Abstract: A connecting piece having a transfer apparatus for data transfer and/or for transferring electrical energy with the counter connecting piece. A connecting piece of this type is preferably used in an intelligent medical fluid conduction and transfer system, in which various components are interconnected by means of the connecting pieces not only fluidically but also for the purpose of transferring energy and/or data with each other, such that, for example, information regarding the medication can be exchanged or validated.

Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract: The present invention provides biomarkers and a method for differentiating between NASH and NAFLD in a subject.

Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract: The present invention provides biomarkers and a method for diagnosing a liver disease in a subject such as steatosis, inflammatory liver disease, NASH, and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a liver disease in a subject and a method of differentiating between NASH and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract: The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.

Abstract: The invention provides a method of identifying a compound useful for treatment of IBD which comprises assaying the compound for its ability to modulate the activity or amount of 3OST4. The assay is selected from measurement of 3OST4 activity using a cell line which expresses 3OST4 or using purified 3OST4 protein, and measurement of 3OST4 transcription or translation in a cell line expressing 3OST4. The invention also provides a method of preparing a pharmaceutical composition, a diagnostic method for the determination of susceptibility to IBD, a method for the diagnosis of IBD or a predisposition thereto and use of a compound able to modulate the activity or amount of 3OST4 in preparation of a medicament for the treatment of IBD.

Abstract: The invention relates to a method for detecting non-responders to anti-TNF therapy comprising testing an individual for homozygosity for a single nucleotid polymorphism in the gene coding for the TNF Receptor II. Monoclonal antibodies against TNF-&agr; (infliximab) represent a new treatment for steroid refractory Crohn's disease that result in a remission rate of 30-50% after 4 weeks. Known single nucleotid polymorphisms within the TNF Receptor I and TNF Receptor II were tested for association with the response to the therapy. It was found that individuals homozygote for the mutated allele arginine at amino acid position +196 in the TNF Receptor II or the mutated allele in exon 2 at amino acid position 56 did not respond. Polymorphisms in exon 2 was newly found. None of the individuals homozygote for the mutations in exons 2 or 6 responded. The mutation in exon 2, although a silent mutation, can be used as a marker because it is in a high linkage disequilibrium with the mutation in exon 6.