Abstract: An absorbent article that helps maintain a wearer's skin pH in an acidic condition is described. The absorbent article has a body contacting surface with a skin care composition that is transferred from the body contacting surface to the wearer's skin by contact, normal wearer motion and/or body heat. The skin care composition contains at least one proton donating active. Preferred proton donating actives include: monomeric organic acids, polymeric acids, and inorganic acid salts. The absorbent article also includes a liquid impermeable backsheet and an absorbent core positioned between the body contacting surface and the backsheet.

Abstract: Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said treatment; and administering an estrogen hormone to said subject at a level of from about 0.2 to about 0.8 LED per day of said treatment. The bone-active phosphonate is preferably a bisphosphonate, or a phosphonoalkyl phosphonate.

Abstract: The present invention provides an applicator for applying and distributing a substance onto a target surface. The applicator comprises a substantially planar sheet of compressible, conformable material having opposed first and second surfaces and an interior region between said first and second surfaces. The sheet of material has a thickness between the first and second surfaces which decreases when the sheet of material is subjected to an externally-applied force in a direction substantially normal to the first surface. The applicator further includes at least one discrete reservoir extending inwardly of the first surface into the interior of the sheet of material which is at least partially filled with a substance and at least one discrete aperture formed in the first surface which is in fluid communication with the reservoir.