Abstract: Described are ion implantation devices, systems, and methods, and in particular to an ion source that is useful for generating an aluminum ion beam.

Abstract: Disclosed are Variable Displacement Power Controllers and applications generally in the field of fluid powered systems that provide for increased efficiency and effectiveness over known fluid systems, where fluid power generally refers to hydraulic or pneumatic power systems.

Abstract: The present invention relates to bicyclic heteroaromatic urea or carbamate compounds of formula I where the variables are as defined in the claims and the description. The invention moreover relates to a pharmaceutical composition containing these compounds I, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization.

Abstract: The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.

Abstract: The present invention relates to compounds of the formula I as described below or a tautomer or a pharmaceutically acceptable salt thereof; to a pharmaceutical composition containing such compounds; and to said compounds of the formula I or a tautomer or a pharmaceutically acceptable salt thereof for use as a medicament, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization, wherein X1 is CR1 or N; X2 is CR2 or N; X3 is CR3 or N; X4 is CR4 or N; Y1 is N, NR5a, S, O or CR5b; Y2 is N, NR5c, S, O or CR5d; Z is N or C; with the proviso that at most two of X1, X2, X3 and X4 are N; with the proviso that Y1 is not O if Y2 is CR5d and simultaneously Z is C; with the proviso that Y1 and Y2 are not both simultaneously O or S; with the proviso that at least one of Y1, Y2 and Z is a heteroatom or heteroatom-contai

Abstract: The present invention relates to benzofuran ureas or carbamates of formula I and heteroaromatic analogues thereof as described below or a tautomer or a pharmaceutically acceptable salt thereof; to a pharmaceutical composition containing these compounds, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization. Formula (I) wherein X1 is CR1 or N; X2 is CR2 or N; X3 is CR3 or N; X4 is CR4 or N; with the proviso that at most two of X1, X2, X3 and X4 are N; E1 is O or NR6a; E2 is O or NR6b; with the proviso that E and E2 are not simultaneously O; L1 is a bond, optionally substituted C1-C6-alkylene or C3-C8-cycloalkylene; L2 is a bond, optionally substituted C1-C6-alkylene, C3-C8-cycloalkylene, etc.

Abstract: The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.

Abstract: An external seatbelt indicator provides a red indicator light that appears on the front and rear of the vehicle when the driver's seat is occupied, the vehicle's ignition switch is in the on position, the vehicle is in any forward or reverse gear, and the driver's seatbelt is unfastened. The red indicator light may include, but is not limited to a written message, such as, “No Seat Belt,” or it may be in another form, such as a silhouette of a seated person wearing a seatbelt and shoulder harness.

Abstract: The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).

Abstract: The present invention provides compounds of formula (I), wherein R1 is a monocyclic 5- or 6-membered heteroaryl; R4 is phenyl or monocyclic 5- or 6-membered heteroaryl; and the other substituents as defined in the claims, that inhibit cell and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)—mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders.

Abstract: An automatic animal feeder, comprises a barrel, spinner plate, and control unit. Barrel is free standing large container for storing the feed. The bottom of the barrel forms a funnel for conducting the food into a spinner plate. A spinner plate is disposed directly below the funnel of the barrel. An elongated shaft extends vertically upward through the spinner plate and into the funnel of the barrel. A control unit containing an operationally timer is positioned below the spinner plate. The timer is set to come on at predetermined intervals throughout the day. When the timer in the control unit comes on, the shaft rotates within the funnel thereby facilitating the conduction of the feed into the spinner plate.

Abstract: The present invention, an automatic animal feeder, comprises a barrel, spinner plate, and control unit. Barrel is free standing large container for storing the feed. The bottom of the barrel forms a funnel for conducting the food into a spinner plate. A spinner plate is disposed directly below the funnel of the barrel. An elongated shaft extends vertically upward through the spinner plate and into the funnel of the barrel. A control unit containing an operationally timer is positioned below the spinner plate. The timer is set to come on at predetermined intervals throughout the day. When the timer in the control unit comes on, the shaft rotates within the funnel thereby facilitating the conduction of the feed into the spinner plate.

Abstract: System, device and method for alerting an individual to an alert condition using acoustic alarms having less sensitivity to multipath distortion and having improved inherent signal to noise ratio properties, wherein the acoustic alarms are readily distinguishable using standard digital processing techniques.

Abstract: Compensating and identifying caps and cap assemblies for temporarily capping fittings. Each cap comprises a generally or pseudo cylindrically shaped member that includes a plurality of substantially planar panel segments contiguously connected to form a symmetrical polygonal cup-shape (e.g., a hexagon). One end is closed to complete the formation of the cup. Each cup has an outwardly flaring lip to facilitate mounting on a fitting, and the substantially planar panel segments slope inwardly slightly to facilitate molding and mounting. At the intersection of at least two of the panel segments, there are included resiliently expandable relief recesses so that if the member is force-fit mounted on a fitting slightly larger than its un-expanded dimensions, the material of the relief recesses expands correspondingly to permit such mounting. Pairs of such caps are connected by an easily frangible connecting strip to form assemblies which facilitate concurrent mounting on disengaged ends of tubing connectors.

Abstract: A versatile plastic cap assembly for plugging and/or protecting fittings comprising a joined pair of capping members, one of such capping members being adapted for snap fit onto a male fitting, and the other being adapted for snap fit onto a female fitting. The capping members are initially joined together with an easily breakable connector so as to retain them in pairs until put into use, at which time the two capping members may easily be separated as, for example by pulling or twisting. The invention also includes a method of retaining identification of and temporarily protecting ends of components adapted for connection or re-connection while the ends are disengaged.

Abstract: A child or infant stroller is provided which is convertible from an operative stroller position to a folded position adapted to be received by and secured on a conventional bicycle infant carrier. The stroller generally comprises a child or infant seat and a frame member supporting the infant seat. The frame member includes two pair of legs, one of which, preferably a front pair, is adapted to rotate and releasably engage with an upper portion of the frame member. The stroller can then be placed on the bicycle infant carrier and be secured by a belt included with the conventional bicycle infant carrier. A removable attachment may also be included which attaches the two pairs of legs together when the stroller is in its operative stroller position.

Abstract: This tool is for the placement and removal of "E" type, and hairpin type, clips, that are used on mechanical devices, such as carburetors on gasoline engines. It consists primarily of a handle with a shank having a pair of magnetic blades, one of which includes a tooth for removing a clip from linkage.