Patents by Inventor Joel Harris
Joel Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10689460Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: GrantFiled: September 8, 2016Date of Patent: June 23, 2020Assignee: Incube Labs, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
-
Publication number: 20200140151Abstract: A dome-shaped lid reversibly securably sealed to the rim of a container with two opposing drinking ports die-cut in the top wall of a brim mount. A reclosable fold-back hatch cover recessed within the brim mount rotates about a U-shaped hinge between a closed and opened position quickly and reliably. When the hatch cover is rotated to its opened position it creates a hatch opening of sufficient size to access the beverage for the following purposes, including, but not limited to, dunking a confection, letting steam escape to cool a hot beverage, adding condiments, stirring the beverage, or adding and removing toppings such as whipped cream on the surface of the beverage, performed with the lid remaining fixed to the container rim.Type: ApplicationFiled: December 20, 2019Publication date: May 7, 2020Inventor: Joel Harris
-
Publication number: 20200108020Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: ApplicationFiled: December 3, 2019Publication date: April 9, 2020Inventors: Mir Imran, Joel Harris
-
Patent number: 10604308Abstract: A dome-shaped lid reversibly securably sealed to the rim of a container with two opposing drinking ports die-cut in the top wall of a brim mount. A reclosable fold-back hatch cover recessed within the brim mount rotates about a U-shaped hinge between a closed and opened position quickly and reliably. When the hatch cover is rotated to its opened position it creates a hatch opening of sufficient size to access the beverage for the following purposes, including, but not limited to, dunking a confection, letting steam escape to cool a hot beverage, adding condiments, stirring the beverage, or adding and removing toppings such as whipped cream on the surface of the beverage, performed with the lid remaining fixed to the container rim.Type: GrantFiled: April 5, 2018Date of Patent: March 31, 2020Inventor: Joel Harris
-
Patent number: 10548851Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: GrantFiled: January 23, 2019Date of Patent: February 4, 2020Assignee: InCube Labs, LLCInventors: Mir Imran, Joel Harris
-
Publication number: 20190308779Abstract: A dome-shaped lid reversibly securably sealed to the rim of a container with two opposing drinking ports die-cut in the top wall of a brim mount. A reclosable fold-back hatch cover recessed within the brim mount rotates about a U-shaped hinge between a closed and opened position quickly and reliably. When the hatch cover is rotated to its opened position it creates a hatch opening of sufficient size to access the beverage for the following purposes, including, but not limited to, dunking a confection, letting steam escape to cool a hot beverage, adding condiments, stirring the beverage, or adding and removing toppings such as whipped cream on the surface of the beverage, performed with the lid remaining fixed to the container rim.Type: ApplicationFiled: April 5, 2018Publication date: October 10, 2019Inventor: Joel Harris
-
Publication number: 20190211094Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: ApplicationFiled: January 15, 2019Publication date: July 11, 2019Inventors: Mir IMRAN, Mercedes MORALES, Radhika KORUPOLU, Elaine TO, Joel HARRIS, Mir HASHIM
-
Publication number: 20190151250Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: ApplicationFiled: January 23, 2019Publication date: May 23, 2019Inventors: Mir Imran, Joel Harris
-
Publication number: 20190133937Abstract: Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: November 7, 2018Publication date: May 9, 2019Applicant: Rani Therapeutics, LLCInventors: Mir Imran, Sara Ansaloni, Radhika Korupolu, Joel Harris, Mir Hashim
-
Patent number: 10227403Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: GrantFiled: May 2, 2016Date of Patent: March 12, 2019Assignee: InCube Labs, LLCInventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
-
Patent number: 10220003Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: GrantFiled: March 9, 2017Date of Patent: March 5, 2019Assignee: InCube Labs, LLCInventors: Mir Imran, Joel Harris
-
Publication number: 20190062451Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.Type: ApplicationFiled: September 8, 2016Publication date: February 28, 2019Applicant: Incube Labs, LLCInventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
-
Publication number: 20180353641Abstract: Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.Type: ApplicationFiled: July 13, 2018Publication date: December 13, 2018Applicant: InCube Labs, LLCInventors: Mir Imran, Sanjay Patel, Joel Harris
-
Patent number: 10130514Abstract: Embodiments of the invention provide systems and methods for delivering therapeutic compositions to the inner-ear to treat inner-ear disorders. An embodiment of such a system comprises a sheath for insertion into the auditory canal and a cannula which can be inserted through the sheath. The cannula can include a tip for piercing the tympanic membrane and delivering the composition to an inner-ear tissue surface. The system may also include a therapeutic composition comprising a therapeutic agent and a thixotropic material which allows the composition to be delivered (e.g., by injection) through the cannula in liquid form and transition to gel-form once delivered to the tissue surface. A method for using the system comprises introducing the sheath into the ear, introducing the cannula through the sheath to pierce the tympanic membrane and position the tip adjacent an inner-ear tissue surface; and delivering the composition through the cannula to adhere to the tissue surface.Type: GrantFiled: September 26, 2012Date of Patent: November 20, 2018Assignee: InCube Labs, LLCInventors: Mir Imran, Joel Harris
-
Patent number: 10046085Abstract: Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.Type: GrantFiled: June 1, 2010Date of Patent: August 14, 2018Assignee: InCube Labs, LLCInventors: Mir Imran, Sanjay Patel, Joel Harris
-
Publication number: 20180208651Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-?-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.Type: ApplicationFiled: May 2, 2016Publication date: July 26, 2018Applicant: INCUBE LABS, LLCInventors: Mir Imran, Mercedes Morales, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
-
Publication number: 20180064934Abstract: Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.Type: ApplicationFiled: August 17, 2017Publication date: March 8, 2018Inventors: Mir Imran, Mir Hashim, Glen McLaughlin, Huma Arastu, Rekha Vaidyanathan, Joel Harris, Radhika Korupolu, Andrew Mangogna, Chang Ong, Sanjay Patel, Lu Wang, Timothy Williams
-
Patent number: 9764131Abstract: Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.Type: GrantFiled: June 30, 2015Date of Patent: September 19, 2017Assignee: InCube Labs, LLCInventors: Mir Imran, Mir Hashim, Glen McLaughlin, Huma Arastu, Rekha Vaidyanathan, Joel Harris, Radhika Korupolu, Andrew Mangogna, Chang Ong, Sanjay Patel, Lu Wang, Timothy Williams
-
Publication number: 20170258833Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: ApplicationFiled: March 9, 2017Publication date: September 14, 2017Applicant: Rani Therapeutics, LLCInventors: Mir Imran, Joel Harris
-
Publication number: 20170258732Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.Type: ApplicationFiled: March 9, 2017Publication date: September 14, 2017Applicant: Rani Therapeutics, LLCInventors: Mir Imran, Joel Harris