Patents by Inventor Joel E. Huber

Joel E. Huber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process to produce midazolam
    Patent number: 5831089
    Abstract: The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: November 3, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventor: Joel E. Huber
  • Reduction method for substituted 5-methylene-thiazolidinediones
    Patent number: 5585495
    Abstract: The present invention provides a method for making known pharmaceutical compounds. More particularly the present invention provides a new reduction method for making thiazolidinedione derivatives, particularly ciglitazone, pioglitazone, and englitazone. This reduction method comprises reacting a compound of the formula II with a cobalt ion, a ligand and a reducing agent to achieve a compound of the formula I.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: December 17, 1996
    Assignee: The Upjohn Company
    Inventor: Joel E. Huber
  • 9.alpha.-dehalogenation process
    Patent number: 5426198
    Abstract: The present invention involves improved processes for the dehalogenation of 9.alpha.-halosteroids (I) ##STR1## to produce the corresponding 11.beta.-hydroxy steroids (II) ##STR2## which are known to be useful as pharmaceutical, where the improvements comprise (1) adding the 9.alpha.-halo steroid (I) to the chromium and (2) using catalytic amounts of chromium in the presence of a means of converting chromium (II) to chromium (III).
    Type: Grant
    Filed: January 31, 1990
    Date of Patent: June 20, 1995
    Assignee: The Upjohn Company
    Inventors: Joel E. Huber, Jeffrey A. Fleming
  • 16.alpha.-methylation process
    Patent number: 4990612
    Abstract: Disclosed is a process for the production of a .DELTA..sup.17(20) -steroid of the formula ##STR1## which comprises starting with a 16-unsaturated corticoid of the formula ##STR2## and contacting the 16-unsaturated corticoid (I) with a methylating agent in the presence of a copper catalyst and a silylating agent.
    Type: Grant
    Filed: December 5, 1988
    Date of Patent: February 5, 1991
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • 16.alpha.-methylation process
    Patent number: 4929395
    Abstract: C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA..sup.17 (.sup.20)-20-silyl ether.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: May 29, 1990
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • 17.beta.-cyano-9.alpha.,17.alpha.-dihydroxyandrost-4-en-3-one
    Patent number: 4921638
    Abstract: The invention is the compound 17.beta.-cyano-9.alpha., 17.alpha.-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17.alpha.-halo silyl ethers (II).
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: May 1, 1990
    Assignee: The Upjohn Company
    Inventors: Douglas A. Livingston, Bruce A. Pearlman, Scott Denmark, Joel E. Huber
  • 16.alpha.-methyl-17.alpha. 20-epoxysteroid and process
    Patent number: 4891426
    Abstract: C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA.17(20)-20-silyl ether.
    Type: Grant
    Filed: December 15, 1988
    Date of Patent: January 2, 1990
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • 16.alpha.-methylated.DELTA.17(20)-corticoids
    Patent number: 4704455
    Abstract: C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA..sup.17 (.sup.20)-20-silyl ether.
    Type: Grant
    Filed: April 18, 1985
    Date of Patent: November 3, 1987
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • Process to prepare .alpha.-chloroalprazolam
    Patent number: 4663454
    Abstract: .alpha.-Halomethylbenzodiazepines (II) are produced by direct halogenation of methylbenzodiazepines (I) using sulfuryl halide.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: May 5, 1987
    Assignee: The Upjohn Company
    Inventor: Joel E. Huber
  • Process for preparation of 16 .alpha.-methyl corticoids from .DELTA..sup.16 -steroids
    Patent number: 4530795
    Abstract: This invention discloses a general process for the production of corticoids from respective steroid-type compounds having a double bond from C-16 to C-17. The invention provides a viable alternative synthesis of 17.alpha.-hydroxy-progesterones and like corticoids.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: July 23, 1985
    Assignee: The Upjohn Company
    Inventor: Joel E. Huber
  • Grignard reagents prepared from 5-halopentan-2-one propylene ketals
    Patent number: 4400524
    Abstract: A process for preparing 19-norandrostenedione. Also provides key intermediates of 19-norandrostenedione and methods for preparing them in high yields.
    Type: Grant
    Filed: September 15, 1981
    Date of Patent: August 23, 1983
    Assignee: The Upjohn Company
    Inventor: Joel E. Huber
  • Non-aromatic oxygenated strong acid dehydration of 9.alpha.-hydroxyandrostenediones
    Patent number: 4127596
    Abstract: The present invention discloses a process for the production of androsta-4,9(11)-diene-3,17-dione type compounds from 9.alpha.-hydroxyandrostenedione type compounds by non-aromatic oxygenated strong acid dehydration.
    Type: Grant
    Filed: April 11, 1977
    Date of Patent: November 28, 1978
    Assignee: The Upjohn Company
    Inventors: John M. Beaton, Joel E. Huber, Amphlett G. Padilla, Max E. Breuer
  • Non-aromatic oxygenated strong acid dehydration of 9.alpha.-hydroxyandrostenediones
    Patent number: RE33364
    Abstract: The present invention discloses a process for the production of androsta-4,9(11)-diene-3,17-dione type compounds from 9.alpha.-hydroxyandrostenedione type compounds by non-aromatic oxygenated strong acid dehydration.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: October 2, 1990
    Assignee: The Upjohn Company
    Inventors: John M. Beaton, Joel E. Huber, Amphlett G. Padilla, Max E. Breuer