Patents by Inventor Jochen Ittner

Jochen Ittner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying potential therapeutic agents for treatment of osteoporosis using mitogenic indices
    Patent number: 6713269
    Abstract: A method of screening potential therapeutic substances that may be useful in the treatment of osteoporosis is provided herein utilizing primary osteoblast precursor cell cultures to determine the mitogenic effect of the tested agents. This method comprises preparation of the primary cultures from osteoporotic patients for the expression of several intracellular proteins in early and late osteoblast differentiation phases, expression of other proteins involved in matrix synthesis, and quantitative analysis of the cellular proliferation rate. The expression of such intracellular proteins and cell proliferation in the cultures derived from osteoporotic patients are quantitatively compared to primary osteoblast cell cultures from non-osteoporotic patients that are standardized for the same approximate age and sex.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: March 30, 2004
    Assignee: co.don Aktiengesellschaft
    Inventors: Olivera Josimovic-Alasevic, Karl-Gerd Fritsch, Jochen Ittner
  • Methods for Identifying Potential Therapeutic Agents for Treatment of Osteoporosis Using Mitogenic Indices
    Publication number: 20020076730
    Abstract: A method of screening potential therapeutic substances that may be useful in the treatment of osteoporosis is provided herein utilizing primary osteoblast precursor cell cultures to determine the mitogenic effect of the tested agents. This method comprises preparation of the primary cultures from osteoporotic patients for the expression of several intracellular proteins in early and late osteoclast differentiation phases, expression of other proteins involved in matrix synthesis, and quantitative analysis of the cellular proliferation rate. The expression of such intracellular proteins and cell proliferation in the cultures derived from osteoporotic patients are quantitatively compared to primary osteoblast cell cultures from non-osteoporotic patients that are standardized for the same approximate age and sex.
    Type: Application
    Filed: March 27, 1998
    Publication date: June 20, 2002
    Applicant: Co.don Aktiengesellschaft
    Inventors: Olivera JOSIMOVIC-ALASEVIC , Karl-Gerd FRITSCH , Jochen ITTNER