Abstract: The invention relates to methods of increasing the survival of dopamine secreting cells, comprising the steps of administering a retinoid X receptor (RXR) ligand to dopamine secreting cells, wherein the binding of the RXR ligand increases the survival of the dopamine secreting cells. Therapeutic approaches to neurodegenerative diseases are also disclosed.

Abstract: A man-machine interface device is provided which employs rigid links interconnected by measured revolute joints to provide the position of a hand relative to a reference location, such as a desk, keyboard or chair. By proper selection of kinematic structure, and by placing one of the joints near the elbow and extending one of the links along the line of the forearm, translation of the joint-link structure is minimized, hence the undesirable perception of friction and inertia are also minimized. When Hall-Effect sensors are used as the revolute joint goniometers, the permanent magnets of neighboring joints are placed in the same link so the effects of magnetic field interference can be calibrated out. A hand-sensing joint-link device as described herein can produce data which is more noise free, at a higher sample rate, with less latency and more robust that competing electromagnetic, optical and ultrasonic sensing technologies, without adding much encumbrance.