Patents by Inventor Jocelyn Duen-Ya Jea

Jocelyn Duen-Ya Jea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM FOR REGULATING GENE EXPRESSION
    Publication number: 20220290147
    Abstract: Compositions and methods relating to regulation of gene expression are described. In some embodiments, the present disclosure provides compositions and methods for the regulation of gene expression using nucleic acid constructs. In some embodiments, the present disclosure recognizes the utility of alternative splicing in regulation of gene expression in a nucleic acid construct. In some embodiments, the present disclosure recognizes the utility of regulating gene expression utilizing ligand-binding aptamers.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Applicants: Baylor College of Medicine, Baylor College of Medicine
    Inventors: Laising Yen, Liming Luo, Jocelyn Duen-Ya Jea
  • CHIMERIC RNA-DRIVEN GENOMIC REARRANGEMENT IN MAMMALIAN CELLS
    Publication number: 20210238592
    Abstract: Embodiments of the disclosure include methods and compositions in which two inter-chromosomal or intra-chromosomal genomic DNA regions are rearranged upon exposure of the genomic DNA to a chimeric RNA that produces fusion of the two regions. The chimeric RNA hybridizes to the two different parts of the genomic DNA and forms a DNA/RNA hybrid in a sequence-specific manner, thereby facilitating genomic rearrangement. In particular embodiments this mechanism is utilized to produce directed gene fusion in targeted genomic DNA regions.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 5, 2021
    Inventors: Laising Yen, Sachin Kumar Gupta, Jocelyn Duen-Ya Jea