Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a human Wiskott-Aldrich syndrome gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of WAS, including but not limited to, an immune system disorder, thrombocytopenia, eczema, X-linked thrombocytopenia (XLT), or X-linked neutropenia (XLN).

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a human BTK gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of X-linked agammaglobulinemia (XLA).

Abstract: A system includes a pump configured to pressurize a first fluid, and a pressure exchanger (PX). The PX is configured to receive a second fluid, to receive the pressurized first fluid, and to utilize the pressurized first fluid to pressurize the drilling mud for transport to a well.

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Abstract: A system includes a fluid injection system. The fluid injection system includes a rotary isobaric pressure exchanger (IPX) configured to receive a first fluid, to receive a second fluid extracted from a source well, to utilize the second fluid to pressurize the first fluid for injection into an injection well, and to inject the pressurized first fluid into the injection well.

Abstract: A system includes a fluid injection system. The fluid injection system includes a rotary isobaric pressure exchanger (IPX) configured to receive a first fluid, to receive a second fluid extracted from a source well, to utilize the second fluid to pressurize the first fluid for injection into an injection well, and to inject the pressurized first fluid into the injection well.

Abstract: A system includes a pump configured to pressurize a first fluid, and a pressure exchanger (PX). The PX is configured to receive a second fluid, to receive the pressurized first fluid, and to utilize the pressurized first fluid to pressurize the drilling mud for transport to a well.

Abstract: A system includes a fluid injection system. The fluid injection system includes a rotary isobaric pressure exchanger (IPX) configured to receive a first fluid, to receive a second fluid extracted from a source well, to utilize the second fluid to pressurize the first fluid for injection into an injection well, and to inject the pressurized first fluid into the injection well.

Abstract: A system includes an integrated manifold system including multiple isobaric pressure exchangers (IPXs) that each includes a low-pressure first fluid inlet, a high-pressure second fluid inlet, a high-pressure first fluid outlet, and a low-pressure second fluid outlet. The integrated manifold system includes a low-pressure first fluid manifold coupled to each of the low-pressure first fluid inlets and configured to provide low-pressure first fluid to each of the low-pressure first fluid inlets, a high-pressure second fluid manifold coupled to each of the high-pressure second fluid inlets and configured to provide high-pressure second fluid to each of the high-pressure second fluid inlets, a high-pressure first fluid manifold coupled to each of the high-pressure first fluid outlets and configured to discharge high-pressure first fluid, and a low-pressure second fluid manifold coupled to each of the low-pressure second fluid outlets and configured to discharge low-pressure second fluid.

Abstract: A mouthpiece and filter for smoking pipes. This pipe add-on effectively improves the smoking experience by it providing a filter at the end of a standard smoking pipe which filters out ash and other large particulates; and allowing for users to replace the mouthpiece when sharing a single pipe, limiting the transfer of diseases, resulting in a more sanitary experience.

Abstract: A system includes a fluid injection system. The fluid injection system includes a rotary isobaric pressure exchanger (IPX) configured to receive a first fluid, to receive a second fluid extracted from a source well, to utilize the second fluid to pressurize the first fluid for injection into an injection well, and to inject the pressurized first fluid into the injection well.

Abstract: A system includes an integrated manifold system including multiple isobaric pressure exchangers (IPXs) that each includes a low-pressure first fluid inlet, a high-pressure second fluid inlet, a high-pressure first fluid outlet, and a low-pressure second fluid outlet. The integrated manifold system includes a low-pressure first fluid manifold coupled to each of the low-pressure first fluid inlets and configured to provide low-pressure first fluid to each of the low-pressure first fluid inlets, a high-pressure second fluid manifold coupled to each of the high-pressure second fluid inlets and configured to provide high-pressure second fluid to each of the high-pressure second fluid inlets, a high-pressure first fluid manifold coupled to each of the high-pressure first fluid outlets and configured to discharge high-pressure first fluid, and a low-pressure second fluid manifold coupled to each of the low-pressure second fluid outlets and configured to discharge low-pressure second fluid.

Abstract: The dry cleaning machine according to the invention comprises: a rotating drum (1) disposed in an enclosed chamber (2); an air flow duct (3) in the form of a closed loop in association with the chamber (2); and a cooling circuit having a condenser (6) disposed in the air flow duct (3) downstream of an evaporator (10) and is characterized by a control circuit (11) comprising: an internal heat exchanger (12) interlaced at least to some extent with the condenser (6); and means (13) for controlling the flow of a fluid in the control circuit (11).