Abstract: Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.

Abstract: An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: Methods for treating a tissue defect include applying therapeutic compositions to the tissue defect. Treatment of a tissue defect, including wound healing can be enhanced by a process including obtaining blood compatible with the subject, fractionating the blood from the subject to produce a blood component, obtaining stromal cells from the subject, combining the stromal cells and the blood component to form a therapeutic composition, and delivering the therapeutic composition to the tissue defect. Therapeutic compositions for promoting wound healing include isolated stromal cells and a blood component.

Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: The present teachings provide for a prosthetic implant comprising a femoral component, a tibial component, a bearing and a wear reduction device. The femoral component is operable to replace at least a portion of a patient's natural femur. The tibial component is operable to replace at least a portion of a patient's natural tibia, the tibial component having a superior tibial component surface. The bearing is operable to provide engagement between the femoral component and the tibial component. The bearing has a superior bearing surface operable to articulate with the femoral component and an inferior bearing surface operable to cooperate with the superior tibial component surface. The wear reduction device is located at least one of the superior tibial component surface and the inferior bearing surface and is operable to reduce wear upon at least one of the superior tibial component surface and the inferior bearing surface.

Abstract: A method and apparatus for enabling access to an intramedullary canal of a femur through a femoral knee joint prosthesis includes a first condylar portion and a second condylar portion. The first condylar portion has a first femoral bearing surface and the second condylar portion has a second femoral bearing surface. An intercondylar portion extends between the first condylar portion and the second condylar portion and defines an opening passing therethrough. A seal member is operable to substantially seal the opening such that the seal member is further operable to be opened to enable access to the intramedullary canal of the femur without having to remove the femoral knee joint prosthesis from the femur. A method for enabling access to the intramedullary canal of the femur through the femoral knee joint prosthesis is also provided.

Abstract: A method for forming products includes the step of forming an incompletely consolidated stock from a powder. A substantially completely consolidated stock is then formed from the incompletely consolidated stock. Finally, the substantially completely consolidated stock is machined to form the final product. The method of the present invention also includes a method for recycling waste thermoplastic materials into useful articles. The method of the present invention also includes a method for processing thermoplastics, thermosets and elastomers. As part of the above, an elastomeric mold may be used, which may be formed from a mandrel.

Abstract: A method for forming biocompatible components from a stock of substantially completely consolidated material. The method includes the step of forming an incompletely consolidated stock from a powder. The substantially completely consolidated stock is then formed from the incompletely consolidated stock. Finally, the substantially completely consolidated stock is then machined to form the biocompatible component.

Abstract: A method for forming a biocompatible component from a biocompatible thermoplastic material and a biocompatible fibrous material using an isostatic press. The method includes the steps of placing the biocompatible thermoplastic material and the biocompatible fibrous material in a flexible container. The flexible container is then heated under pressure so as to cause the biocompatible thermoplastic material to encapsulate the biocompatible fibrous material. The flexible container is then cooled so as to form the biocompatible component.

Abstract: A method for forming biocompatible components from a stock of substantially completely consolidated material. The method includes the step of forming an incompletely consolidated stock from a powder. The substantially completely consolidated stock is then formed from the incompletely consolidated stock. Finally, the substantially completely consolidated stock is then machined to form the biocompatible component.

Abstract: A method for treating orthopedic implants subject to wear and fatigue, and an orthopedic implant device treated in accordance with the described method. The orthopedic implant device is initially located in a reaction vessel. The outer surface of the orthopedic implant device is then subject to plasma nitriding so as to form a nitrogen enriched layer on the outer surface of the orthopedic implant device.