Abstract: There is provided a downhole sucker rod pump comprising: a plunger, a housing including an inner surface, a housing passage defined by the inner surface, and a recess defined within the inner surface of the housing. The plunger and the housing are co-operatively configured such that the plunger is operable for reciprocating movement through the housing passage, with effect that: the plunger traverses a plunger-traversable section of the inner surface of the housing, and solids-comprising reservoir fluid material is displaceable in an uphole direction via the housing passage. At least a portion of the recess is a plunger-traversable recess, and the plunger-traversable recess portion is defined within the plunger-traversable section, the housing passage includes a downhole space disposed downhole relative to the plunger-traversable section, and the plunger-traversable recess portion is disposed in flow communication with the downhole space.

Abstract: A drill hole logging system (5) incorporates a computing system (58) at the surface and a deployment mechanism (40) for conveying a logging tool (10) configured to measure one or more geophysical parameters into a drill hole (20). A transmission means (57) communicates commands and data representing the geophysical parameters between the surface computing system and the logging tool. A borehole caliper (300) is employed to profile the inside of the borehole.

Abstract: The present disclosure describes near-eye display systems including an array of projectors and a one-dimensional exit pupil expander. The array of projectors can be arranged along a first dimension and can output image light towards an input coupler within a waveguide that provides one-dimensional exit pupil expansion. In some implementations, arrays of monochromatic projectors are implemented and arranged in offset columns. The input coupler in-couples the image light from the array of projectors into a TIR path within the waveguide. Different optical elements, including diffractive and reflective optics, may be implemented as the input coupler. The image light travels within the waveguide until it interacts with an output coupler. Upon interaction with the output coupler, the image light is expanded in a second dimension transverse to the first dimension and is coupled out of the waveguide.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: A dishwashing appliance includes a tub, a fluid circulation system, and a heating assembly positioned outside of the tub. The heating assembly includes a housing and a tubular heating element disposed within the housing. The tubular heating element includes an inner surface and an outer surface. The inner surface of the tubular heating element defines a first passage in fluid communication with the fluid circulation system. The outer surface of the tubular heating element is spaced apart from an inner surface of the housing such that a second passage is defined between the outer surface of the tubular heating element and the inner surface of the housing. The second passage is in fluid communication with the tub. A resistive heating material is disposed on the outer surface of the tubular heating element. The resistive heating material is configured to provide thermal energy to the first passage and the second passage.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: A clutch assembly includes a drive shaft extending along an axial direction, and an output component, the output component defining a central opening in which the drive shaft is inserted. The clutch assembly further includes a clutch selectively coupling the output component to the drive shaft. The clutch includes a cavity defined in the output component and in communication with the central opening. The clutch further includes a bearing disposed within the cavity, the bearing movable within the cavity between a first position and a second position. The bearing is spaced from the drive shaft in the first position. The bearing contacts an inner surface of the output component defining the cavity and contacts the drive shaft to transfer rotational motion from the drive shaft to the output component in the second position.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: A dishwasher appliance includes a tub defining a wash chamber with a sump positioned at a bottom of the wash chamber for receiving fluid from the wash chamber. A filtering system is positioned between the wash chamber and an outlet of the sump portion. The filtering system includes a first filter and a second filter. The second filter includes a hollow annular base portion and a filter body extending between the base portion and the first filter. The second filter also includes a plurality of nozzles circumferentially arranged about the hollow annular base portion, each nozzle of the plurality of nozzles in fluid communication with the hollow annular base portion and oriented towards the filter body for cleaning the filter body. An inlet in fluid communication with the hollow annular base portion may also be provided.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: A dishwasher appliance is provided having a disk diverter assembly operably coupled to a primary supply conduit for selectively diverting a flow of wash fluid between a middle spray assembly and an upper spray assembly. The disk diverter assembly includes a diverter disk positioned within a diverter housing defining a fluid inlet, a first fluid outlet in fluid communication with the middle spray assembly, and a second fluid outlet in fluid communication with the upper spray assembly. The diverter disk defines an aperture and a partial flange that extends along an axial direction. A positioning assembly selectively rotates the diverter disk between a first position where wash fluid is directed only through the first fluid outlet to the middle spray assembly and a second position where wash fluid is directed only through the second fluid outlet to the upper spray assembly.