Abstract: Delivery devices for delivering a self-expanding prosthetic heart valve are disclosed. The delivery device includes at least one cord is configured to selectively cinch the self-expanding prosthetic heart valve. The delivery device further includes at least one self-expanding release pin comprising a proximal segment, a distal segment, and an intermediate segment positioned between the proximal segment and the distal segment. The at least one self-expanding release pin includes a normal, expanded condition wherein the intermediate segment extends radially outward relative to a central axis of the spindle from the proximal segment to the distal segment. The delivery device further includes a capsule configured to be distally extended relative to the spindle to collapse the at least one self-expanding release pin from the normal, expanded condition of the at least one self-expanding release pin to a collapsed condition of the at least one self-expanding release pin.

Abstract: The invention is directed to methods of detecting lung, gastrointestinal tract, and systemic infections by measuring 13CO2/12CO2 isotopic ratios of gaseous carbon dioxide in exhaled breath samples of a subject after administration of a 13C-isotopically-labeled compound.

Abstract: An apparatus and method (and related kit) for determination of the isotopic ratio of 13C to 12C in a gas sample containing carbon dioxide comprising introducing gas into a gas sample chamber, directing light into the sample chamber from a laser light source, the laser light source being capable of accessing one or more of the wavelength pairs 2054.37 and 2052.42; 2054.96 and 2051.67; or 2760.53 and 2760.08 nanometers, and with a detector detecting the laser light energy after passage through the sample chamber.

Abstract: An apparatus and method for monitoring gas velocity, temperature, and pressure in combustion systems and flow devices, in particular at inlets and isolators of scramjet engines. The invention employs wavelength modulation spectroscopy with first harmonic detection and without the need to scan the full absorption spectra.

Abstract: An optical cell and a method of operating an optical cell comprising employing a first mirror comprising a first hole therein at approximately a center of the first mirror and through which laser light enters the cell, employing a second mirror comprising a second hole therein at approximately a center of the second mirror and through which laser light exits the cell, and forming a Lissajous pattern of spots on the mirrors by repeated reflection of laser light entering the cell.

Abstract: The present invention is a portable gas leak detector preferably comprising a portable optical spectroscopy apparatus for measurement of gas concentration.

Abstract: An optical spectroscopy apparatus and method for measurement of species concentration, number density, or column density comprising emitting light from a laser light source, receiving light via a fixed length optical path from the source and containing a species to be detected, receiving light via a detector at an end of the path, determining one or more of species concentration, number density, and column density via signal processing electronics connected to the detector, and switching between a plurality of operational modes measuring a same absorption feature of the species depending on measured absorbance.

Abstract: A multiple pass optical cell and method comprising providing a pair of opposed cylindrical mirrors having curved axes with substantially equal focal lengths, positioning an entrance hole for introducing light into the cell and an exit hole for extracting light from the cell, wherein the entrance hole and exit hole are coextensive or non-coextensive, introducing light into the cell through the entrance hole, and extracting light from the cell through the exit hole.

Abstract: An apparatus and method for monitoring oxygen concentrations in fuel tank ullage comprising providing a sensor head comprising an optical cavity, exposing the optical cavity to an ambient gaseous environment of a fuel tank or air separation module, via a laser light source emitting wavelength modulated light through the cavity, and receiving the wavelength modulated light with a detector.

Abstract: A multiple pass optical cell and method comprising providing a pair of opposed mirrors, one cylindrical and one spherical, introducing light into the cell via an entrance mechanism, and extracting light from the cell via an exit mechanism, wherein the entrance mechanism and exit mechanism are coextensive or non-coextensive.

Abstract: An absorption spectroscopy method comprising providing a sample in a container, rotating the container, while rotating the container, directing a beam of electromagnetic radiation through the container, the beam comprising one or more wavelengths selected from the group consisting of visible wavelengths, infrared wavelengths, and ultraviolet wavelengths, and measuring characteristics of the beam after it passes through the container. Also an absorption spectroscopy apparatus comprising a container holder, a drive rotating the container holder, means for, while rotating the container, directing a beam of electromagnetic radiation through the container, the beam comprising one or more wavelengths selected from visible wavelengths, infrared wavelengths, and ultraviolet wavelengths, and means for receiving the beam after passage through the container.

Abstract: A multiple pass optical cell and method comprising providing a pair of opposed cylindrical mirrors having curved axes with substantially equal focal lengths, positioning an entrance hole for introducing light into the cell and an exit hole for extracting light from the cell, wherein the entrance hole and exit hole are coextensive or non-coextensive, introducing light into the cell through the entrance hole, and extracting light from the cell through the exit hole.

Abstract: A multiple pass optical cell and method comprising providing a pair of opposed mirrors, one cylindrical and one spherical, introducing light into the cell via an entrance mechanism, and extracting light from the cell via an exit mechanism, wherein the entrance mechanism and exit mechanism are coextensive or non-coextensive.

Abstract: An apparatus and method for monitoring oxygen concentrations in fuel tank ullage comprising providing a sensor head comprising an optical cavity, exposing the optical cavity to an ambient gaseous environment of a fuel tank or air separation module, via a laser light source emitting wavelength modulated light through the cavity, and receiving the wavelength modulated light with a detector.

Abstract: Methods of treating cancer include contacting a cancer cell with 4-amino-5-fluoro-3-(5-piperazin-1-yl-1H-benzimidazol-2-yl)quinolin-2(1H)-one, 4-amino-5-fluoro-3-[5-(4-methyl-4-oxidopiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, tautomers thereof, pharmaceutically acceptable salts thereof, pharmaceutically acceptable salts of the tautomers thereof, or a mixture thereof.

Abstract: An external cavity laser (and method of generating laser light) comprising: a laser light source; means for collimating light output by the laser light source; a diffraction grating receiving collimated light; a cavity feedback mirror reflecting light received from the diffraction grating back to the diffraction grating; and means for reliably tuning the external cavity laser to discrete wavelengths.

Abstract: A system and method that enables a user to calibrate a display by presenting instructions to the user is described. This system and method can enable a user to calibrate a display by presenting instructions to the user that are based on the type or the connection type of display that the user is attempting to calibrate. It can also enable a user to more easily and intuitively calibrate his or her display by presenting a motion video tailored to help the user calibrate a parameter of the user's display.

Abstract: An external cavity laser (and method of generating laser light) comprising: a laser light source; means for collimating light output by the laser light source; a diffraction grating receiving collimated light; a cavity feedback mirror reflecting light received from the diffraction grating back to the diffraction grating; and means for reliably tuning the external cavity laser to discrete wavelengths.

Abstract: A photoacoustic spectroscopy method and apparatus for maintaining an acoustic source frequency on a sample cell resonance frequency comprising: providing an acoustic source to the sample cell, the acoustic source having a source frequency; repeatedly and continuously sweeping the source frequency across the resonance frequency at a sweep rate; and employing an odd-harmonic of the source frequency sweep rate to maintain the source frequency sweep centered on the resonance frequency.

Abstract: A photoacoustic spectroscopy method and apparatus for maintaining an acoustic source frequency on a sample cell resonance frequency comprising: providing an acoustic source to the sample cell to generate a photoacoustic signal, the acoustic source having a source frequency; continuously measuring detection phase of the photoacoustic signal with respect to source frequency or a harmonic thereof; and employing the measured detection phase to provide magnitude and direction for correcting the source frequency to the resonance frequency.