Patents by Inventor Joel N. Kline

Joel N. Kline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating pulmonary diseases and disorders by modulating calcium/calmodulin dependent protein kinase II activity
    Patent number: 8440656
    Abstract: Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 14, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Mark E. Anderson, Isabella M. Grumbach, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Patent number: 8258106
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: September 4, 2012
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman, Alfred D. Steinberg
  • Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity
    Publication number: 20110152172
    Abstract: Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.
    Type: Application
    Filed: June 22, 2010
    Publication date: June 23, 2011
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Mark E. Anderson, Isabella M. Grumbach, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Patent number: 7935675
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: May 3, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Methods of using immunostimulatory nucleic acid molecules to treat allergic conditions
    Patent number: 7888327
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: February 15, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Publication number: 20100125101
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: March 25, 2009
    Publication date: May 20, 2010
    Inventors: Arthur M. Krieg, Joel N. Kline
  • IMMUNOSTIMULATORY NUCLEIC ACID MOLECULES
    Publication number: 20090202575
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: October 9, 2008
    Publication date: August 13, 2009
    Applicants: University of Iowa Research Foundation, The US, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman
  • Immunostimulatory nucleic acid molecules
    Patent number: 7524828
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: April 28, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Patent number: 7517861
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: April 14, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Patent number: 7402572
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: July 22, 2008
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Method for inhibiting inflammatory responses
    Patent number: 6638518
    Abstract: The present invention provides methods for treating at least one symptom of an inflammatory response in a mammal by administering a polypeptide to the mammal. The polypeptide can be a microbial polypeptide, or a Mycobacterial polypeptide. The present invention further provides an inflammation reaction inhibiting composition that includes a microbial polypeptide and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 28, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Timothy L. Ratliff, Joel N. Kline
  • Immunostimulatory nucleic acid molecules
    Patent number: 6239116
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: May 29, 2001
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline