Patents by Inventor Jochen Keupp

Jochen Keupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10794976
    Abstract: A method of employing a central computer database (18) for supporting a characterization of tissue by magnetic resonance fingerprinting measurements, includes: exciting nuclei of a subject of interest by applying (50) a radio frequency excitation field B1 generated according to a magnetic resonance fingerprinting sequence (38), acquiring (52) magnetic resonance imaging signal data from radiation emitted by excited nuclei of the subject of interest, transferring (54) a magnetic resonance fingerprinting data set (42) to the central computer database (18), retrieving (56) a predefined dictionary from the central computer database (18), matching (60) the acquired magnetic resonance imaging signal data to the retrieved dictionary by applying a pattern recognition algorithm to determine a value (40) or a set of values (40) for at least one physical quantity (T1, T2), adding (62) at least the determined value (40) or the determined set of values (40) as a new entry of an associated medical data set (36) to the centr
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: October 6, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Thomas Erik Amthor, Sascha Krueger, Mariya Ivanova Donevea, Peter Koken, Julien Senegas, Jochen Keupp, Peter Boernert
  • Publication number: 20200250829
    Abstract: The invention provides for a medical instrument (100, 300, 400) comprising: a memory (110) for storing machine executable instructions (112) and a processor (106) for controlling the medical instrument.
    Type: Application
    Filed: August 30, 2018
    Publication date: August 6, 2020
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: BERNHARD GLEICH, JORN BORGERT, JOCHEN KEUPP
  • Patent number: 10451692
    Abstract: A dual- or multi-resonant RF/MR transmit and/or receive antenna (1, 2) especially in the form of a planar antenna or a volume array antenna (also called antenna array) is used for MR image generation of at least two different nuclei like e.g. 1H, 19F, 3He, 13C, 23Na or other nuclei having different Larmor frequencies. The antenna is coupled by an inductive coupling device (LI) with related transmit/receive channels (T/R). By such an inductive coupling, the tuning and matching of the antenna at the different resonant frequencies is easier than in case of a galvanic connection. The dual- or multi-resonant RF/MR transmit and/or receive antenna is used in an MR imaging apparatus.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: October 22, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Christoph Leussler, Peter Mazurkewitz, Jochen Keupp
  • Publication number: 20190285711
    Abstract: The invention provides for a magnetic resonance imaging system (100) comprising a memory (134) for storing machine executable instructions (140) and pulse sequence commands (142). The pulse sequence commands are configured for controlling the magnetic resonance imaging system according to a DCE Magnetic Resonance Imaging protocol. The magnetic resonance imaging system further comprises a user interface (200) and a processor (130) for controlling the magnetic resonance imaging system.
    Type: Application
    Filed: November 23, 2016
    Publication date: September 19, 2019
    Inventors: JOCHEN KEUPP, JAN JAKOB MEINEKE, KARSTEN SOMMER
  • Patent number: 10345407
    Abstract: The invention provides for a method of operating a magnetic resonance system for acquiring magnetic resonance data (152) from a phantom (124) within a measurement (zone 108). The phantom comprises a known volume of at least one predetermined substance ((128), 130). The method comprises the step of acquiring (300) the magnetic resonance data by controlling the magnetic resonance system with pulse sequence instructions (150). The pulse sequence instructions cause the magnetic resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence instructions specify a train of pulse sequence repetitions. Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 9, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Peter Boernert, Mariya Ivanova Doneva, Thomas Erik Amthor, Peter Koken, Jochen Keupp
  • Patent number: 10321845
    Abstract: The invention provides for a magnetic resonance imaging system (100) which comprise a magnet (104) and a magnetic field gradient generator (110, 112) for generating a gradient magnetic field within an imaging zone (108). The gradient magnetic field is aligned with a predetermined direction. The magnetic resonance imaging system further comprise a memory (134, 136) for storing machine executable instructions (150, 152, 154), a pre-calculated magnetic resonance fingerprinting dictionary (144), and pulse sequence instructions (140). The pulse sequence instructions cause the magnetic resonance imaging system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The magnetic resonance fingerprinting technique encodes the magnetic resonance data as slices (125).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: June 18, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Thomas Erik Amthor, Mariya Ivanova Doneva, Peter Koken, Jochen Keupp, Peter Boernert
  • Patent number: 10275886
    Abstract: A medical imaging system (5) includes a workstation (20), a coarse segmenter (30), a fine segmenter (32), and an enclosed tissue identification module (34). The workstation (20) includes at least one input device (22) for receiving a selected location as a seed in a first contrasted tissue type and a display device (26) which displays a diagnostic image delineating a first segmented region of a first tissue type and a second segmented region of a second contrasted tissue type and identified regions which include regions fully enclosed by the first segmented region as a third tissue type. The coarse segmenter (30) grows a coarse segmented region of coarse voxels for each contrasted tissue type from the seed location based on a first growing algorithm and a growing fraction for each contrasted tissue type.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: April 30, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Astrid Ruth Franz, Stefanie Remmele, Jochen Keupp
  • Patent number: 10241182
    Abstract: A magnetic resonance imaging system (1) includes at least one processor (28) configured to receive (48) diffusion weighted imaging data based on a diffusion weighted imaging sequence with magnetic gradient fields applied in different directions and with different b-values. The at least one processor (28) is further configured to detect (50) motion corrupted data present in the received imaging data based on a comparison of data redundant in the received data, and substitute (52) alternative data for detected motion corrupted data.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 26, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Christian Stehning, Thomas Perkins, Julien Senegas, Jochen Keupp
  • Patent number: 10175332
    Abstract: A method of MR imaging a moving portion of a body includes detecting a motion signal from the body while continuously subjecting the moving portion of the body to one or more preparation RF pulses; subjecting the moving portion of the body to an imaging sequence including an excitation RF pulse and switched magnetic field gradients, wherein the imaging sequence is triggered by the detected motion signal; acquiring MR signals from the moving portion of the body; and reconstructing an MR image from the acquired MR signals.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: January 8, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Jochen Keupp
  • Publication number: 20180031653
    Abstract: The invention provides for a method of operating a magnetic resonance system for acquiring magnetic resonance data (152) from a phantom (124) within a measurement (zone 108). The phantom comprises a known volume of at least one predetermined substance ((128), 130). The method comprises the step of acquiring (300) the magnetic resonance data by controlling the magnetic resonance system with pulse sequence instructions (150). The pulse sequence instructions cause the magnetic resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence instructions specify a train of pulse sequence repetitions. Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles.
    Type: Application
    Filed: January 22, 2016
    Publication date: February 1, 2018
    Inventors: PETER BOERNERT, MARIYA IVANOVA DONEVA, THOMAS ERIK AMTHOR, PETER KOKEN, JOCHEN KEUPP
  • Publication number: 20170328973
    Abstract: A method of employing a central computer database (18) for supporting a characterization of tissue by magnetic resonance fingerprinting measurements, including steps of —exciting nuclei of a subject of interest by applying (50) a radio frequency excitation field B1 generated according to a magnetic resonance fingerprinting sequence (38), —acquiring (52) magnetic resonance imaging signal data from radiation emitted by excited nuclei of the subject of interest, —transferring (54) a magnetic resonance fingerprinting data set (42) to the central computer database (18), —retrieving (56) a predefined dictionary from the central computer database (18), —matching (60) the acquired magnetic resonance imaging signal data to the retrieved dictionary by applying a pattern recognition algorithm to determine a value (40) or a set of values (40) for at least one physical quantity (T1, T2), —adding (62) at least the determined value (40) or the determined set of values (40) as a new entry of an associated medical data set (3
    Type: Application
    Filed: November 16, 2015
    Publication date: November 16, 2017
    Inventors: THOMAS ERIK AMTHOR, SASCHA KRUEGER, MARIYA IVANOVA DONEVEA, PETER KOKEN, JULIEN SENEGAS, JOCHEN KEUPP, PETER BOERNERT
  • Publication number: 20170319097
    Abstract: The invention provides for a magnetic resonance imaging system (100) which comprise a magnet (104) and a magnetic field gradient generator (110, 112) for generating a gradient magnetic field within an imaging zone (108). The gradient magnetic field is aligned with a predetermined direction. The magnetic resonance imaging system further comprise a memory (134, 136) for storing machine executable instructions (150, 152, 154), a pre-calculated magnetic resonance fingerprinting dictionary (144), and pulse sequence instructions (140). The pulse sequence instructions cause the magnetic resonance imaging system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The magnetic resonance fingerprinting technique encodes the magnetic resonance data as slices (125).
    Type: Application
    Filed: October 30, 2015
    Publication date: November 9, 2017
    Inventors: THOMAS ERIK AMTHOR, MARIYA IVANOVA DONEVA, PETER KOKEN, JOCHEN KEUPP, PETER BOERNERT
  • Publication number: 20170315193
    Abstract: The invention provides for a magnetic resonance system (100) for acquiring a magnetic resonance data from a subject (118) within a measurement zone (108) according to a magnetic resonance fingerprinting technique. The pulse sequence comprises a train of pulse sequence repetitions (302, 304). Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse (306) chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles, and each pulse sequence repetition comprises a sampling event (310) at a sampling time chosen from a distribution of sampling times. Each pulse sequence repetition of the pulse sequence comprises a first 180 degree RF pulse (308) performed at a first temporal midpoint between the radio frequency pulse and the sampling event to refocus the magnetic resonance signal.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 2, 2017
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: THOMAS ERIK AMTHOR, MARIYA IVANOVA DONEVA, PETER KOKEN, JOCHEN KEUPP, PETER BOERNERT
  • Patent number: 9795693
    Abstract: Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: October 24, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Sander Langereis, Jochen Keupp, Holger Gruell, Dirk Burdinski, Danielle Beelen
  • Patent number: 9797973
    Abstract: Magnetic resonance examination system comprises displaceable carrier for supporting an object to be examined. The carrier can be moved over a two dimensional area. The magnetic resonance examination system is configured to acquire sets of magnetic resonance signals from the object for various positions of the carrier in the two dimensional area.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 24, 2017
    Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Peter Boernert, Jochen Keupp, Peter Koken, Kay Nehrke
  • Patent number: 9766313
    Abstract: The invention relates to a method of CEST or APT MR imaging of at least a portion of a body (10) placed in a main magnetic field B0 within the examination volume of a MR device. The method of the invention comprises the following steps: •a) subjecting the portion of the body (10) to a saturation RF pulse at a saturation frequency offset; •b) subjecting the portion of the body (10) to an imaging sequence comprising at least one excitation/refocusing RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body (10) as spin echo signals; •c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; •d) reconstructing a MR image and/or B0 field homogeneity corrected APT/CEST images from the acquired MR signals.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: September 19, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Eggers, Jochen Keupp
  • Patent number: 9733328
    Abstract: The invention relates to a method of MR imaging of at least a portion of a body (10) of a patient placed in an examination volume of a MR device (1), the method comprising the steps of: —subjecting the portion of the body (10) to a first imaging sequence for acquiring a first signal data set (21); —subjecting the portion of the body (10) to a second imaging sequence for acquiring a second signal data set (23), wherein the imaging parameters of the second imaging sequence differ from the imaging parameters of the first imaging sequence; —reconstructing a MR image from the second signal data set (23) by means of regularization using the first signal data set (21) as prior information. Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: August 15, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Mariya Ivanova Doneva, Stefanie Remmele, Peter Börnert, Peter Mazurkewitz, Julien Senegas, Jochen Keupp, Kay Nehrke
  • Publication number: 20170116747
    Abstract: A medical imaging system (5) includes a workstation (20), a coarse segmenter (30), a fine segmenter (32), and an enclosed tissue identification module (34). The workstation (20) includes at least one input device (22) for receiving a selected location as a seed in a first contrasted tissue type and a display device (26) which displays a diagnostic image delineating a first segmented region of a first tissue type and a second segmented region of a second contrasted tissue type and identified regions which include regions fully enclosed by the first segmented region as a third tissue type. The coarse segmenter (30) grows a coarse segmented region of coarse voxels for each contrasted tissue type from the seed location based on a first growing algorithm and a growing fraction for each contrasted tissue type.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Inventors: Astrid Ruth Franz, Stefanie Remmele, Jochen Keupp
  • Patent number: 9547060
    Abstract: The invention relates to a method of MR imaging of at least a portion of a body (110) of a patient placed in an examination volume of a MR device, the method comprising the steps of:—subjecting the portion of the body (110) to an imaging sequence comprising at least one RF pulse, the RF pulse being transmitted toward the portion of the body (110) via a RF coil arrangement (109) to which RF signals are supplied by two or more RF power amplifiers the RF power amplifiers being activated alternately during the imaging sequence in a time-multiplexed fashion, wherein the imaging sequence requires a RF duty cycle and/or a RF pulse duration exceeding the specification of at least one of the RF power amplifiers;—acquiring MR signals from the portion of the body (110); and—reconstructing a MR image from the acquired MR signals. Moreover, the invention relates to a method of MR spectroscopy involving the alternating use of RF power amplifiers in a time-multiplexed fashion.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: January 17, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Jochen Keupp, Johan Samuel Van Den Brink, Paul Royston Harvey
  • Patent number: 9547061
    Abstract: A medical imaging system (5) includes a workstation (20), a coarse segmenter (30), a fine segmenter (32), and an enclosed tissue identification module (34). The workstation (20) includes at least one input device (22) for receiving a selected location as a seed in a first contrasted tissue type and a display device (26) which displays a diagnostic image delineating a first segmented region of a first tissue type and a second segmented region of a second contrasted tissue type and identified regions which include regions fully enclosed by the first segmented region as a third tissue type. The coarse segmenter (30) grows a coarse segmented region of coarse voxels for each contrasted tissue type from the seed location based on a first growing algorithm and a growing fraction for each contrasted tissue type.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: January 17, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Astrid Ruth Franz, Stefanie Remmele, Christian Stehning, Jochen Keupp