Abstract: A fountain pen that is configured to be reloaded with ink wherein the fountain pen of the present invention has an improved volume capacity over conventional fountain pens. The invention includes a body wherein the body includes a grip portion and a barrel portion that are rotatably coupled. A nib is secured to the first end of the body. A rod member is mounted within the interior volume of the body and extends the length thereof. A piston head member is operably coupled to the rod member and is configured to traverse therealong during rotation of the barrel portion of the body. The wall member of the barrel portion of the body includes movement members formed thereon. The perimeter edge of the piston head member is sealably and operably coupled with the movement members and wherein movement of the piston head member facilitates the drawing of ink into the body.

Abstract: The articulated multiple-axis robot structure has a frame, an arm and a forearm, a shaft for attaching a tool, an actuator commanding the pivoting of a slide-socket, an actuator commanding the pivoting, a rotatable nut-socket, and a coupling device for securing the sockets in rotation. The coupling device having a coupling washer between the sockets and connected in rotation with one of the slide-socket and the nut-socket. The coupling washer is movable between a coupling configuration, in which the translation of the shaft relative to the forearm is locked, and an operating configuration, in which the translation and rotation of the shaft relative to the forearm are freed by a first electromagnet.

Abstract: The articulated multiple-axis robot structure according to the invention has a frame, an arm and a forearm, a shaft (15) for attaching a tool, an actuator commanding the pivoting of a slide-socket (14A), which is rotatable relative to the forearm and translatably connected to the forearm, an actuator commanding the pivoting a nut-socket (14B) that is rotatable relative to the forearm and connected in translation to the forearm and a coupling device capable of securing the sockets (14A, 14B) in rotation. This device comprises a coupling washer (18), arranged between the sockets (14A, 14B) and connected in rotation with a first socket from among the slide-socket (14A) and the nut-socket (14B).

Abstract: This invention pertains to methods for promoting stable and site-specific integration of rep deleted recombinant adeno-associated virus vectors which result in less variable transgene expression and increased safety. These vectors are useful for delivery of a functional gene product to the desired intracellular location.

Abstract: This invention pertains to methods for promoting stable and site-specific integration of rep deleted recombinant adeno-associated virus vectors which result in less variable transgene expression and increased safety. These vectors are useful for delivery of a functional gene product to the desired intracellular location.