Patents by Inventor Joel R. Jacobson

Joel R. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphs of 1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine Ethane-Sulfonate
    Publication number: 20090124652
    Abstract: The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.
    Type: Application
    Filed: December 28, 2005
    Publication date: May 14, 2009
    Inventors: David Ach, Hughes Martin, Anna Van, Joel R. Jacobson, Junshi Y. Wu, Kyle J. Lindstrom, Tai T. Tran, Myles L. Brostrom, Michael J. Rice, Raymond D. Skwierczynski
  • 1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Ethanesulfonate and 1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Methanesulfonate
    Publication number: 20080188513
    Abstract: This invention provides methanesulfonate and ethanesulfonate salts of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine, pharmaceutical compositions containing the salts, methods of making, and methods of use.
    Type: Application
    Filed: December 28, 2005
    Publication date: August 7, 2008
    Inventors: Raymond D. Skwierczynski, Myles L. Brostrom, Tai T. Tran, Joel R. Jacobson
  • Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxy lic acid
    Patent number: 4301288
    Abstract: An improved process for preparing the antimicrobial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50.degree. and 60.degree. C. In the second step, the product of the first step is slowly added to a refluxing solvent which forms a binary azeotrope with water and has a boiling point between 90.degree. and 120.degree. C. to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydroquinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: November 17, 1981
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Charles M. Leir, Kirk G. Hedberg, Joel R. Jacobson