Patents by Inventor Joe T. R. Clarke

Joe T. R. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Products and methods for gaucher disease therpy
    Publication number: 20040082535
    Abstract: The invention relates to products and methods for medical treatment of Gaucher disease and, in particular, an improved Gcc DNA for insertion into any applicable expression vector for gene therapy treatment. The invention includes an isolated Gcc DNA molecule, wherein nucleic acid molecules have been modified at cryptic splice sites to prevent or decrease splicing of mRNA produced from the DNA molecule, while preserving the ability of the DNA to express functional Gcc polypeptides.
    Type: Application
    Filed: November 12, 2003
    Publication date: April 29, 2004
    Inventors: Don J. Mahuran, Joe T.R. Clarke, John W. Callahan
  • Products and methods for gaucher disease therapy
    Patent number: 6696272
    Abstract: The invention relates to products and methods for medical treatment of Gaucher disease and, in particular, an improved Gcc DNA for insertion into any applicable expression vector for gene therapy treatment. The invention includes an isolated Gcc DNA molecule, wherein nucleic acid molecules have been modified at cryptic splice sites to prevent or decrease splicing of mRNA produced from the DNA molecule, while preserving the ability of the DNA to express functional Gcc polypeptides.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: February 24, 2004
    Assignee: HSC Research & Development Limited Partnership
    Inventors: Don J. Mahuran, Joe T. R. Clarke, John W. Callahan