Patents by Inventor Joel C. Barrish

Joel C. Barrish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic protein tyrosine kinase inhibitors
    Publication number: 20040073026
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: March 3, 2003
    Publication date: April 15, 2004
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Publication number: 20040067989
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Application
    Filed: August 15, 2003
    Publication date: April 8, 2004
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Publication number: 20040067990
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Application
    Filed: August 15, 2003
    Publication date: April 8, 2004
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch
  • Cyclic protein tyrosine kinase inhibitors
    Publication number: 20040054186
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: March 24, 2003
    Publication date: March 18, 2004
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak, Louis J. Lombardo, Francis Y.F. Lee
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Patent number: 6706717
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: March 16, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch, III
  • Cyclic protein tyrosine kinase inhibitors
    Publication number: 20040024208
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: March 3, 2003
    Publication date: February 5, 2004
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Imidazoquinoxaline protein tyrosine kinase inhibitors
    Patent number: 6635626
    Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: October 21, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 6596746
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: July 22, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Publication number: 20030069238
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Application
    Filed: December 20, 2001
    Publication date: April 10, 2003
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch
  • Benzothiazole protein trosine kinase inhibitors
    Publication number: 20020123484
    Abstract: Novel benzothiazoles and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Application
    Filed: October 26, 2001
    Publication date: September 5, 2002
    Inventors: Jagabndhu Das, Joel C. Barrish, John Wityak
  • Inhibitors of IMPDH enzyme
    Patent number: 6420403
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: July 16, 2002
    Inventors: Edwin J. Iwanowicz, T. G. Murali Dhar, Katerina Leftheris, Chunjian Liu, Toomas Mitt, Scott H. Watterson, Joel C. Barrish
  • Substituted biphenysulfonamide endothelin antagonists
    Patent number: 6271248
    Abstract: Compounds of the formula wherein X, Y, R1, R2, R3, R4 and R5 are as described herein, inhibit the activity of endothelin.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: August 7, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Natesan Murugesan, Joel C. Barrish, John Lloyd
  • Imidazoquinoxaline protein tyrosine kinase inhibitors
    Patent number: 6239133
    Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: May 29, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Steven H. Spergel
  • Imidazoquinoxaline protein tyrosine kinase inhibitors
    Patent number: 6235740
    Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 22, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joel C. Barrish, Ping Chen, Jagabandhu Das, Edwin J. Iwanowicz, Derek J. Norris, Ramesh Padmanabha, Jacques Y. Roberge, Gary L. Schieven
  • Substituted biphenylsulfonamide endothelin antagonists
    Patent number: 6080774
    Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: ##STR2## R.sup.2 and R.sup.3 are each independently (a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.6 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ;(i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ;(j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or(k) --Z.sup.4 --N(R.sup.11)--Z.sup.5 --NR.sup.9 R.sup.10 ;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: June 27, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Natesan Murugesan, Joel C. Barrish, John Lloyd
  • Isoxazolyl endothelin antagonists
    Patent number: 6043265
    Abstract: The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methy l]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: March 28, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Natesan Murugesan, Joel C. Barrish, Zhengxiang Gu, Richard A. Morrison
  • Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors
    Patent number: 5990109
    Abstract: Novel heterocyclo-substituted imidazopyrazines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: November 23, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ping Chen, Derek J. Norris, Joel C. Barrish, Edwin J. Iwanowicz
  • Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
    Patent number: 5939446
    Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: August 17, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Natesan Murugesan, Joel C. Barrish
  • Substituted biphenyl isoxazole sulfonamides
    Patent number: 5846990
    Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each directly bonded to a ring carbon and are each independently(a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.5 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.5 ;(i) --Z.sup.4 --NR.sup.6 R.sup.7 ;(j) --Z.sup.4 --N(R.sup.10)--Z.sup.5 --NR.sup.8 R.sup.9 ; or(k) R.sup.3 and R.sup.4 together may also be alkylene or alkenylene, either of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3, completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: December 8, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Natesan Murugesan, Joel C. Barrish, Steven H. Spergel
  • Substituted biphenyl sulfonamide endothelin antagonists
    Patent number: 5780473
    Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: July 14, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Natesan Murugesan, Joel C. Barrish, Philip D. Stein