Patents by Inventor Joe B. Harford

Joe B. Harford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR REDUCING SIDE EFFECTS OF IMMUNOTHERAPY
    Publication number: 20200113829
    Abstract: This invention provides methods to overcome the current limitations of immune checkpoint immunotherapy to provide more effective methods of treating cancer. In embodiments this invention provides a means of using of p53 gene therapy to augment immune checkpoint inhibition by combining antibodies targeting immune checkpoint molecules with SGT-53, a nanomedicine carrying a plasmid encoding human wild-type p53. This invention provides means of increasing tumor immunogenicity, enhancing both innate and adaptive immune responses, and reducing tumor-induced immunosuppression, sensitizing otherwise refractory tumors to anti-immune checkpoint antibodies. In other embodiments this invention also unexpectedly reduces immune-related toxicities that are seen with immunotherapies.
    Type: Application
    Filed: October 10, 2019
    Publication date: April 16, 2020
    Inventors: Esther H. Chang, Joe B. Harford, Sang Soo Kim
  • Methods for treating hormone disorders
    Patent number: 6410715
    Abstract: Method for screening for a non-hormone agent potentially useful to treat a hormone disorder The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: June 25, 2002
    Assignees: Questcor Pharmaceuticals, Inc., Mc Gill University
    Inventors: Nahum Sonenberg, Arnim Pause, Joe B. Harford, Vincent J. Miles
  • Methods for treating hormone disorders
    Patent number: 6111077
    Abstract: Method for screening for a non-hormone agent potentially useful to treat a hormone disorder The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: August 29, 2000
    Assignees: RiboGene, Inc., McGill University
    Inventors: Nahum Sonenberg, Arnim Pause, Joe B. Harford, Vincent J. Miles
  • Methods of screening for non-hormone compounds which effect modulation of polypeptide translation
    Patent number: 5874231
    Abstract: Method for screening for a non-hormone agent potentially useful to treat a hormone disorder. The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: February 23, 1999
    Assignees: McGill University, Ribogene, Inc.
    Inventors: Nahum Sonenberg, Arnim Pause, Joe B. Harford, Vincent J. Miles