Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).

Abstract: Example configurations herein include a media player that initiates playback of content (e.g., play back of a movie in a web browser). Based on input from a respective user, the media player receives selections of playback commands (e.g., play, pause, stop, rewind, fast forward, etc.) applied to the content being played back by the media player. Based on the selections, the media player creates a log report. The log report records the selections of the playback commands applied to the content and indicates, for example, a corresponding time when the playback commands were applied. According to one configuration, the media player initiates distribution of the log report to notify a publisher associated with the content which playback commands were selected during playback of the content on the media player.

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).

Abstract: The present invention relates to compounds, pharmaceutical compositions and formulations that have a structure (I). The compounds comprise a heterocyclic ring where W, X, Y, and Z generally and independently are S, N or C with the proviso that at least 2 of these positions in the ring are other than carbon. A pyridine or a substituted pyridine A ring and a phenyl or a substituted phenyl B ring are covalently bonded to the heterocyclic ring. Further provided are methods for treating a metabolic disorder, cell proliferative disease, reducing body weight or increasing thermogenesis during weight loss with the compounds of structure as described or pharmaceutically acceptable salt or stereoisomer thereof or both.

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).

Abstract: The present invention relates to compounds, pharmaceutical compositions and formulations that have a structure (I). The compounds comprise a heterocyclic ring where W, X, Y, and Z generally and independently are S, N or C with the proviso that at least 2 of these positions in the ring are other than carbon. A pyridine or a substituted pyridine A ring and a phenyl or a substituted phenyl B ring are covalently bonded to the heterocyclic ring. Further provided are methods for treating a metabolic disorder, cell proliferative disease, reducing body weight or increasing thermogenesis during weight loss with the compounds of structure as described or pharmaceutically acceptable salt or stereoisomer thereof or both.

Abstract: A data format provides a mechanism to dynamically change the appearance of an application. During operation, the application obtains streaming feed data for presentation to a user. The feed data may be formatted according to a Really Simple Syndication (RSS) data format. The application detects, within the feed data, branding extensions that identify branding content to be displayed concurrently with channel data and content items when a user selects a channel defined by the feed data. The application detects a user selection of the channel defined by the feed data, and in response, references the branding extensions to obtain and display the branding content within a display region of the application that is separate from the content presentation region of the application for display of content items defined within the feed data.

Abstract: Methods and apparatus provide for a region brander configured to uniformly apply branding (i.e graphical modifications) upon both content data and application data to effectuate a seamless branding of an entire region of a graphical user interface (GUI). The region brander defines a hierarchy relationship between content and a branding extension (i.e. embedded modification information) with respect to a region in a Graphical User Interface (GUI). The region brander further defines a master region in the GUI to apply the hierarchy relationship to display the content and the branding extension in the master region. A slave region in the GUI can also be defined to apply the hierarchy relationship in order to: (i) display, in the slave region, the branding extensions related to content selected in the master region, and (ii) display episodic content related to content selected in the master region.

Abstract: Methods and apparatus provide for a region brander configured to uniformly apply branding (i.e graphical modifications) upon both content data and application data to effectuate a seamless branding of an entire region of a graphical user interface (GUI). The region brander defines a hierarchy relationship between content and a branding extension (i.e. embedded modification information) with respect to a region in a Graphical User Interface (GUI). The region brander further defines a master region in the GUI to apply the hierarchy relationship to display the content and the branding extension in the master region. A slave region in the GUI can also be defined to apply the hierarchy relationship in order to: (i) display, in the slave region, the branding extensions related to content selected in the master region, and (ii) display episodic content related to content selected in the master region.

Abstract: Example configurations herein include a media player that initiates playback of content (e.g., play back of a movie in a web browser). Based on input from a respective user, the media player receives selections of playback commands (e.g., play, pause, stop, rewind, fast forward, etc.) applied to the content being played back by the media player. Based on the selections, the media player creates a log report. The log report records the selections of the playback commands applied to the content and indicates, for example, a corresponding time when the playback commands were applied. According to one configuration, the media player initiates distribution of the log report to notify a publisher associated with the content which playback commands were selected during playback of the content on the media player.

Abstract: Example configurations herein include a media player that initiates playback of content (e.g., play back of a movie in a web browser). Based on input from a respective user, the media player receives selections of playback commands (e.g., play, pause, stop, rewind, fast forward, etc.) applied to the content being played back by the media player. Based on the selections, the media player creates a log report. The log report records the selections of the playback commands applied to the content and indicates, for example, a corresponding time when the playback commands were applied. According to one configuration, the media player initiates distribution of the log report to notify a publisher associated with the content which playback commands were selected during playback of the content on the media player.

Abstract: Example configurations herein include a media manager associated with a media player that monitors a media feed for available content. Based on monitoring the media feed (e.g., Really Simple Syndication “RSS” feed), the media manager can receive a pointer to a content playback file. According to one configuration, the content playback file specifies retrievable content (e.g., as specified by pointers therein) and includes instructions indicating how to play back the retrievable content. Upon execution of the content playback file, the media player initiates retrieval of the content as specified by pointers in the content playback file. The media player can initiate playback of the retrieved content in accordance with markup language type playback instructions as specified by the content playback file.

Abstract: A data format provides a mechanism to dynamically change the appearance of an application. During operation, the application obtains streaming feed data for presentation to a user. The feed data may be formatted according to a Really Simple Syndication (RSS) data format. The application detects, within the feed data, branding extensions that identify branding content to be displayed concurrently with channel data and content items when a user selects a channel defined by the feed data. The application detects a user selection of the channel defined by the feed data, and in response, references the branding extensions to obtain and display the branding content within a display region of the application that is separate from the content presentation region of the application for display of content items defined within the feed data.

Abstract: A data format provides a mechanism to dynamically change the appearance of an application. During operation, the application obtains streaming feed data for presentation to a user. The feed data may be formatted according to a Really Simple Syndication (RSS) data format. The application detects, within the feed data, branding extensions that identify branding content to be displayed concurrently with channel data and content items when a user selects a channel defined by the feed data. The application detects a user selection of the channel defined by the feed data, and in response, references the branding extensions to obtain and display the branding content within a display region of the application that is separate from the content presentation region of the application for display of content items defined within the feed data.