Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.

Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, the products from the molecule groups obtained and the application thereof in order to identify molecules that are capable of binding selectively to a tissue or a particular organ. The inventive method can be used for the development of novel therapeutic compounds and contrast agents for medical imaging and for the screening of medicaments.

Abstract: The invention relates to the use of phosphinic pseudopeptide derivatives for production of a medicament for selectively inhibiting the active C-terminal site of angiotensin I converting enzyme. These derivatives are of formula (II): where, R1 may be a protecting group for amino functions usually used in peptide chemistry or an amino acid or a peptide protected by the above type of protecting groups, R2 and R3 correspond to a natural or unnatural amino acid side chain and R4 and R5 represent a hydrogen atom or a counterion.

Abstract: This invention is used for creating straight marks along floor coverings to guarantee that they can be cut perfectly to the dimensions of the area. The template has two straight edges that function as rulers. Both of these edges are hinged and are parallel to each other. The hinges allow the tool to be adjusted to fit and mark any area. In the center, between the hinged bars, there is a pencil holding plate that holds the scribing tool. This pencil is held in place by an adjustable wing nut enabling the pencil to be manipulated as necessary. Alternatively, in the second embodiment, the center plate may include graduated holes for accepting the pencil. Finally, the entire apparatus includes rolling wheels, allowing it to easily move along edges and mark the floor coverings.

Abstract: The invention relates to the use of phosphinic pseudopeptide derivatives for production of a medicament for selectively inhibiting the active C-terminal site of angiotensin I converting enzyme. These derivatives are of formula (II): where, R1 may be a protecting group for amino functions usually used in peptide chemistry or an amino acid or a peptide protected by the above type of protecting groups, R2 and R3 correspond to a natural or unnatural amino acid side chain and R4 and R5 represent a hydrogen atom or a counterion. Applications: prevention and treatment of cardiovascular diseases in humans.

Abstract: The invention relates to peptide derivatives that can be used as selective inhibitors of the N-terminal site of human angiotensin-converting enzyme. The derivatives comprise the amino acid sequence with the following formula: -Asp-Phe-&PSgr;(PO2CH2)-Ala-Xaa′-  (I) wherein: &PSgr;(PO2CH2) indicates that the peptide bond (CONH) between Phe and Ala has been replaced by the phosphonic bond PO2CH2, and Xaa′ represents an amino acid residue. They can be used in pharmaceutical formulations, particularly to protect haematopoietic strain cells of patients undergoing aggressive chemotherapy or radiotherapy treatment.