Patents by Inventor Joel Portnoff

Joel Portnoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of cancers by inhalation of stable platinum-containing formulations
    Publication number: 20050107287
    Abstract: Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.
    Type: Application
    Filed: September 20, 2004
    Publication date: May 19, 2005
    Inventors: Frank Pilkiewicz, Joel Portnoff, Lawrence Boni, Jin Lee
  • Low toxicity drug-lipid systems
    Publication number: 20020119170
    Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
    Type: Application
    Filed: April 26, 2002
    Publication date: August 29, 2002
    Inventors: Andrew S. Janoff, Thomas D. Madden, Pieter R. Cullis, John J. Kearns, Anthony G. Durning, Lawrence Boni, Robert P. Lenk, Robert Klimchak, Joel Portnoff
  • Method for size separation of particles
    Patent number: 5948441
    Abstract: Tangential flow filtration is used in the size separation of particles, such as liposomes and lipid particles. These particles may be passed through a tangential flow filtration device of any pore size desired. Tangential flow filter systems of various pore sizes may be used sequentially to obtain particles such as lipid particles or liposomes having a defined size range.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: September 7, 1999
    Assignee: The Liposome Company, Inc.
    Inventors: Robert P. Lenk, Anthony G. Durning, Robert J. Klimchak, Joel Portnoff, Michelle L. Tomsho
  • Taxane-containing phosphatidylcholine liposomes
    Patent number: 5683715
    Abstract: Provided herein are liposomal taxane formulations where the liposomal lipid is a phosphatidylcholine; these formulations are useful for treating animals afflicted with cancers.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 4, 1997
    Assignee: The Liposome Company, Inc.
    Inventors: Lawrence Boni, Joel Portnoff
  • Low toxicity drug-lipid systems
    Patent number: 5616334
    Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: April 1, 1997
    Assignee: The Liposome Company, Inc.
    Inventors: Andrew S. Janoff, Lawrence Boni, Thomas D. Madden, Pieter R. Cullis, Robert P. Lenk, John J. Kearns, Anthony G. Durning, Robert Klimchak, Joel Portnoff
  • Method of producing liposomes
    Patent number: 5540936
    Abstract: This invention provides a process for the production of liposomes by combining an organic phase and an aqueous at a volume ratio of less than 3:1; the process can be conducted under conditions which obtain a single-modal population distribution of liposomes encompassing a pre-selected mean particle size. A novel intermediate product obtained during the process, which can itself be used for the topical delivery of a bioactive agent, is also provided.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: July 30, 1996
    Assignee: The Liposome Company, Inc.
    Inventors: Royden M. Coe, Laura Edgerly-Pflug, Lawrence Boni, Joel Portnoff, Sharma R. Minchey