Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.

Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.

Abstract: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

Abstract: There is provided an HSV Complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

Abstract: Herpes Simplex Viruses are disclosed having single-chain antibodies (scFv) embedded in the viral envelope via fusion with glycoprotein D and with glycoprotein H and L.

Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.

Abstract: A method of generating a mutant Herpes Simplex Virus (HSV) is disclosed, wherein the generated HSV genome comprises nucleic acid encoding a nucleic acid sequence of interest, the method comprising the steps of: i. providing a nucleic acid vector comprising nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences; ii. providing an HSV, the genome of which comprises third and fourth site specific recombination sequences; iii. contacting said nucleic acid vector of (i) with said HSV of (ii) together with one or more recombinase enzymes capable of catalysing site specific recombination between the site specific recombination sequences of said nucleic acid vector and said HSV; iv. identifying HSV containing the nucleic acid sequence of interest, wherein steps i-iii are conducted in a cell-free system.

Abstract: The present invention relates to construct and methods which allow the expression of immunoglobulins or functional fragments thereof which have been altered to that they are humanised. The expression of the immunoglobulins or fragments thereof takes place in avian cells, and the constructs used have been altered such that the expression levels in avian cells are higher than what would have been expected by simply using a humanised construct. The alterations are based on changing codons so that each amino acid of the codon that is used is the one which is most often found in avians.

Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding insulin is disclosed. Viruses disclosed are capable of expressing insulin. They may lack neurovirulence and may find use in the treatment of diseases involving abnormal insulin expression or function, such as diabetes.

Abstract: A nucleic acid vector comprising first and second nucleotide sequences corresponding to nucleotide sequences flanking an insertion site in the genome of a selected herpes simplex virus strain; and a cassette located between said first and second nucleotide sequences comprising nucleic acid encoding: (a) one or a plurality of insertion sites and/or a nucleotide sequence of interest; and (b) a ribosome binding site or a regulatory nucleotide sequence; and (c) a marker is disclosed. Herpes simplex viruses generated using said vector, methods for their generation and herpes simplex viruses having a genome comprising heterologous nucleic acid are also disclosed.

Abstract: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

Abstract: A method of sorting a received information message in which a source of delivery of the message is indicated by a unique identifier accompanying the message, for example, in an e-mail or voice message system. The method includes steps of receiving the message, looking-up the identifier in a database, assigning a code for the message per the result of the step of looking-up, and prioritizing or forwarding the message according to the code.

Abstract: A method of sorting a received information message in which a source of delivery of the message is indicated by a unique identifier accompanying the message, for example, in an e-mail or voice message system. The method includes steps of receiving the message, looking-up the identifier in a database, assigning a code for the message per the result of the step of looking-up, and prioritizing or forwarding the message according to the code.

Abstract: A method of sorting a received information message in which a source of delivery of the message is indicated by a unique identifier accompanying the message, for example, in an e-mail or voice message system. The method includes steps of receiving the message, looking-up the identifier in a database, assigning a code for the message per the result of the step of looking-up, and prioritizing or forwarding the message according to the code.

Abstract: A method of sorting a received information message in which a source of delivery of the message is indicated by a unique identifier accompanying the message, for example, in an e-mail or voice message system. The method includes steps of receiving the message, looking-up the identifier in a database, assigning a code for the message per the result of the step of looking-up, and prioritizing or forwarding the message according to the code.