Patents by Inventor Joel P. Schneidér
Joel P. Schneidér has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200197307Abstract: The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon, liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence. CL is a cross-linking motif and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, Q wherein the cell may be in vitro, ex vi, or in vivo.Type: ApplicationFiled: July 30, 2018Publication date: June 25, 2020Inventors: Joel P. Schneider, Scott H. Medina
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Patent number: 8834926Abstract: A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl.Type: GrantFiled: July 31, 2009Date of Patent: September 16, 2014Assignee: University of DelawareInventors: Joel P. Schneidér, Monica C. Branco, Darrin J. Pochan, Norman J. Wagner
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Patent number: 8426559Abstract: A peptide comprising the sequence VKVKVRVKVDPPTKVKVRVKV-NH2 forms a hydrogel which has the ability to shear-thin and recover. The hydrogel, both before and after shear-thinning, is capable of killing bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).Type: GrantFiled: March 24, 2010Date of Patent: April 23, 2013Assignee: University of DelawareInventors: Daphne A. Salick, Darrin J. Pochan, Joel P. Schneider
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Patent number: 8221773Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.Type: GrantFiled: December 22, 2010Date of Patent: July 17, 2012Assignee: University of DelawareInventors: Joel P. Schneider, Darrin J. Pochan
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Publication number: 20110171304Abstract: A peptide comprising the sequence VKVKVRVKVDPPTKVKVRVKV-NH2 forms a hydrogel which has the ability to shear-thin and recover. The hydrogel, both before and after shear-thinning, is capable of killing bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).Type: ApplicationFiled: March 24, 2010Publication date: July 14, 2011Applicant: University of DelawareInventors: Daphne A. Salick, Darrin J. Pochan, Joel P. Schneider
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Publication number: 20110165200Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.Type: ApplicationFiled: December 22, 2010Publication date: July 7, 2011Applicant: University of DelawareInventors: Joel P. Schneider, Daniel J. Pochan
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Publication number: 20110052692Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.Type: ApplicationFiled: July 30, 2010Publication date: March 3, 2011Applicant: University of DelawareInventors: Bulent Ozbas, Juliana Kretsinger, Lisa A. Butterick, Karthikan Rajagopal, Darrin J. Pochan, Joel P. Schneider
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Patent number: 7884185Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.Type: GrantFiled: July 28, 2004Date of Patent: February 8, 2011Assignee: University of DelawareInventors: Joel P. Schneider, Darrin J. Pochan
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Patent number: 7858585Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.Type: GrantFiled: November 14, 2006Date of Patent: December 28, 2010Assignee: University of DelawareInventors: Bulent Ozbas, Juliana Kretsinger, Lisa Ann Butterick, Karthikan Rajagopal, Darrin J. Pochan, Joel P. Schneider
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Publication number: 20100034881Abstract: A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl.Type: ApplicationFiled: July 31, 2009Publication date: February 11, 2010Applicant: The University of DelawareInventors: Joel P. Schneider, Monica C. Branco, Darrin J. Pochan, Norman J. Wagner
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Publication number: 20090238788Abstract: A method for delivering ?-sheet peptide hydrogels to a target surface by shear-thinning and spraying the peptide hydrogel on the surface is provided. The ?-sheet peptide hydrogels can be applied over a range of thicknesses and can cover broad surface areas. The ?-sheet peptide hydrogels may also include a therapeutic agent.Type: ApplicationFiled: March 19, 2009Publication date: September 24, 2009Applicant: University of DelawareInventors: Lisa A. Butterick, Darrin J. Pochan, Joel P. Schneider