Patents by Inventor JOEL COLLIER

JOEL COLLIER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBLINGUAL NANOFIBER VACCINES AND METHODS OF MAKING AND USING SAME
    Publication number: 20250381256
    Abstract: Embodiments are directed to a UPEC conjugate peptide including a self-assembling peptide and at least one UPEC epitope. The UPEC conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the UPEC conjugate peptide may be used to treat a bacterial infection such as a urinary tract infection (UTI). The compositions and methods may be specific for pathogenic bacteria. The compositions and methods may treat the infection without altering the gut microbiome.
    Type: Application
    Filed: July 5, 2023
    Publication date: December 18, 2025
    Inventors: Joel Collier, Sean Kelly
  • TABLETIZATION OF PEPTIDE SELF-ASSEMBLIES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20250381144
    Abstract: The present disclosure provides, in part, peptide self-assemblies that are made into tablet form and methods of making and using the same. In some embodiments, the disclosure provides methods and formulations for a tabletized form of a vaccine, particularly a vaccine comprising self-assembling peptide-polymer nanofibers, an excipient and an adjuvant. Methods of making and using the tablet formulation are also provided.
    Type: Application
    Filed: April 3, 2025
    Publication date: December 18, 2025
    Inventors: Joel COLLIER, Sean KELLY
  • COMPOSITIONS AND METHODS FOR ANTI-PHOSPHOCHOLINE ACTIVE IMMUNOTHERAPY
    Publication number: 20250281629
    Abstract: Embodiments are directed to a phosphorylcholine (PC)-conjugate peptide including a self-assembling peptide and at least one PC molecule. The PC-conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the PC-conjugate peptide may be used to elicit an immune response, such as stimulating B1a cells to produce antibodies. The compositions may be used to treat an inflammatory disease such as inflammatory bowel disease (IBD) or ulcerative colitis. The compositions may also be used to alter the gut microbiome.
    Type: Application
    Filed: April 25, 2023
    Publication date: September 11, 2025
    Inventors: Joel Collier, Elizabeth Curvino
  • NANOFIBERS TO PRIME ANTIBODY RESPONSES AND METHODS OF USING SAME
    Publication number: 20250276058
    Abstract: Embodiments are directed to nanofiber compositions comprising antigens, such as the fusion peptide (FP) of HIV-1 trimers. The compositions may be used as vaccines themselves, or they may be used in combination with vaccines to enhance the immune response and increase antibody titers.
    Type: Application
    Filed: September 20, 2022
    Publication date: September 4, 2025
    Inventors: Chelsea Fries, Genevieve Fouda, Joel Collier
  • Tabletization of peptide self-assemblies and methods of making and using the same
    Patent number: 12290603
    Abstract: The present disclosure provides, in part, peptide self-assemblies that are made into tablet form and methods of making and using the same. In some embodiments, the disclosure provides methods and formulations for a tabletized form of a vaccine, particularly a vaccine comprising self-assembling peptide-polymer nanofibers, an excipient and an adjuvant. Methods of making and using the tablet formulation are also provided.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: May 6, 2025
    Assignee: Duke University
    Inventors: Joel Collier, Sean Kelly
  • TABLETIZATION OF PEPTIDE SELF-ASSEMBLIES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220362159
    Abstract: The present disclosure provides, in part, peptide self-assemblies that are made into tablet form and methods of making and using the same. In some embodiments, the disclosure provides methods and formulations for a tabletized form of a vaccine, particularly a vaccine comprising self-assembling peptide-polymer nanofibers, an excipient and an adjuvant. Methods of making and using the tablet formulation are also provided.
    Type: Application
    Filed: September 28, 2020
    Publication date: November 17, 2022
    Inventors: Joel COLLIER, Sean KELLY
  • SUPRAMOLECULAR POLYPEPTIDE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220194989
    Abstract: The present disclosure provides a supramolecular (self-assembling) polypeptide complex that comprises a plurality of randomized polyamino acids that self-assemble into nanofibers and methods of making and using same.
    Type: Application
    Filed: May 4, 2020
    Publication date: June 23, 2022
    Inventors: Joel COLLIER, Nicole VOTAW
  • COMPOSITIONS COMPRISING SUPRAMOLECULAR NANOFIBER HIV ENVELOPES AND METHODS FOR THEIR USE
    Publication number: 20220040290
    Abstract: The technology provides immunogenic compositions comprising HIV-1 envelopes in supramolecular nanofiber complexes, which may also comprise a T-cell helper epitopes, and methods of using these compositions for induction of immune responses.
    Type: Application
    Filed: September 24, 2019
    Publication date: February 10, 2022
    Inventors: Sallie PERMAR, Joel COLLIER, Kevin O. SAUNDERS, Chelsea FRIES, Fouda Amou'ou Genevieve GINY
  • METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS
    Publication number: 20160074488
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 17, 2016
    Inventors: Joel Collier, Gregory Hudalla
  • Methods and compositions involving fibrillizing polypeptides for nanofibers
    Patent number: 9200082
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 1, 2015
    Assignee: The University of Chicago
    Inventors: Joel Collier, Gregory Hudalla
  • METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS
    Publication number: 20140273148
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: JOEL COLLIER, GREGORY HUDALLA