Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

Abstract: Provided are personal care compositions comprising a polyacrylate oil gel composition comprising (a) hydrophobic ester oil, and (b) one or more polymers comprising polymerized units derived from (i) 85 to 100 weight % of C4-C8 (meth)acrylate monomers, and (ii) 0 to 15 weight % of high Tg monoethylenically unsaturated monomers having a Tg of more than 90° C. after polymer formation.

Abstract: A method of making a hair care composition is provided, comprising: providing a cationic hair care emulsion, comprising: a cationic surfactant; optionally, a nonionic surfactant; water, wherein the water forms a continuous phase; and an internal phase, wherein the internal phase comprises: a cosmetically acceptable hydrocarbon oil; and a polyolefin blend, comprising: a high density polyolefin having a density of >0.90 g/cm3; and a low density polyolefin having a density of ?0.90 g/cm3; wherein the polyolefin blend has an average melt index of >7 as measured according to ASTM D 1238; providing a cosmetically acceptable silicone; providing an additional water; providing at least one hair care additive; and combining the cationic hair care emulsion, the cosmetically acceptable silicone, the additional water and the at least one hair care additive to form the hair care composition.

Abstract: Provided is a concentrated emulsion and personal care compositions containing the concentrated emulsion. The emulsion comprises: (a) from 60 to 95 wt %, based on the total weight of the emulsion, of an internal phase comprising: (i) a low density polyolefin with a density equal to or below 0.90 g/cm3, and (ii) a cosmetically acceptable solvent; (b) from 0.1 to 30 wt %, based on the total weight of the emulsion, of a surfactant; and (c) balance water as a continuous phase.

Abstract: A method of making a hair care composition is provided, comprising: providing a cationic hair care emulsion, comprising: a cationic surfactant; optionally, a nonionic surfactant; water, wherein the water forms a continuous phase; and an internal phase, wherein the internal phase comprises: a cosmetically acceptable hydrocarbon oil; and a polyolefin blend, comprising: a high density polyolefin having a density of >0.90 g/cm3; and a low density polyolefin having a density of ?0.90 g/cm3; wherein the polyolefin blend has an average melt index of >7 as measured according to ASTM D 1238; providing a cosmetically acceptable silicone; providing an additional water; providing at least one hair care additive; and combining the cationic hair care emulsion, the cosmetically acceptable silicone, the additional water and the at least one hair care additive to form the hair care composition.

Abstract: A cationic hair care emulsion is providing including: a cationic surfactant; water, wherein the water forms a continuous phase; and an internal phase, wherein the internal phase comprises: a cosmetically acceptable hydrocarbon oil; and a polyolefin blend, comprising: a high density polyolefin having a density >0.90 g/cm3; and a low density polyolefin having a density of ?0.90 g/cm3; wherein the polyolefin blend has an average melt index of >7 as measured according to ASTM D 1238.

Abstract: A cationic hair care emulsion is providing including: a cationic surfactant; water, wherein the water forms a continuous phase; and an internal phase, wherein the internal phase comprises: a cosmetically acceptable hydrocarbon oil; and a polyolefin blend, comprising: a high density polyolefin having a density >0.90 g/cm3; and a low density polyolefin having a density of ?0.90 g/cm3; wherein the polyolefin blend has an average melt index of >7 as measured according to ASTM D 1238.

Abstract: Provided is a concentrated emulsion and personal care compositions containing the concentrated emulsion. The emulsion comprises: (a) from 60 to 95 wt %, based on the total weight of the emulsion, of an internal phase comprising: (i) a low density polyolefin with a density equal to or below 0.90 g/cm3, and (ii) a cosmetically acceptable solvent; (b) from 0.1 to 30 wt %, based on the total weight of the emulsion, of a surfactant; and (c) balance water as a continuous phase.

Abstract: Provided is a concentrated emulsion and hair care compositions containing the concentrated emulsion. The emulsion comprises (a) an internal phase containing (i) a high density polyolefin with a density above 0.90 g/cm3, (ii) a low density polyolefin with a density equal to or below 0.90 g/cm3, and (iii) a cosmetically acceptable hydrocarbon oil; (b) from 0.1 to 15 wt %, based on the total weight of the emulsion, of a surfactant; and (c) balance water as a continuous phase, wherein the high and low density polyolefins have an average melt index greater than 7.

Abstract: A composition comprising a gelling agent is provided. The gelling agent consists essentially of a cellulose ether based gelling polymer and the composition is a rigid foam at 20 degrees Celsius. The composition may also comprise an active ingredient. Also provided is a process of making the composition comprising drying a foamed liquid composition comprising the gelling agent at low temperatures. The foamed liquid composition may also comprise an active ingredient.