Patents by Inventor Jochen Buhler

Jochen Buhler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Whole proteome tiling microarrays
    Patent number: 8658572
    Abstract: The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: February 25, 2014
    Assignee: Roche NimbleGen, Inc.
    Inventors: Tom Albert, Todd Richmond, Matthew Rodesch, Klaus-Peter Stengele, Jochen Bühler
  • WHOLE PROTEOME TILING MICROARRAYS
    Publication number: 20120245057
    Abstract: The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.
    Type: Application
    Filed: March 13, 2012
    Publication date: September 27, 2012
    Inventors: Tom Albert, Todd Richmond, Matthew Rodesch, Klaus-Peter Stengele, Jochen Buhler
  • METHODS FOR SYNTHESIS OF AN OLIGOPEPTIDE MICROARRAY
    Publication number: 20120238477
    Abstract: An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm2.
    Type: Application
    Filed: March 13, 2012
    Publication date: September 20, 2012
    Inventors: Tom Albert, Todd Richmond, Matthew Rodesch, Klause-Peter Stengele, Jochen Bühler, Markus Ott