, encompassing at least one of the generated data points within a polygon, generating a reference line, determining an interpolation direction relative to the reference line, and assigning an attribute value to the at least one generated data point encompassed within the polygon wherein the assigned attribute value is interpolated based on the combination of its position to the reference line along the interpolation direction and the shape of the polygon.

Abstract: Embodiments of the invention provide a method for classifying seismic attributes, including generating data points by cross plotting seismic attributes from a first data volume and a second data volume, encompassing at least one of the generated data points within a polygon, generating a reference line, determining an interpolation direction relative to the reference line, and assigning an attribute value to the at least one generated data point encompassed within the polygon wherein the assigned attribute value is interpolated based on the combination of its position to the reference line along the interpolation direction and the shape of the polygon.

Abstract: Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.

Abstract: RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.

Abstract: Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided.