Patents by Inventor Joel B. Grae
Joel B. Grae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7601377Abstract: An method for processing a fluid, having a vacuum chamber having an associated heater, to heat a condensable gas therewithin, a spray nozzle to atomize a cool fluid, having a non-condensible gas dissolved therewithin, a vacuum line to maintain reduced pressure in the vacuum chamber and remove non-condensing gas, and a control, for maintaining steady state conditions in the vacuum chamber by controlling pressure and temperature conditions. Gases condenses on the atomized droplets to release a latent heat of vaporization.Type: GrantFiled: May 2, 2006Date of Patent: October 13, 2009Assignee: Millisecond Technologies Corp.Inventors: Yuri Vasilvevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
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Patent number: 7449314Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.Type: GrantFiled: June 17, 2003Date of Patent: November 11, 2008Assignee: IB2, LLCInventor: Joel B. Grae
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Patent number: 7037694Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.Type: GrantFiled: June 24, 2002Date of Patent: May 2, 2006Assignee: I. Belloch Corp.Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
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Publication number: 20040023351Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.Type: ApplicationFiled: June 17, 2003Publication date: February 5, 2004Inventor: Joel B. Grae
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Patent number: 6579706Abstract: A system and method for processing a cells, the method comprising the steps of providing the cells to be processed in a liquid medium; and heating the liquid medium containing the cells at a rate and through a range sufficient to cause an instability in at least one of the cellular membranes. The method may be used to fuse the structure with another membranes, or to reduce the integrity of the membranes. The system atomizes a medium containing the cells into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.Type: GrantFiled: August 17, 2001Date of Patent: June 17, 2003Assignee: IB2, LLCInventor: Joel B. Grae
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Publication number: 20030035752Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.Type: ApplicationFiled: June 24, 2002Publication date: February 20, 2003Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
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Publication number: 20020168734Abstract: A system and method for processing a lipid membrane bound structure. the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.Type: ApplicationFiled: August 17, 2001Publication date: November 14, 2002Inventor: Joel B. Grae
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Patent number: 6410284Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that or organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.Type: GrantFiled: October 4, 1999Date of Patent: June 25, 2002Assignee: I. Belloch Corp.Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
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Patent number: 6277610Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and beating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.Type: GrantFiled: March 17, 2000Date of Patent: August 21, 2001Assignee: IB2, LLCInventor: Joel B. Grae
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Patent number: 5962288Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.Type: GrantFiled: March 5, 1997Date of Patent: October 5, 1999Assignee: Belloch Corp.Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasiyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
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Patent number: 5914255Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.Type: GrantFiled: March 5, 1997Date of Patent: June 22, 1999Inventor: Joel B. Grae