Patents by Inventor Jocelyn Holash

Jocelyn Holash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS, COMPOSITIONS, AND KITS FOR TREATMENT OF CANCER
    Publication number: 20200308286
    Abstract: Provided herein are the use of FGFR3 inhibitors and taxanes to treat solid and hematologic cancers, as well as compositions and kits comprising an FGFR3 inhibitor and a taxane.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 1, 2020
    Inventor: Jocelyn Holash
  • METHODS, COMPOSITIONS, AND KITS FOR TREATMENT OF CANCER
    Publication number: 20180222983
    Abstract: Provided herein are the use of FGFR3 inhibitors and taxanes to treat solid and hematologic cancers, as well as compositions and kits comprising an FGFR3 inhibitor and a taxane.
    Type: Application
    Filed: February 6, 2018
    Publication date: August 9, 2018
    Inventor: Jocelyn HOLASH
  • METHODS, COMPOSITIONS, AND KITS FOR TREATMENT OF CANCER
    Publication number: 20160243228
    Abstract: Provided herein are the use of FGFR3 inhibitors and PD1 inhibitors to treat solid and hematologic cancers and compositions and kits comprising an FGFR3 inhibitor and a PD1 inhibitor.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 25, 2016
    Inventors: Jocelyn HOLASH, Stephen LAU
  • Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof
    Patent number: 8388963
    Abstract: This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: March 5, 2013
    Assignees: Aventis Pharma SA, Regeneron Pharmaceuticals Inc
    Inventors: Patricia Vrignaud, Marielle Chiron-Blondel, Marie-Christine Bissery, Eric Furfine, Jocelyn Holash, Jesse M. Cedarbaum
  • ANTITUMOR COMBINATIONS CONTAINING A VEGF-INHIBITING AGENT AND 5FU OR A DERIVATIVE THEREOF
    Publication number: 20090285841
    Abstract: This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
    Type: Application
    Filed: July 24, 2009
    Publication date: November 19, 2009
    Applicants: AVENTIS PHARMA SA, REGENERON PHARMACEUTICALS INC.
    Inventors: Patricia VRIGNAUD, Marielle CHIRON-BLONDEL, Marie-Christine BISSERY, Eric FURFINE, Jocelyn HOLASH, Jesse M. CEDARBAUM
  • Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
    Patent number: 7449182
    Abstract: Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: November 11, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jesse M. Cedarbaum, Jocelyn Holash
  • Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
    Publication number: 20080145363
    Abstract: Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
    Type: Application
    Filed: December 14, 2007
    Publication date: June 19, 2008
    Inventors: Jesse M. Cedarbaum, Jocelyn Holash
  • Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
    Patent number: 7354581
    Abstract: Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: April 8, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jesse M. Cedarbaum, Jocelyn Holash
  • Method of treating cancer with a VEGF antagonist and an anti-proliferative agent
    Patent number: 7354579
    Abstract: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, such as a VEGF trap, an anti-proliferative agent, such as taxol, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: April 8, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jocelyn Holash, Robert Jaffe, Limin Hu, George D. Yancopoulos
  • Method of tumor regression with VEGF inhibitors
    Patent number: 7354578
    Abstract: Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: April 8, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jessica Kandel, Jocelyn Holash, Darrell Yamashiro, Jianzhong Huang, George Yancopoulos, John Rudge
  • Use of VEGF antagonists for the treatment of malignant gliomas
    Patent number: 7354582
    Abstract: Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human patient. The VEGF inhibitor is a VEGF antagonist protein comprising a dimeric protein having two fusion polypeptides having the sequence of SEQ ID NO:2.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: April 8, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: W. K. Alfred Yung, Candelaria Gomez-Manzano, Juan Fueyo, Jesse M. Cedarbaum, Jocelyn Holash
  • Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)
    Patent number: 7351411
    Abstract: Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor Flt1 and Ig domain 3 of the VEGF receptor Flk1 or Flt4, and a multimerizing component. Further included are methods of preventing anemia, increasing hematocrit levels, and increasing or stimulating erythropoietin, particularly in subjects being treated for cancer with chemotherapeutic agents and/or radiation.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: April 1, 2008
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jocelyn Holash, Jesse M. Cedarbaum, John Rudge, George D. Yancopoulos, Neil Stahl
  • Use of VEGF antagonists for the treatment of malignant gliomas
    Publication number: 20070212354
    Abstract: Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human patient. The VEGF inhibitor is a VEGF antagonist protein comprising a dimeric protein having two fusion polypeptides having the sequence of SEQ ID NO:2.
    Type: Application
    Filed: March 10, 2006
    Publication date: September 13, 2007
    Inventors: W.K. Yung, Candelaria Gomez-Manzano, Juan Fueyo, Jesse Cedarbaum, Jocelyn Holash
  • Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)
    Publication number: 20060210566
    Abstract: Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor Flt1 and Ig domain 3 of the VEGF receptor Flk1 or Flt4, and a multimerizing component. Further included are methods of preventing anemia, increasing hematocrit levels, and increasing or stimulating erythropoietin, particularly in subjects being treated for cancer with chemotherapeutic agents and/or radiation.
    Type: Application
    Filed: March 10, 2006
    Publication date: September 21, 2006
    Inventors: Jocelyn Holash, Jesse Cedarbaum, John Rudge, George Yancopoulos, Neil Stahl
  • Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
    Publication number: 20060183684
    Abstract: Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
    Type: Application
    Filed: February 8, 2006
    Publication date: August 17, 2006
    Inventors: Jesse Cedarbaum, Jocelyn Holash
  • Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof
    Publication number: 20060178305
    Abstract: This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
    Type: Application
    Filed: December 2, 2005
    Publication date: August 10, 2006
    Applicant: Aventis Pharma S.A.
    Inventors: Patricia Vrignaud, Marielle Chiron-Blondel, Marie-Christine Bissery, Eric Furfine, Jocelyn Holash, Jesse Cedarbaum
  • Use of a VEGF antagonist in combination with radiation therapy
    Publication number: 20050196340
    Abstract: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, in combination with radiation therapy and/or a therapeutic radiopharmaceutical.
    Type: Application
    Filed: November 29, 2004
    Publication date: September 8, 2005
    Inventors: Jocelyn Holash, George Yancopoulos, Phyllis Wachsberger, Adam Dicker, Randy Burd
  • Use of a VEGF antagonist in combination with radiation therapy
    Publication number: 20050112061
    Abstract: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) trap, in combination with radiation therapy and/or a therapeutic radiopharmaceutical.
    Type: Application
    Filed: July 30, 2004
    Publication date: May 26, 2005
    Inventors: Jocelyn Holash, George Yancopoulos, Phyllis Wachsberger, Adam Dicker, Randy Burd
  • Composition of a VEGF antagonist and an anti-proliferative agent
    Publication number: 20050032699
    Abstract: Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, such as a VEGF trap, an anti-proliferative agent, such as taxol, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: July 23, 2004
    Publication date: February 10, 2005
    Inventors: Jocelyn Holash, Robert Jaffe, Limin Hu, George Yancopoulos
  • Method of tumor regression with VEGF inhibitors
    Publication number: 20040265309
    Abstract: Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.
    Type: Application
    Filed: June 4, 2004
    Publication date: December 30, 2004
    Inventors: Jessica Kandel, Jocelyn Holash, Darrell Yamashiro, Jianzhong Huang, George Yancopoulos, John Rudge