Abstract: Disclosed are ion-sensitive polymers and methods for their use for monitoring biological phenomena associated with ion fluxes, as well as organic electrochemical transistors including such polymers.

Abstract: A gas analyzer via which exhaust gas to be analyzed is conducted untreated through a first measurement chamber and, after treatment in an oxidation device, through a second measurement chamber, wherein ozone is produced from oxygen to thereby convert nitrogen monoxide into nitrogen dioxide, where the gas analyzer has a first light emitting diode and a second light emitting diode, light of both diodes is conducted through the first measurement chamber onto a first detector, light of the first light emitting diode is partly conducted through the second measurement chamber onto a second detector via a beam splitter arrangement, based on the first detector signal, the nitrogen dioxide concentration of the untreated gas is also measured, based on the second detector signal, the nitrogen dioxide concentration of the treated exhaust gas is measured, and the nitrogen oxide concentration of the exhaust gas is additionally determined from measured nitrogen dioxide concentrations.

Abstract: A gas analyzer via which exhaust gas to be analyzed is conducted untreated through a first measurement chamber and, after treatment in an oxidation device, through a second measurement chamber, wherein ozone is produced from oxygen to thereby convert nitrogen monoxide into nitrogen dioxide, where the gas analyzer has a first light emitting diode and a second light emitting diode, light of both diodes is conducted through the first measurement chamber onto a first detector, light of the first light emitting diode is partly conducted through the second measurement chamber onto a second detector via a beam splitter arrangement, based on the first detector signal, the nitrogen dioxide concentration of the untreated gas is also measured, based on the second detector signal, the nitrogen dioxide concentration of the treated exhaust gas is measured, and the nitrogen oxide concentration of the exhaust gas is additionally determined from measured nitrogen dioxide concentrations.

Abstract: The invention relates to a belt retractor for a safety belt, having: a belt reel (100, 200, 300, 400, 500, 600) for winding up the safety belt; a locking base (120, 220, 320, 420, 520, 620) which during normal operation is conjointly rotated with the belt reel and the rotary motion of which upon abrupt belt extraction is locked by means of a locking mechanism; and a belt force limiting installation which upon locking of the locking base permits relative rotation between the belt reel and the locking base. It is provided according to the invention that the belt retractor has a deactivation installation which after a predefined maximum relative rotary angle between the locking base and the belt reel blocks the relative rotation which is permitted between the belt reel and the locking base by the belt force limiting installation and, on account thereof, deactivates the belt force limiting installation.

Abstract: The invention relates to a sensor (2) including: a microelectrode assembly (21); and ?-pancreatic cells (23) or islets (230) of Langerhans in culture on the microelectrode assembly (21); characterized in that the microelectrode assembly (21) is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the ?-pancreatic cells (23) or the islets of Langerhans (230) upon physiological activation. The invention also relates to the field of devices that can be implantable in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.

Abstract: The invention relates to a belt retractor for a safety belt, having: a belt reel (100, 200, 300, 400, 500, 600) for winding up the safety belt; a locking base (120, 220, 320, 420, 520, 620) which during normal operation is conjointly rotated with the belt reel and the rotary motion of which upon abrupt belt extraction is locked by means of a locking mechanism; and a belt force limiting installation which upon locking of the locking base permits relative rotation between the belt reel and the locking base. It is provided according to the invention that the belt retractor has a deactivation installation which after a predefined maximum relative rotary angle between the locking base and the belt reel blocks the relative rotation which is permitted between the belt reel and the locking base by the belt force limiting installation and, on account thereof, deactivates the belt force limiting installation.

Abstract: The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I. In the process, an isothiocyanate of formula II is initially reacted with a primary amine or formula III to give a thiourea of formula IV. Subsequently, the thiourea of formula IV is converted to the corresponding heterocycle of formula I using a base and a sulfonyl chloride.

Abstract: An occupant protection device including a pyrotechnical gas generator and a safety valve operating in a temperature-dependent manner and leading to the outside is connected to the gas generator. A sealing element of the safety valve is formed by a pin that includes a pin head, which is inserted from inside into a hole in a wall of a supply element such that the pin head bears against the inner face of the wall. A pin end, which is located on the outer face of the wall and protrudes outwardly through the hole, is plastically reshaped, so that the cross section of the pin end is larger than the cross section of the hole thereby forming a sealing portion which is larger in cross section than the cross section of the hole.

Abstract: The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds and pharmaceutical compositions comprising them which are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE-3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke. More specifically, the present invention relates to substituted 4-phenyl-tetrahydroisoquinolines defined by the formula I in which R1-R8 are defined herein.

Abstract: The invention relates to a sensor (2) including: a microelectrode assembly (21); and ?-pancreatic cells (23) or islets (230) of Langerhans in culture on the microelectrode assembly (21); characterized in that the microelectrode assembly (21) is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the ?-pancreatic cells (23) or the islets of Langerhans (230) upon physiological activation. The invention also relates to the field of devices that can be implantable in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.

Abstract: The invention relates, amongst other things, to an occupant protection device comprising a pyrotechnical gas generator (40). According to the invention it is provided that a safety valve (200) operating in a temperature-dependent manner and leading to the outside is connected to the gas generator.

Abstract: The present invention relates to compounds useful in the prevention or treatment of various disorders such as acute or chronic renal failure, for impairments of biliary function, for respiratory impairments such as snoring or sleep apneas or for stroke, and pharmaceutical compositions comprising them. More specifically, the compounds of the present invention comprises substituted 1-amino-4-phenyl-dihydroisoquinolines and their derivatives of formula I: Wherein the substituents R1-R11 are more specifically defined hereinbelow. The claimed compounds of the present invention also include their pharmaceutically acceptable salts and trifluoroacetates thereof as well as methods for their preparation and pharmaceutical delivery systems thereof.

Abstract: The invention relates to NHE-3 inhibitor compounds of formula I: In which R1-R11 are more specifically defined herein. These substituted 2-amino-4-phenyl-dihydroquinolines are useful the treatment of various renal and respiratory disorders such as acute or chronic renal failure, for impairments of biliary function and respiratory impairments such as snoring, sleep apneas or stroke. Formulations comprising them and methods for their use are also described herein.

Abstract: This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.

Abstract: A seat belt retractor for a safety belt including a seat belt spindle for winding up and unwinding the safety belt and a tensioning drive. The seat belt spindle includes a gas generator, a drive wheel and a supply pipe which connects the gas generator and the drive wheel. A plurality of thrust members are present in the supply pipe which, after triggering the gas generator, are accelerated and indirectly or directly drive the drive wheel for winding up the safety belt. An inertia coupling is arranged between the drive wheel and the seat belt spindle. The inertia coupling comprises coupling elements which, during an acceleration of the drive wheel, pivot outward and are directly or indirectly coupled to the seat belt spindle.

Abstract: The invention is concerned, inter alia, with a belt retractor (10) for a seat belt, with a belt reel (20) for winding up and unwinding the seat belt, and a lockable locking flange (40) which is connected to the belt reel and, prior to a locking action, is rotated together with the belt reel and, after a locking action, is blocked in its rotational movement. According to the invention, it is provided that the locking flange and the belt reel are secured against relative axial displacement.

Abstract: The invention relates to substituted 4-phenyltetrahydroisoquinolines of formula I wherein R1-R8, N, W, X and Z are defined herein. These compounds and pharmaceutical compositions comprising them are useful in the treatment of respiratory disorders, sleep apnea, kidney disorders, high blood pressure, hypertension, disorders of the central nervous system and the like.

Abstract: The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds of the structure of formula I and pharmaceutical compositions comprising them wherein the R groups are herein defined. These are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke.

Abstract: The present invention comprises compounds and compositions comprising substituted thiophene derivatives with the following backbone structure: The compounds of this type are of useful in the treatment of various disorders, such as, respiratory disorders and snoring, acute and chronic disorders, disorders induced by ischemic and/or reperfusion events and by proliferative or fibrotic events, disorders of the central nervous system and lipid metabolism, diabetes, blood coagulation and infection by parasites.

Abstract: A seat belt retractor for a safety belt including a seat belt spindle for winding up and unwinding the safety belt and a tensioning drive. The seat belt spindle includes a gas generator, a drive wheel and a supply pipe which connects the gas generator and the drive wheel. A plurality of thrust members are present in the supply pipe which, after triggering the gas generator, are accelerated and indirectly or directly drive the drive wheel for winding up the safety belt. An inertia coupling is arranged between the drive wheel and the seat belt spindle. The inertia coupling comprises coupling elements which, during an acceleration of the drive wheel, pivot outward and are directly or indirectly coupled to the seat belt spindle.