Patents by Inventor Joe Gray
Joe Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7785813Abstract: This invention provides methods employing prefoldin-4 (PFDN-4) nucleic acid and polypeptide sequences to detect cancer or a propensity to develop cancer, to monitor the efficacy of a cancer treatment, and/or for prognostic applications. Further, the invention provides methods of identifying inhibitors of PfDN-4 and methods of treating cancer by inhibiting the expression and/or activity of PFDN-4.Type: GrantFiled: June 19, 2006Date of Patent: August 31, 2010Assignee: Regents of the University of CaliforniaInventors: Joe Gray, Graeme Hodgson, Douglas Hanahan, Jeffrey Hager, Oriol Casanovas
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Publication number: 20070172883Abstract: The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.Type: ApplicationFiled: March 29, 2007Publication date: July 26, 2007Inventors: Daniel Pinkel, Donna Albertson, Joe Gray
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Publication number: 20070037202Abstract: This invention provides methods, reagents and kits for treating cancer in a patient or subject, e.g., a human. Accordingly, the present methods can be used to monitor the efficacy of a cancer treatment and to treat cancer, e.g., by inhibiting the expression and/or activity of ZNF217 in a neoplastic cell.Type: ApplicationFiled: October 18, 2006Publication date: February 15, 2007Applicant: Regents of the University of CaliforniaInventors: Colin Collins, Guiqing Huang, Joe Gray
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Publication number: 20070015724Abstract: This invention provides methods employing prefoldin-4 (PFDN-4) nucleic acid and polypeptide sequences to detect cancer or a propensity to develop cancer, to monitor the efficacy of a cancer treatment, and/or for prognostic applications. Further, the invention provides methods of identifying inhibitors of PfDN-4 and methods of treating cancer by inhibiting the expression and/or activity of PFDN-4.Type: ApplicationFiled: June 19, 2006Publication date: January 18, 2007Applicant: The Regents of the University of CaliforniaInventors: Joe Gray, Graeme Hodgson, Douglas Hanahan, Jeffrey Hager, Oriol Casanovas
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Publication number: 20060292608Abstract: Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and/or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread.Type: ApplicationFiled: May 8, 2006Publication date: December 28, 2006Inventors: Daniel Pinkel, Joe Gray, Anne Kallioniemi, Olli-Pekka Kallioniemi, Frederic Waldman
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Publication number: 20060292591Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: February 6, 2006Publication date: December 28, 2006Inventors: Joe Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20060257895Abstract: Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and/or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread.Type: ApplicationFiled: February 24, 2006Publication date: November 16, 2006Applicant: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Joe Gray, Anne Kallioniemi, Ollie-Pekka Kallioniemi, Frederic Waldman, Masaru Sakamoto
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Publication number: 20060160162Abstract: The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention.Type: ApplicationFiled: December 1, 2005Publication date: July 20, 2006Inventors: Mack Fulwyler, Joe Gray
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Publication number: 20060063168Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).Type: ApplicationFiled: February 16, 2005Publication date: March 23, 2006Inventors: Donna Albertson, Daniel Pinkel, Jane Fridyland, Bing Huey, Antoine Snijders, Joe Gray, Anne Kallioniemi, Olli-Pekka Kallioniemi, Frederic Waldman
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Publication number: 20050137389Abstract: The invention relates generally to the field of cytogenetics, and more particularly to methods for identifying and classifying chromosomes.Type: ApplicationFiled: September 1, 2004Publication date: June 23, 2005Applicant: The Regents of the University of CaliforniaInventors: Joe Gray, Daniel Pinkel
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Publication number: 20050118634Abstract: Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and/or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread.Type: ApplicationFiled: December 17, 2004Publication date: June 2, 2005Applicant: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Joe Gray, Anne Kallioniemi, Olli-Pekka Kallioniemi, Frederic Waldman
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Publication number: 20050084898Abstract: The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.Type: ApplicationFiled: December 3, 2004Publication date: April 21, 2005Applicants: The Regents of the University of California, Medical Research CouncilInventors: Daniel Pinkel, Donna Albertson, Joe Gray
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Publication number: 20050048561Abstract: The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention.Type: ApplicationFiled: October 6, 2004Publication date: March 3, 2005Applicant: The Regents of the University of CaliforniaInventors: Mack Fulwyler, Joe Gray
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Publication number: 20050009033Abstract: This invention is based upon the discovery that EPHA2, BAG4, and ARF1 are amplified and overexpressed in cancer. The present invention therefore provides methods, reagents, and kits for diagnosing and treating breast cancer.Type: ApplicationFiled: July 8, 2003Publication date: January 13, 2005Applicant: The Regents of the University of CaliforniaInventors: Joe Gray, Richard Neve, Frank McCormick, Jennifer Yeh, Koei Chin, Madhu Macrae
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Publication number: 20040053866Abstract: The present invention provides methods of detecting cancer cells in a patient. The methods comprise detecting SXR function in a biological sample from the patient.Type: ApplicationFiled: August 21, 2002Publication date: March 18, 2004Applicant: The Regents of the University of CaliforniaInventors: Jeff Hager, Graeme Hodgson, Douglas Hanahan, Joe Gray
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Patent number: 6465182Abstract: The present invention provides methods of determining relative copy number of target nucleic acid sequences and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acid sequences immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acid sequences are hybridized. The hybridization of the labeled nucleic acid sequences to the solid surface is then detected using standard techniques.Type: GrantFiled: April 29, 1999Date of Patent: October 15, 2002Assignee: The Regents of the University of CaliforniaInventors: Joe Gray, Dan Pinkel, Donna Albertson, Colin Collins, Russell Baldocchi
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Publication number: 20020137090Abstract: The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its “sensor end” biological “binding partners” (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles.Type: ApplicationFiled: May 21, 2002Publication date: September 26, 2002Applicant: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Joe Gray, Donna Albertson
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Patent number: 6417506Abstract: The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its “sensor end” biological “binding partners” (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles.Type: GrantFiled: August 17, 2000Date of Patent: July 9, 2002Assignees: The Regents of the University of California, Medical Research CouncilInventors: Daniel Pinkel, Joe Gray, Donna G. Albertson
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Patent number: 6146593Abstract: The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles.Type: GrantFiled: July 24, 1997Date of Patent: November 14, 2000Assignees: The Regents of the University of California, Medical Research CouncilInventors: Daniel Pinkel, Joe Gray, Donna G. Albertson
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Patent number: 5892010Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: July 15, 1996Date of Patent: April 6, 1999Assignees: The Regents of the University of California, The Hospital for Sick ChildrenInventors: Joe Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens