Patents by Inventor Joel KARPIAK

Joel KARPIAK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTATED PGLB OLIGOSACCHARYLTRANSFERASE ENZYMES
    Publication number: 20220403347
    Abstract: The present disclosure provides mutated PglB oligosaccharyltransferase enzymes that have the ability to efficiently catalyze the transfer of a saccharide from a lipid carrier to an asparagine reissue in a glycosylation motif on a protein. Also provided are polynucleotides encoding the mutated PglB oligosaccharyltransferase enzymes, host cells capable of expressing the engineered PglB oligosaccharyltransferase enzymes, and methods of using the engineered PglB oligosaccharyltransferase enzymes to make N-glycosylated proteins. Also provided are N-glycosylated proteins that are made using the engineered PglB oligosaccharyltransferase enzymes.
    Type: Application
    Filed: August 6, 2020
    Publication date: December 22, 2022
    Inventors: Leigh Anne IHNKEN, Joel KARPIAK, Stefan Jochen KEMMLER, Michael Thomas KOWARIK, Joel MELBY, Anne OLLIS, Julien Laurent QUEBATTE
  • Bisaryl amides as NRF2 activators
    Patent number: 11078216
    Abstract: The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 3, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: James Francis Callahan, Vincent J. Colandrea, Anthony William James Cooper, Nicole Cathleen Goodwin, Chelsea Ariane Huff, Joel Karpiak, Jeffrey K. Kerns, Hong Nie
  • BISARYL AMIDES AS NRF2 ACTIVATORS
    Publication number: 20190330238
    Abstract: The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators.
    Type: Application
    Filed: December 11, 2017
    Publication date: October 31, 2019
    Inventors: James Francis CALLAHAN, Vincent J. COLANDREA, Anthony William James COOPER, Nicole Cathleen GOODWIN, Chelsea Ariane HUFF, Joel KARPIAK, Jeffrey K. KERNS, Hong NIE