Patents by Inventor Jochen Gätgens

Jochen Gätgens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing recombinant proteins with a constant content of pCOin the medium
    Patent number: 8460895
    Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: June 11, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Detlef Eisenkraetzer, Jochen Gaetgens, Alexander Jockwer, Christian Klinger, Thomas Noll, Barbara Bezdek-Sueess
  • METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM
    Publication number: 20110159539
    Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.
    Type: Application
    Filed: March 11, 2009
    Publication date: June 30, 2011
    Inventors: Detlef Eisenkraetzer, Alexander Jockwer, Christian Klinger, Jochen Gaetgens, Thomas Noll, Barbara Bezdek-Sueess
  • Glycosylation using GalNac-T4 transferase
    Patent number: 6465220
    Abstract: The use of human polypeptide N-acetylgalactosaminytransferase T-4 (GalNAc-T4) to glycosylate substrates is disclosed. The action of GalNAc-T4 can complement the activities of GalNAc-T1, -T2 and -T3. The glycosylated substrates are useful in preparation of vaccines and anti-inflammatory agents. A method of producing the soluble form of the enzyme is also disclosed.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 15, 2002
    Assignee: GlycoZym ApS
    Inventors: Frau Helle Hassan, Henrik Clausen, Eric Paul Bennett, Detlef Eisenkrätzer, Jochen Gätgens