Abstract: The present invention relates to a tank holder system that does not substantially restrict alternative uses of truck bed space when the tank holder system is not in use. The tank holder system includes a tank holder and a base, which receives the tank holder and secures the tank holder during transportation. The tank holder includes an arcuate cradle formed to accept cylindrically-shaped tanks and fasteners that secure such tanks in the arcuate cradle. When the tank holder is not in use, it can be removed from the base. The base remains attached to the truck bed. This allows the space in the truck bed to be used for alternative purposes when the tank holder is disengaged from the base, while allowing the tank holder to be quickly and easily re-engaged to the base.