Patents by Inventor Jochen Keupp
Jochen Keupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260108166Abstract: Disclosed herein is a medical system (100, 300, 500) comprising a memory (116) storing machine executable instructions (120) and a graph database (122). The graph database is configured to output magnetic resonance imaging pulse sequence configuration data (126) in response to receiving subject data. The medical system further comprises a computational system (110). Execution of the machine executable instructions causes the computational system to: receive (200) the subject data; and receive (202) the magnetic resonance imaging pulse sequence configuration data in response to inputting the subject data into the graph database.Type: ApplicationFiled: March 29, 2024Publication date: April 23, 2026Inventors: Artur Hahn, Jan Jakob Meineke, Jochen Keupp, Peter Ulrich Boernert
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Publication number: 20260041376Abstract: Described herein is a medical system (100, 300) comprising a memory (110) storing machine executable instructions (120) and a motion estimating neural network (122, 700, 800, 900, 1000) configured for outputting trajectory data (130) in response to receiving a trial motion trajectory (128) as input. The execution of the machine executable instructions causes a computational system (104) to: receive (200) measured k-space data (124) descriptive of a subject (318); perform (202) motion estimation of the subject between the sequence of discrete acquisitions by solving an optimization problem to determine a calculated motion trajectory of the subject in the predefined coordinate system, wherein the optimization problem is modified using the trajectory data; and reconstruct (204) a final motion corrected magnetic resonance image (136) from the measured k-space data and the calculated motion trajectory in the predefined coordinate system.Type: ApplicationFiled: July 14, 2023Publication date: February 12, 2026Inventors: Karsten Sommer, Jochen Keupp, Christophe Michael Jean Schuelke, Nicola Pezzotti
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Patent number: 12535545Abstract: Disclosed herein is a mechanical gradient magnetic field generator (100, 500, 1600, 1700, 2000, 2112) comprising a field generating element (102) comprising at least one generator layer (104). Each of the at least one generator layer comprises: a stationary divider (106); a movable divider (108) configured for moving in one (110) or two (1602) displacement directions; a mechanical element (112) configured to mechanically assist movement of the movable divider in the one or two displacement directions towards an initial position (508); and a set of rotatable magnets (114) positioned between the movable divider and the stationary divider. The set of rotatable magnets are mechanically coupled to the movable divider and to the stationary divider. The mechanical coupling of the set of rotatable magnets is such that movement of the movable divider in the one or two displacement directions causes an individual rotation of each of the set of rotatable magnets.Type: GrantFiled: September 7, 2022Date of Patent: January 27, 2026Assignee: Koninklijke Philips N.V.Inventors: Bernhard Gleich, George Randall Duensing, Johannes Adrianus Overweg, Peter Ulrich Börnert, Jochen Keupp
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Patent number: 12502078Abstract: Disclosed herein is a medical system (100, 300, 700) comprising a magnetic resonance imaging system (102) configured to acquire lines of k-space (144) data from a thoracic region (122) of a subject (118). Execution of machine executable instructions (140) causes a computational system (132) to: repeatedly (200) acquire the lines of k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands; repeatedly (202) assemble motion resolved k-space data (146) from the lines of k-space data using at least one cardiac phase and one respiratory phase of the subject as the k-space data is acquired; retrieve (204) at least a portion (148) of the motion resolved k-space data during acquisition of the k-space data; and construct (206) a preliminary three-dimensional cardiac image (150) using at least a portion of the motion resolved k-space data before acquisition of the lines of k-space data is finished.Type: GrantFiled: March 11, 2022Date of Patent: December 23, 2025Assignee: Koninklijke Philips N.V.Inventors: Jochen Keupp, Jan Jakob Meineke, Christian Stehning, Christophe Michael Jean Schuelke, Mariya Invanova Doneva, Peter Ulrich Börnert
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Publication number: 20250138117Abstract: Disclosed herein is a mechanical gradient magnetic field generator (100, 500, 1600, 1700, 2000, 2112) comprising a field generating element (102) comprising at least one generator layer (104). Each of the at least one generator layer comprises: a stationary divider (106); a movable divider (108) configured for moving in one (110) or two (1602) displacement directions; a mechanical element (112) configured to mechanically assist movement of the movable divider in the one or two displacement directions towards an initial position (508); and a set of rotatable magnets (114) positioned between the movable divider and the stationary divider. The set of rotatable magnets are mechanically coupled to the movable divider and to the stationary divider. The mechanical coupling of the set of rotatable magnets is such that movement of the movable divider in the one or two displacement directions causes an individual rotation of each of the set of rotatable magnets.Type: ApplicationFiled: September 7, 2022Publication date: May 1, 2025Inventors: Bernhard Gleich, George Randall Duensing, Johannes Adrianus Overweg, Peter Ulrich Börnert, Jochen Keupp
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Patent number: 12165319Abstract: The present invention relates to an apparatus (10) for diagnostic image acquisition, comprising: an input unit (20); a processing unit (30); and an output unit (40). The input unit is configured to receive a data value relating to at least one biomarker in a measurement blood sample of a patient. The processing unit is configured to determine a time to acquire a diagnostic image of the patient, wherein the determination comprises utilization of the data value. The output unit is configured to output an indication of the time to acquire the diagnostic image of the patient.Type: GrantFiled: November 17, 2020Date of Patent: December 10, 2024Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Pieter Jan van der Zaag, Wilhelmus Franciscus Johannes Verhaegh, Jochen Keupp
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Patent number: 12019134Abstract: A method of magnet resonance (MR) imaging of an object includes MR signal acquisition in a single scan providing information for electric properties imaging (EPT), which may include a phase map as well as tissue boundaries. The method includes: subjecting the object to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence that includes RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; acquiring the echo signals; deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object; and reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image.Type: GrantFiled: June 19, 2020Date of Patent: June 25, 2024Assignee: Koninklijke Philips N.V.Inventors: Ulrich Katscher, Johan Samuel Van Den Brink, Jochen Keupp
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Publication number: 20240156346Abstract: Disclosed herein is a medical system (100, 300, 700) comprising a magnetic resonance imaging system (102) configured to acquire lines of k-space (144) data from a thoracic region (122) of a subject (118). Execution of machine executable instructions (140) causes a computational system (132) to: repeatedly (200) acquire the lines of k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands; repeatedly (202) assemble motion resolved k-space data (146) from the lines of k-space data using at least one cardiac phase and one respiratory phase of the subject as the k-space data is acquired; retrieve (204) at least a portion (148) of the motion resolved k-space data during acquisition of the k-space data; and construct (206) a preliminary three-dimensional cardiac image (150) using at least a portion of the motion resolved k-space data before acquisition of the lines of k-space data is finished.Type: ApplicationFiled: March 11, 2022Publication date: May 16, 2024Inventors: Jochen Keupp, Jan Jakob Meineke, Christian Stehning, Christophe Michael Jean Schulke, Mariya Invanova Doneva, Peter Ulrich Börnert
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Patent number: 11899083Abstract: The present invention is directed to a RF transmit system (1) for a magnetic resonance examination system where it is intended to provide a solution for the problem of rapidly switching between operation modes of different peak power requirements at good power efficiencies. For this purpose the RF transmit system (1) comprises at least one RF channel (14) wherein the RF channel (14) has an RF amplifier (3), at least two power supply devices (4, 5) wherein each of the power supply devices (4, 5) is configured to supply a voltage to the amplifier (3). The RF transmit system (1) further comprises a DC switch (8) configured to switch the voltage supplied to the amplifier (3) between the power supply devices (4, 5) and a controller (2) configured to switch the voltage based on sensor data.Type: GrantFiled: February 15, 2019Date of Patent: February 13, 2024Assignee: Koninklijke Philips N.V.Inventors: Peter Vernickel, Christoph Leussler, Ingo Schmale, Jochen Keupp
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Patent number: 11815582Abstract: A method of magnet resonance (MR) imaging of an object including: subjecting an object in an examination volume of an MR device to a dual echo steady state imaging sequence, a free induction decay signal (FID) and an echo signal (ECHO) being generated in each interval between two successive RF pulses, wherein a pair of diffusion gradient waveforms (GDIF) of equal phase integral and opposed polarity is applied in the interval between the FID signal and the echo signal; —acquiring the FID signals and the echo signals in a number of repetitions of the imaging sequence with varying phase encoding; and —reconstructing a diffusion weighted MR image from the acquired FID signals and echo signals.Type: GrantFiled: May 6, 2020Date of Patent: November 14, 2023Assignee: Koninklijke Philips N.V.Inventors: Jochen Keupp, Ulrich Wolfgang Katscher
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Publication number: 20230148892Abstract: Disclosed herein is a method of medical imaging The method comprises: receiving (200) a first electrical properties tomography conductivity map (122) for a first radio frequency value, receiving (202) a second electrical properties tomography conductivity map (124), calculating (204) a low frequency conductivity map (126) using the first electrical properties tomography conductivity map and the second electrical properties tomography conductivity map, calculating (208) an intra-cellular volume map (130) and an extra-cellular volume map (131) by performing an optimization of a two-term exponential model to the multi-b diffusion weighted magnetic resonance imaging signal spectra map, calculating (210) an intra-cellular volume fraction map (132) by performing a voxel wise division of the intra-cellular volume map by the voxel wise sum of the extra-cellular volume map plus the intra-cellular volume map, and calculating (212) an intra-cellular conductivity map (134) by performing a voxel wise division of an intermType: ApplicationFiled: March 31, 2021Publication date: May 18, 2023Inventors: Ulrich Wolfgang Katscher, Jochen Keupp
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Publication number: 20230028306Abstract: The present invention relates to an apparatus (10) for diagnostic image acquisition, comprising: an input unit (20); a processing unit (30); and an output unit (40). The input unit is configured to receive a data value relating to at least one biomarker in a measurement blood sample of a patient. The processing unit is configured to determine a time to acquire a diagnostic image of the patient, wherein the determination comprises utilization of the data value. The output unit is configured to output an indication of the time to acquire the diagnostic image of the patient.Type: ApplicationFiled: November 17, 2020Publication date: January 26, 2023Inventors: Pieter Jan van der Zaag, Wilhelmus Franciscus Johannes Verhaegh, Jochen Keupp
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Patent number: 11474182Abstract: A medical imaging system includes a memory for storing machine executable instructions. The medical imaging system further includes a processor for controlling the medical imaging system. Execution of the machine executable instructions causes the processor to: receive magnetic resonance image data acquired according to a CEST magnetic resonance imaging protocol, wherein the magnetic resonance image data includes voxels, wherein each of the voxels includes a measured Z-spectrum for a set of saturation frequency offsets; assign a motion likelihood map to each voxel by comparing the measured Z-spectrum of each voxel to predetermined criteria; and reconstruct a CEST magnetic resonance image using the magnetic resonance image data and the motion likelihood map.Type: GrantFiled: May 22, 2019Date of Patent: October 18, 2022Assignee: Koninklijke Philips N.V.Inventors: Jochen Keupp, Elwin De Weerdt
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Publication number: 20220308148Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable MR signal acquisition in a single scan providing the necessary information for electric properties imaging (EPT), namely a phase map as well as tissue boundaries. The method of the invention comprises the following steps: —subjecting the object (10) to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence comprising RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; —acquiring the echo signals; —deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object (10); and —reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image.Type: ApplicationFiled: June 19, 2020Publication date: September 29, 2022Inventors: Ulrich Katscher, Johan Samuel Van Den Brink, Jochen Keupp
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Publication number: 20220236357Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable distortion-free high-quality diffusion weighted imaging (DWI) with minimization of artefacts caused by motion. The method of the invention comprises the following steps: —subjecting the object (10) to a dual echo steady state imaging sequence, a free induction decay signal (FID) and an echo signal (ECHO) being generated in each interval between two successive RF pulses, wherein a pair of diffusion gradient waveforms (GDIF) of equal phase integral and opposed polarity is applied in the interval between the FID signal and the echo signal; —acquiring the FID signals and the echo signals in a number of repetitions of the imaging sequence with varying phase encoding; and —reconstructing a diffusion weighted MR image from the acquired FID signals and echo signals.Type: ApplicationFiled: May 6, 2020Publication date: July 28, 2022Inventors: JOCHEN KEUPP, ULRICH WOLFGANG KATSCHER
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Patent number: 11353532Abstract: The invention relates to a magnetic resonance imaging system (100) for determining an approximation (150) of an electric conductivity distribution within a three-dimensional anatomical structure of interest. The determining comprises acquiring a first set of (3-n)-dimensional magnetic resonance data (144), reconstructing a (3-n)-dimensional phase distribution (146) using the (3-n)-dimensional magnetic resonance data (144), calculating a (3-n)-dimensional electric conductivity distribution (148) using spatial derivatives within the (3-n) dimensions and applying to the (3-n)-dimensional electric conductivity distribution (148) a scaling factor compensating for the relative reduction of dimensions by n.Type: GrantFiled: March 11, 2019Date of Patent: June 7, 2022Assignee: Koninklijke Philips N.V.Inventors: Ulrich Katscher, Christian Findelkee, Jochen Keupp
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Patent number: 11327136Abstract: The invention provides for a medical imaging system (100, 300). The medical imaging system comprises a processor (104).Type: GrantFiled: January 7, 2019Date of Patent: May 10, 2022Assignee: Koninklijke Philips N.V.Inventors: Jochen Keupp, Holger Eggers
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Patent number: 11320508Abstract: The invention relates to a magnetic resonance imaging data processing system (126) for processing motion artifacts in magnetic resonance imaging data sets using a deep learning network (146, 502, 702) trained for the processing of motion artifacts in magnetic resonance imaging data sets. The magnetic resonance imaging data processing system (126) comprises a memory (134, 136) storing machine executable instructions (161, 164) and the trained deep learning network (146, 502, 702). Furthermore, the magnetic resonance imaging data processing system (126) comprises a processor (130) for controlling the magnetic resonance imaging data processing system.Type: GrantFiled: October 22, 2018Date of Patent: May 3, 2022Assignee: Koninklijke Philips N.V.Inventors: Karsten Sommer, Tom Brosch, Tim Philipp Harder, Jochen Keupp, Ingmar Graesslin, Rafael Wiemker, Axel Saalbach
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Patent number: 11307277Abstract: A medical analysis system (111) for processing magnetic resonance imaging (MRI), data (170) from a target volume (208) in a subject (218) includes a memory (107) for storing machine executable instructions; and a processor (103) for controlling the system (111). Execution of the machine executable instructions causes the processor (103) to: determine from the MRI data (103) chemical exchange saturation transfer (CEST) voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weight the CEST values in order to distinguish CEST values of fluid-rich tissues (507) from CEST values of solid tissues (505) in the target volume (208), wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid.Type: GrantFiled: January 2, 2019Date of Patent: April 19, 2022Assignee: Koninklijke Philips N.V.Inventor: Jochen Keupp
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Publication number: 20210215782Abstract: The invention provides for a medical imaging system (100, 300) comprising a memory (110) for storing machine executable instructions (120). The medical imaging system further comprises a processor (104) for controlling the medical imaging system. Execution of the machine executable instructions causes the processor to: receive (200) magnetic resonance image data (122) acquired according to a CEST magnetic resonance imaging protocol, wherein the magnetic resonance image data comprises voxels, wherein each of the voxels comprises a measured Z-spectrum (500) for a set of saturation frequency offsets (502, 504, 504?, 506, 506?, 508, 510); assign (202) a motion likelihood map (126) to each voxel by comparing the measured Z-spectrum of each voxel to predetermined criteria; and reconstruct (204) a CEST magnetic resonance image (128) using the magnetic resonance image data and the motion likelihood map.Type: ApplicationFiled: May 22, 2019Publication date: July 15, 2021Inventors: JOCHEN KEUPP, ELWIN DE WEERDT