Abstract: A probe contacts targeted tissue, sometimes while positioned adjacent to nontargeted live tissues. In preferred forms, the probe includes a support that only minimally conducts heat from nontargeted tissues. A very conductive targeted-tissue-contacting element, at an end of the support, is immersed in a liquid cryogen (preferably nitrogen) and then removed for contacting with (e. g., insertion into) the targeted tissue. An ultrathin highly thermoconductive polymeric tubing holds both a very conductive, cold material, forming the targeted-tissue-contacting element, and fine insulating material (e. g. highly insulating elastomer) forming part of the support. The targeted-tissue-contacting element is fashioned to fit the targeted tissue in at least one dimension, and the support to fit nontargeted live tissues (if any) adjacent to which the probe is positioned while contacting the targeted tissue.

Abstract: A method for increasing the damage to targeted cells to the point of rupture during freezing while minimizing the freezing of nearby non-targeted tissues comprising: inducing a hyperosmotic condition in the targeted tissue; bloating the targeted tissue; freezing the targeted tissue to cause increase of damage to the targeted tissue to the point of rupture while minimizing freezing of nearby non-targeted tissues.

Abstract: Devices and method for freezing of tissues. Devices comprise a cryosurgical probe that can be very slim with diameter up to a fraction of a millimeter for very focal freezing application, and an insulating canula for adjusting freeze zone. A cryosurgical probe with solid and liquid cold sources, wherein the solid cold source forms the portion of the probe inserted to tissue for thermal exchange while the liquid cold source maintains the operating temperature of said solid cold source. Method for rupturing targeted cells during freezing while minimizing freezing of nearby tissues and vasculatures.