Abstract: Catheter systems of the invention involve guided and informed dissolution of occlusions in blood vessels. According to certain aspects, a catheter system of the invention includes an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site, and an imaging assembly located at the distal portion of the elongate body. In some embodiments, the catheter system includes a functional flow sensor in addition to or as an alternative to the imaging assembly.

Abstract: Catheter systems of the invention are directed to the removal of occlusions, such as thrombi and plaque, within blood vessels. In certain aspects, catheter systems of the invention include an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site; and a dissolution element coupled to the distal portion of the elongate body. The dissolution element may include a heating element, steam, and a balloon.

Abstract: Catheter systems of the invention involve guided and informed dissolution of occlusions in blood vessels. According to certain aspects, a catheter system of the invention includes an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site, and an imaging assembly located at the distal portion of the elongate body. In some embodiments, the catheter system includes a functional flow sensor in addition to or as an alternative to the imaging assembly.

Abstract: Catheter systems of the invention are directed to the removal of occlusions, such as thrombi and plaque, within blood vessels. In certain aspects, catheter systems of the invention include an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site; and a dissolution element coupled to the distal portion of the elongate body. The dissolution element may include a heating element, steam, and a balloon.

Abstract: The invention generally relates to devices and methods for imaging and delivery thrombolytic agents to biological material inside a vessel. In certain embodiments, the invention provides devices that include a body configured to fit within a lumen of a vessel. The body includes an opening. Devices of the invention also include a channel within the body. The channel includes a distal end that is connected to the opening. Devices of the invention also include an imaging assembly coupled to the body.