Abstract: A classifying device for classifying cells in real-time, comprising: as alignment unit configured to align a cell to be classified along the cell's major axis; and a classifying unit configured to classify the aligned cell using a multilayer perceptron, MLP; wherein the MLP classifies the aligned cell based on one or more images of the aligned cell. By executing the classifying device, an improved and efficient cell classification in real-time based on cell images can be provided, while labelling of the cells to be classified can be avoided.

Abstract: A classifying device for classifying cells in real-time, comprising: as alignment unit configured to align a cell to be classified along the cell's major axis; and a classifying unit configured to classify the aligned cell using a multilayer perceptron, MLP; wherein the MLP classifies the aligned cell based on one or more images of the aligned cell. By executing the classifying device, an improved and efficient cell classification in real-time based on cell images can be provided, while labelling of the cells to be classified can be avoided.

Abstract: Some embodiments include a device for managing end-to-end connections of a network including a plurality of end-to-end connections with assigned queues including a data flow having data packets to be transmitted collectively comprising: a processor; a state unit to provide a current status of a quality of service parameter of a queue to which a new data flow is to be allocated; a resource allocation unit to allocate the new data flow to the queue based on a threshold for the quality of service parameter for the queue and the current status of the quality of service parameter of the queue; and a routing unit to route the data packets of the new data flow based on the allocation.

Abstract: The present invention relates to a method and an apparatus for sorting cells. The apparatus for determining the mechanical properties of cells comprises: —a microfluidic channel having an inlet and an outlet, the channel being configured to let a fluid containing cells pass therethrough, —a means for introducing a fluid containing cells into the channel so as to establish a flow of the fluid within the channel, —a cell shape measurement device arranged to obtain information of a deformed shape of a cell deformed due to the flow pattern created by the interaction of the fluid flow with the channel, and —an analysis means arranged to use data from the cell shape measurement device to obtain mechanical properties of the cells.

Abstract: Some embodiments include a device for managing end-to-end connections of a network including a plurality of end-to-end connections with assigned queues including a data flow having data packets to be transmitted collectively comprising: a processor; a state unit to provide a current status of a quality of service parameter of a queue to which a new data flow is to be allocated; a resource allocation unit to allocate the new data flow to the queue based on a threshold for the quality of service parameter for the queue and the current status of the quality of service parameter of the queue; and a routing unit to route the data packets of the new data flow based on the allocation.

Abstract: Managing end-to-end connections of a network includes estimating a load of network resources, and providing a quality of service status of the network. Quality of service parameters within the network are pre-calculated based on the load of the network resources and the quality of service status of the network, and the network resources are pre-allocated based on the pre-calculated quality of service parameters. Data packets are routed based on the pre-allocated network resources.

Abstract: In a method for diagnosing and/or prognosis of cancers, diagnosing origin of tumor cells, optimizing cancer therapy, and screening active substances for oncology, the mechanical properties of tumor cells and reference cells are analyzed under mechanical load that causes linear or non-linear deformation of the loaded cell. The engineering strain of the cells caused by directed mechanical stress being introduced is used to determine metastasis risk and the presence of uncontrollably proliferating and/or invasive cells, or the origin of the tumor. The metastasis risk is determined based on the proportion of cells in the sample exhibiting engineering strain in a direction opposite to the stressing direction. The risk of the presence of uncontrollably proliferating cells for non-linear deformation of the cell is determined in the sample based on the mean value of the engineering strain in the direction of cell stressing.

Abstract: The present invention relates to a method and an apparatus for sorting cells. The apparatus for determining the mechanical properties of cells comprises: —a microfluidic channel having an inlet and an outlet, the channel being configured to let a fluid containing cells pass therethrough, —a means for introducing a fluid containing cells into the channel so as to establish a flow of the fluid within the channel, —a cell shape measurement device arranged to obtain information of a deformed shape of a cell deformed due to the flow pattern created by the interaction of the fluid flow with the channel, and —an analysis means arranged to use data from the cell shape measurement device to obtain mechanical properties of the cells.

Abstract: In a method for diagnosing and/or prognosis of cancers, diagnosing origin of tumor cells, optimizing cancer therapy, and screening active substances for oncology, the mechanical properties of tumor cells and reference cells are analyzed under mechanical load that causes linear or non-linear deformation of the loaded cell. The engineering strain of the cells caused by directed mechanical stress being introduced is used to determine metastasis risk and the presence of uncontrollably proliferating and/or invasive cells, or the origin of the tumor. The metastasis risk is determined based on the proportion of cells in the sample exhibiting engineering strain in a direction opposite to the stressing direction. The risk of the presence of uncontrollably proliferating cells for non-linear deformation of the cell is determined in the sample based on the mean value of the engineering strain in the direction of cell stressing.

Abstract: A method for diagnosis and/or prognosis of cancers, for diagnosis of the site of origin of tumour cells, for optimizing the treatment of cancer patients and for screening active substances for oncology. In the method, the mechanical properties of tumour cells and reference cells are analyzed under a mechanical load that leads to linear or nonlinear deformation of the respective loaded cell. The expansion of the cells, which results from the input of a directed mechanical stress, is used to determine the risk of tumour metastases and, if appropriate, the presence of uncontrollably proliferating and/or invasive cells, or the tissue of origin of the tumour. The risk of tumour metastases is determined on the basis of the proportion of cells in the sample that have an extension counter to the direction of stressing.

Abstract: The invention relates to a device for contactless manipulation and alignment of sample particles in a measurement volume using a nonhomogeneous electric alternating field, comprising a radiation source for emitting electromagnetic radiation and optical means for guiding the electromagnetic radiation into the measurement volume.

Abstract: The invention relates to a device for contactless manipulation and alignment of sample particles in a measurement volume using a nonhomogeneous electric alternating field, comprising a radiation source for emitting electromagnetic radiation and optical means for guiding the electromagnetic radiation into the measurement volume.