Patents by Inventor Joe Adam WAHLE

Joe Adam WAHLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDES FOR SPLICE MODULATION OF CARD9
    Publication number: 20230193269
    Abstract: The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD.
    Type: Application
    Filed: May 22, 2020
    Publication date: June 22, 2023
    Inventors: Peter HAGEDORN, Lars JOENSON, Anja Moehart HOEG, Jonas VIKESSA, Fergus BYRNE, Jay FINE, Mouhamadou MBOW, Joe Adam WAHLE, Elliott Sanford KLEIN, Kristina Mary SAI, Fei SHEN
  • ANTISENSE OLIGONUCLEOTIDES TARGETING CARD9
    Publication number: 20220042011
    Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory bowel disease, pancreatitis, IgA nephropathy, primary sclerosing cholangitis, cardiovascular disease, cancer and diabetes.
    Type: Application
    Filed: December 20, 2019
    Publication date: February 10, 2022
    Applicants: Hoffmann-La Roche Inc., Boehringer Ingelheim International GmbH
    Inventors: Jay FINE, Mouhamadou Lamine MBOW, Joe Adam WAHLE, Fei SHEN, Elliott Sanford KLEIN, Kristina Mary SAI, Peter HAGEDORN, Anja MOELHART HOEG