Abstract: The present invention relates to a method for the simultaneous amplification of a plurality of different nucleic acid target sequences comprising the steps of providing a plurality of different nucleic acid polymers as templates, each template comprising a specific target sequence and a primer annealing sequence located downstream of the target sequence, and amplifying the template by a polymerase dependent amplification reaction using a primer oligonucleotide comprising a primer sequence which is at least essentially complementary to the primer annealing sequence. The method is characterized in that for the polymerase dependent amplification reaction a set of primer oligonucleotides is used, said set comprising at least two primer oligonucleotides which are able to anneal to the primer annealing sequence of the same template and which differ from each other in the efficiency for the polymerase dependent amplification reaction to take place.

Abstract: There is described a novel class of calcium binding proteins of the nervous system, in particular calsyntenin-1-3. Calsyntenin proteins are valuable agents in the treatment of disorders of the nervous system, in particular the central nervous system. They are very useful for the development of drugs for the treatment of disorders of the nervous system.