Abstract: A knife gate valve comprising a two-piece valve body, a knife gate, an elastomeric transverse seal, an elastomeric perimeter seal, and a pair of elastomer liners. Each elastomer liner is positioned between the knife gate and one of the mating valve body halves and defines a chamber for receiving the perimeter seal. Each liner has a port that corresponds to the flow channel, a sealing portion that extends into a sealing chamber to cooperate with the transverse seal, and an orifice liner extension that lines the orifice of the corresponding valve body half. O-rings, preferably of a softer material than the elastomer liner, may be positioned on the outer rim of the orifice liner extensions for creating a seal among the elastomer liner, the corresponding valve body half, and a corresponding mating flange of a fluid handling system.