Patents by Inventor Joel B. Grae

Joel B. Grae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7601377
    Abstract: An method for processing a fluid, having a vacuum chamber having an associated heater, to heat a condensable gas therewithin, a spray nozzle to atomize a cool fluid, having a non-condensible gas dissolved therewithin, a vacuum line to maintain reduced pressure in the vacuum chamber and remove non-condensing gas, and a control, for maintaining steady state conditions in the vacuum chamber by controlling pressure and temperature conditions. Gases condenses on the atomized droplets to release a latent heat of vaporization.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: October 13, 2009
    Assignee: Millisecond Technologies Corp.
    Inventors: Yuri Vasilvevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
  • Patent number: 7449314
    Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: November 11, 2008
    Assignee: IB2, LLC
    Inventor: Joel B. Grae
  • Patent number: 7037694
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: May 2, 2006
    Assignee: I. Belloch Corp.
    Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
  • Publication number: 20040023351
    Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.
    Type: Application
    Filed: June 17, 2003
    Publication date: February 5, 2004
    Inventor: Joel B. Grae
  • Patent number: 6579706
    Abstract: A system and method for processing a cells, the method comprising the steps of providing the cells to be processed in a liquid medium; and heating the liquid medium containing the cells at a rate and through a range sufficient to cause an instability in at least one of the cellular membranes. The method may be used to fuse the structure with another membranes, or to reduce the integrity of the membranes. The system atomizes a medium containing the cells into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: June 17, 2003
    Assignee: IB2, LLC
    Inventor: Joel B. Grae
  • Publication number: 20030035752
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Application
    Filed: June 24, 2002
    Publication date: February 20, 2003
    Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
  • Publication number: 20020168734
    Abstract: A system and method for processing a lipid membrane bound structure. the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.
    Type: Application
    Filed: August 17, 2001
    Publication date: November 14, 2002
    Inventor: Joel B. Grae
  • Patent number: 6410284
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2° C. at a rate which exceeds a relaxation rate of a cellular membrane of that or organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: June 25, 2002
    Assignee: I. Belloch Corp.
    Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasilyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
  • Patent number: 6277610
    Abstract: A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and beating the liquid medium containing the structure at a rate and through a range sufficient to cause a discrete phase transition in at least one of the membranes, such that the membranes fuse. The method may be used to fuse the structure with another structure, or to reduce the integrity of the structure. The apparatus atomizes a medium containing the structure into small droplets and subjects them to an environment containing steam vapor while moving at high velocity, to rapidly increase the droplet temperature to the steam temperature by release of the latent heat of vaporization.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: August 21, 2001
    Assignee: IB2, LLC
    Inventor: Joel B. Grae
  • Patent number: 5962288
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins. A method is also provided for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: October 5, 1999
    Assignee: Belloch Corp.
    Inventors: Yuri Vasilyevich Aksenov, Michael Nikolaevich Ivanovsky, Nikolai Ivanovich Loginov, Albina Vasiyevna Milovidova, Valentine Alexeevich Morozov, Nikolai Nikolaevich Ponomarev-Stepnoi, Boris Alexandrovich Chulkov, Alexander Lvovich Shimkevich, Joel B. Grae
  • Patent number: 5914255
    Abstract: A method for treating a biological organism in a medium, comprising heating the medium containing the organism by a temperature of at least about 2.degree. C. at a rate which exceeds a relaxation rate of a cellular membrane of that organism, under such time and temperature conditions which do not thermally denature a substantial portion of the biological proteins.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: June 22, 1999
    Inventor: Joel B. Grae