Abstract: The present invention provides a microchannel structure loaded with a bead having a particle size for detecting whether a biological substance exists in a sample. The microchannel structure includes a structure body for passing a sample through the microchannel structure to have a test or a treatment. The structure body includes a sample entrance having a first aperture to allow the sample passing therethrough, a resistance-increasing section connected with the sample entrance, and having a second aperture being smaller than the first aperture, a detecting section connecting with the resistance-increasing section, and a bead mooring structure coupled to the second end for mooring the bead in the detecting section. The present invention can be used to capture rare cells in a biological system, such as human blood.

Abstract: The present invention provides a microchannel structure loaded with a bead having a particle size for detecting whether a biological substance exists in a sample. The microchannel structure includes a structure body for passing a sample through the microchannel structure to have a test or a treatment. The structure body includes a sample entrance having a first aperture to allow the sample passing therethrough, a resistance-increasing section connected with the sample entrance, and having a second aperture being smaller than the first aperture, a detecting section connecting with the resistance-increasing section, and a bead mooring structure coupled to the second end for mooring the bead in the detecting section. The present invention can be used to capture rare cells in a biological system, such as human blood.

Abstract: The present invention provides a microchannel structure for removing circulating tumor cells in a circulating blood system without damaging cells in the blood, wherein the microchannel is loaded with a plurality of beads. The microchannel structure includes: a blood sample entrance passing a blood sample therethrough; a bead mooring section including: a first end connected to the blood sample entrance; a second end; a first section being relatively close to the first end, and cooperating with the first end to cause the plurality of beads to form a bead array in the bead mooring section for decreasing a flow rate of the blood sample through an interstice among neighboring ones of the plurality of beads; and a second section being relatively close to the second end, and causing the treated blood sample to smoothly flow therethrough; and a blood sample exit connected to the second end. One of the applications of this invention is to remove cancer cells in cancer patient's circulating blood system.

Abstract: A fluid control device includes a body having an inlet, an outlet, and a fluid flow path between the inlet and the outlet, a seat, and a control element that is coupled to a stem. The control element and the stem are movable along a first axis and biased toward a closed position in which the control element engages the seat. The fluid control device includes an actuator assembly including a shaft that is operatively coupled to the stem via a Scotch yoke mechanism such that rotation of the shaft in a first rotational direction causes movement of the stem and control element along the first axis in a first translational direction. The actuator assembly includes a trigger mechanism that is responsive to fluid pressure and prevents rotation of the shaft in a first mode of operation and releases the shaft to allow rotation in a second mode of operation.