Abstract: Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.

Abstract: An electrical apparatus that includes a cable connected to a transmission optimizer and configured to conduct a current for matching a desired power output. The cable includes at least one insulated conductor core including an innermost insulating layer disposed around the outside of a conducting layer having carbon fiber or graphite fiber as a conductor core. The cable is a single core cable having a single insulated conductor core or a multi-core cable having multiple single insulated conductor cores.

Abstract: Electrical Apparatus (100) includes an end of a cable (500) being connected to a transmission optimizer (20), and the cable (500) conducts a current in the range of 0.01 mA to 800 A at a voltage ranges from 12V to 140 KV for the transmission of power, data and signal. The cable (500) includes at least one insulated conductor core formed with an innermost insulating layer (220) disposing around the outside of a conducting layer (210) having carbon fibre or graphite fibre as a conductor core (210). The cable (500) includes a single insulated conductor core to form a single-core cable (300). A reinforcement layer (250) and or a shielding layer (230), (232) being provided around the outside of the innermost insulating layer (220). An outer insulating layer (240) disposes around the outside of the reinforcement layer (250) and the shielding layer. The cable (500) includes multiple numbers of single insulated conductor core to form a multi-core cable (400).

Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.

Abstract: Ignition apparatus includes high tension ignition cable. The cable is of low electrical resistance per unit length. A central core of the cable is formed of carbon fibre filaments. An insulating layer is provided around the core. A semiconductor layer is provided around the insulating layer. Another insulating layer is provided around the semiconductor layer. A layer of yarn around the other insulating layer forms a protecting layer. A protective layer of a flame retardant material forms an outer layer of the cable. The ignition apparatus also includes one or more of: a field stabilizer device for stabilizing and regulating high tension voltage in the cable; resistor spark plugs; connectors fitted to ends of the cable that include resistors therein, such as resistor spark plug boots.

Abstract: Ignition apparatus includes high tension ignition cable. The cable is of low electrical resistance per unit length. A central core of the cable is formed of carbon fibre filaments. An insulating layer is provided around the core. A semiconductor layer is provided around the insulating layer. Another insulating layer is provided around the semiconductor layer. A layer of yarn around the other insulating layer forms a protecting layer. A protective layer of a flame retardant material forms an outer layer of the cable. The ignition apparatus also includes one or more of: a field stabilizer device for stabilizing and regulating high tension voltage in the cable; resistor spark plugs; connectors fitted to ends of the cable that include resistors therein, such as resistor spark plug boots.

Abstract: Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3? hydroxyl group. Methods of sequencing DNA using the substrates are also described.

Abstract: Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.

Abstract: Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

Abstract: Compositions, methods and kits for labeling proteins and uses in reporter systems for detecting, quantifying and/or characterizing analytes.

Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.

Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.

Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.