Abstract: Methods, systems, and apparatus for an infrared and visible imaging system. In some implementations, Image data from a visible-light camera is obtained. A position of a device is determined based at least in part on the image data from the visible-light camera. An infrared camera is positioned so that the device is in a field of view of the infrared camera, with the field of view of the infrared camera being narrower than the field of view of the visible-light camera. Infrared image data from the infrared camera that includes regions representing the device is obtained. Infrared image data from the infrared camera that represents the device is recorded. Position data is also recorded that indicates the location and pose of the infrared camera when the infrared image data is acquired by the infrared camera.

Abstract: A patient interface includes a hollow base with an air inlet configured to be connected to an air delivery tube and receive the pressurized flow of respiratory gas. The hollow base further includes a pair of nozzles extending from the hollow base. Each nozzle is configured to receive the pressurized flow of respiratory gas from a respective one of the pair of air outlets. A continuous flexible adhesive strip of material configured to adhere to a side of the patient's nose and support the hollow base and the pair of nozzles on the patient's face to form a sealed airpath from the hollow base to the patient's nasal airways. The hollow base comprises a first portion from which the pair of nozzles extend and a second portion that is attachable to the air delivery tube. The second portion is more rigid than the first portion.

Abstract: Methods, systems, and apparatus for an infrared and visible imaging system. In some implementations, Image data from a visible-light camera is obtained. A position of a device is determined based at least in part on the image data from the visible-light camera. An infrared camera is positioned so that the device is in a field of view of the infrared camera, with the field of view of the infrared camera being narrower than the field of view of the visible-light camera. Infrared image data from the infrared camera that includes regions representing the device is obtained. Infrared image data from the infrared camera that represents the device is recorded. Position data is also recorded that indicates the location and pose of the infrared camera when the infrared image data is acquired by the infrared camera.

Abstract: Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

Abstract: A flow transfer apparatus for transferring cooling flow from a primary gas flowpath to a turbine rotor. The apparatus includes a first supply plenum communicating with the primary gas flowpath and first inducers, the first inducers configured to accelerate a first fluid flow from the first supply plenum and discharge it toward the rotor with a tangential velocity; a second supply plenum communicating with the primary gas flowpath and second inducers, the second inducers configured to accelerate a second fluid flow from the second supply plenum towards the rotor with a tangential velocity; and a cooling modulation valve operable to selectively permit or block the second fluid flow from the primary gas flowpath to the second supply plenum. The valve includes a flow control structure disposed in the primary gas flowpath and an actuation structure extending to a location radially outside of a casing defining the primary gas flowpath.

Abstract: Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

Abstract: A gas turbine engine includes a turbomachine including a compressor section, a combustion section, a turbine section, and an exhaust section arranged in serial flow order and together defining at least in part a core air flowpath. The gas turbine engine also includes a thermal management system including a flowpath heat exchanger coupled to, or integrated into, one or more components of the compressor section, the combustion section, the turbine section, or the exhaust section such that the flowpath heat exchanger is directly thermally coupled to an airflow through the core air flowpath.

Abstract: The present disclosure is directed to a gas turbine engine defining a radial direction, a circumferential direction, an axial centerline along a longitudinal direction, and an upstream end and a downstream end along the longitudinal direction. The gas turbine engine defines a core flowpath extended generally along the longitudinal direction. The gas turbine engine includes a first turbine rotor. The first turbine rotor includes an annular outer band disposed outward of the core flowpath along the radial direction. The first turbine rotor further includes a plurality of airfoils coupled to an inner diameter of the outer band in which the plurality of airfoils are extended generally inward along the radial direction. The outer band defines a plurality of airfoil cooling passages in which the plurality of airfoil cooling passages are extended at least partially in the radial direction in fluid communication with the plurality of airfoils.

Abstract: A clearance control system includes one or more clearance control devices that include features for controlling the clearances between rotating and stationary components of an engine. In one exemplary aspect, a clearance control device utilizes a fluid to pressurize an actuation chamber defined by a compliant member of the clearance control device. The pressurization of the actuation chamber causes the actuation chamber to expand in a direction that changes the clearance between the stationary and rotating components of the engine.

Abstract: Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

Abstract: The present disclosure is directed to a gas turbine engine defining a radial direction, a longitudinal direction, and a circumferential direction, an upstream end and a downstream end along the longitudinal direction, and an axial centerline extended along the longitudinal direction. The gas turbine engine includes a low pressure (LP) turbine defining an outer flowpath. The outer flowpath defines a first outer flowpath radius at an upstream-most end of the LP turbine, a last outer flowpath radius disposed at a downstream-most end of the LP turbine, a middle outer flowpath radius disposed therebetween along the longitudinal direction. The middle outer flowpath radius is greater than the last outer flowpath radius.

Abstract: Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

Abstract: A gas turbine engine includes a turbomachine including a compressor section, a combustion section, a turbine section, and an exhaust section arranged in serial flow order and together defining at least in part a core air flowpath. The gas turbine engine also includes a thermal management system including a flowpath heat exchanger coupled to, or integrated into, one or more components of the compressor section, the combustion section, the turbine section, or the exhaust section such that the flowpath heat exchanger is directly thermally coupled to an airflow through the core air flowpath.

Abstract: The present disclosure is directed to a gas turbine engine defining a radial direction, a circumferential direction, an axial centerline along a longitudinal direction, and wherein the gas turbine engine defines an upstream end and a downstream end along the longitudinal direction, and wherein the gas turbine engine defines a core flowpath extended generally along the longitudinal direction. The gas turbine engine includes a turbine frame defined around the axial centerline, the turbine frame comprising a first bearing surface disposed inward along the radial direction. The gas turbine engine further includes a turbine rotor assembly including a bearing assembly coupled to the first bearing surface of the turbine frame and the turbine rotor assembly. The turbine rotor assembly further includes a first turbine rotor disposed upstream of the turbine frame and a second turbine rotor disposed downstream of the turbine frame.

Abstract: A flow transfer apparatus for transferring cooling flow from a primary gas flowpath to a turbine rotor. The apparatus includes a first supply plenum communicating with the primary gas flowpath and first inducers, the first inducers configured to accelerate a first fluid flow from the first supply plenum and discharge it toward the rotor with a tangential velocity; a second supply plenum communicating with the primary gas flowpath and second inducers, the second inducers configured to accelerate a second fluid flow from the second supply plenum towards the rotor with a tangential velocity; and a cooling modulation valve operable to selectively permit or block the second fluid flow from the primary gas flowpath to the second supply plenum. The valve includes a flow control structure disposed in the primary gas flowpath and an actuation structure extending to a location radially outside of a casing defining the primary gas flowpath.

Abstract: A flow transfer apparatus for transferring cooling flow from a primary gas flowpath to a turbine rotor. The apparatus includes a first supply plenum communicating with the primary gas flowpath and first inducers, the first inducers configured to accelerate a first fluid flow from the first supply plenum and discharge it toward the rotor with a tangential velocity; a second supply plenum communicating with the primary gas flowpath and second inducers, the second inducers configured to accelerate a second fluid flow from the second supply plenum towards the rotor with a tangential velocity; and a cooling modulation valve operable to selectively permit or block the second fluid flow from the primary gas flowpath to the second supply plenum. The valve includes a flow control structure disposed in the primary gas flowpath and an actuation structure extending to a location radially outside of a casing defining the primary gas flowpath.

Abstract: Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

Abstract: A clearance control system includes one or more clearance control devices that include features for controlling the clearances between rotating and stationary components of an engine. In one exemplary aspect, a clearance control device utilizes a fluid to pressurize an actuation chamber defined by a compliant member of the clearance control device. The pressurization of the actuation chamber causes the actuation chamber to expand in a direction that changes the clearance between the stationary and rotating components of the engine.

Abstract: The present disclosure is directed to a gas turbine engine defining a radial direction, a circumferential direction, an axial centerline along a longitudinal direction, and wherein the gas turbine engine defines an upstream end and a downstream end along the longitudinal direction, and wherein the gas turbine engine defines a core flowpath extended generally along the longitudinal direction. The gas turbine engine includes a turbine frame defined around the axial centerline, the turbine frame comprising a first bearing surface disposed inward along the radial direction. The gas turbine engine further includes a turbine rotor assembly including a bearing assembly coupled to the first bearing surface of the turbine frame and the turbine rotor assembly. The turbine rotor assembly further includes a first turbine rotor disposed upstream of the turbine frame and a second turbine rotor disposed downstream of the turbine frame.

Abstract: The present disclosure is directed to a gas turbine engine defining a radial direction, a longitudinal direction, and a circumferential direction, an upstream end and a downstream end along the longitudinal direction, and an axial centerline extended along the longitudinal direction. The gas turbine engine includes a low pressure (LP) turbine defining an outer flowpath. The outer flowpath defines a first outer flowpath radius at an upstream-most end of the LP turbine, a last outer flowpath radius disposed at a downstream-most end of the LP turbine, a middle outer flowpath radius disposed therebetween along the longitudinal direction. The middle outer flowpath radius is greater than the last outer flowpath radius.