Patents by Inventor Joel R. L. Ehrenkranz
Joel R. L. Ehrenkranz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230095831Abstract: Enzyme-based diagnostic testing systems for detecting and quantifying at least one of the activity level or the concentration of an enzyme or a biochemical analyte in a biological sample. Such enzyme-based diagnostic testing systems can provide rapid, accurate, affordable laboratory-quality testing at the point of care. An enzyme-based diagnostic testing system may include a lateral-flow chromatographic assay cassette that is configured for assaying an amount or activity of an enzyme in a sample or for enzymatically determining the concentration of an enzyme substrate in a sample. Additionally, the enzyme-based diagnostic testing systems may include testing devices (e.g., a smartphone or a similar remote computing device) having data collection and data analysis capabilities. Such testing devices may also include automated data reporting and decision support.Type: ApplicationFiled: November 15, 2022Publication date: March 30, 2023Inventor: Joel R.L. Ehrenkranz
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Patent number: 10871486Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: GrantFiled: August 21, 2018Date of Patent: December 22, 2020Assignee: i-calQ, LLCInventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Patent number: 10859568Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: GrantFiled: August 21, 2018Date of Patent: December 8, 2020Assignee: i-CAlQ, LLCInventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Publication number: 20200340988Abstract: Enzyme-based diagnostic testing systems for detecting and quantifying at least one of the activity level or the concentration of an enzyme or a biochemical analyte in a biological sample. Such enzyme-based diagnostic testing systems can provide rapid, accurate, affordable laboratory-quality testing at the point of care. An enzyme-based diagnostic testing system may include a lateral-flow chromatographic assay cassette that is configured for assaying an amount or activity of an enzyme in a sample or for enzymatically determining the concentration of an enzyme substrate in a sample. Additionally, the enzyme-based diagnostic testing systems may include testing devices (e.g., a smartphone or a similar remote computing device) having data collection and data analysis capabilities. Such testing devices may also include automated data reporting and decision support.Type: ApplicationFiled: April 26, 2019Publication date: October 29, 2020Inventor: Joel R.L. Ehrenkranz
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Patent number: 10613082Abstract: Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.Type: GrantFiled: November 20, 2018Date of Patent: April 7, 2020Assignee: i-calQ, LLCInventor: Joel R. L. Ehrenkranz
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Patent number: 10498936Abstract: Devices and methods for performing a point of care diagnostic test. In one embodiment, such a device may be adaptable to essentially any handheld digital imaging device. Such a device may include a sample holder for positioning an assay device in relation to the digital imaging device and an expandable/contractible member having the sample holder slidably coupled thereto. The expandable/contractible member is configured for removably attaching the testing device the digital imaging device and for positioning the sample holder in relation to an image capture means of the digital imaging device. In one embodiment, such devices may include a second slot configured for receiving one or more of a second assay cassette, an assay device, assay cassettes of various sizes, a printed circuit board, and the like.Type: GrantFiled: April 21, 2015Date of Patent: December 3, 2019Assignee: i-CalQ, LLCInventor: Joel R. L. Ehrenkranz
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Patent number: 10352920Abstract: Methods for monitoring and adjusting a physiological state of a subject. The methods include (1) providing a subject having one or more physiological parameters defined by one or more biometrics, (2) monitoring a selected biometric analyte associated with a selected biometric to define a state of the selected biometric, (3) based on the results of the monitoring, adjusting the state of the selected biometric by administering to the subject a supplement selected to affect the state of the selected biometric.Type: GrantFiled: December 20, 2013Date of Patent: July 16, 2019Assignee: i-calQ, LLCInventor: Joel R. L. Ehrenkranz
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Publication number: 20190086400Abstract: Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.Type: ApplicationFiled: November 20, 2018Publication date: March 21, 2019Inventor: Joel R. L. Ehrenkranz
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Publication number: 20180356406Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Inventors: Joel R.L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Publication number: 20180356407Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Inventors: Joel R.L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Patent number: 10132802Abstract: Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.Type: GrantFiled: April 12, 2013Date of Patent: November 20, 2018Assignee: I-CALQ, LLCInventor: Joel R. L. Ehrenkranz
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Patent number: 10054584Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: GrantFiled: November 1, 2013Date of Patent: August 21, 2018Assignee: I-CALQ, LLCInventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Patent number: 9322767Abstract: Devices and methods for performing a point of care blood, cell, and/or pathogen count or a similar blood test. Disclosed herein are systems that can be used to provide rapid, accurate, affordable laboratory-quality testing at the point of care. The systems described herein are capable of imaging and counting individual cells in a prepared cell sample (e.g., a peripheral blood smear or a blood sample prepared in a microfluidic device) or another prepared cell-containing sample without the need for a microscope or other expensive and cumbersome optics. The systems described herein are designed to eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such systems may include automated data reporting and decision support.Type: GrantFiled: April 12, 2013Date of Patent: April 26, 2016Assignee: i-calQ, LLCInventor: Joel R. L. Ehrenkranz
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Publication number: 20150338387Abstract: Methods for monitoring and adjusting a physiological state of a subject. The methods include (1) providing a subject having one or more physiological parameters defined by one or more biometrics, (2) monitoring a selected biometric analyte associated with a selected biometric to define a state of the selected biometric, (3) based on the results of the monitoring, adjusting the state of the selected biometric by administering to the subject a supplement selected to affect the state of the selected biometric.Type: ApplicationFiled: December 20, 2013Publication date: November 26, 2015Inventor: Joel R. L. EHRENKRANZ
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Publication number: 20150304555Abstract: Devices and methods for performing a point of care diagnostic test. In one embodiment, such a device may be adaptable to essentially any handheld digital imaging device. Such a device may include a sample holder for positioning an assay device in relation to the digital imaging device and an expandable/contractible member having the sample holder slidably coupled thereto. The expandable/contractible member is configured for removably attaching the testing device the digital imaging device and for positioning the sample holder in relation to an image capture means of the digital imaging device. In one embodiment, such devices may include a second slot configured for receiving one or more of a second assay cassette, an assay device, assay cassettes of various sizes, a printed circuit board, and the like.Type: ApplicationFiled: April 21, 2015Publication date: October 22, 2015Inventor: JOEL R. L. EHRENKRANZ
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Patent number: 8889424Abstract: A device and method for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample (e.g., a body fluid). A device may include an immunoassay apparatus and a holder with an adjustable variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device so as to optimize the angle of incidence and angle of radiation to optimize an elastic light scattering signal from the immunoassay apparatus. The elastic light scattering signal may be used to quantify the amount of the analyte(s) of interest present in the sample. The device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering.Type: GrantFiled: September 12, 2012Date of Patent: November 18, 2014Inventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Publication number: 20140213468Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: ApplicationFiled: November 1, 2013Publication date: July 31, 2014Inventors: Joel R.L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Publication number: 20140170768Abstract: Methods for monitoring pituitary function and for distinguishing Cushing's disease from Cushing's syndrome. The methods includes (1) providing a subject, (2) administering to the subject a daily dosage of a glucocorticoid antagonist, (3) monitoring adrenocorticotropic hormone (“ACTH”) and/or cortisol levels in the subject. Subjects having normal pituitary function typically show an increase in ACTH and/or cortisol levels following glucocorticoid antagonist therapy, while subjects having abnormal pituitary function will typically show no significant change in ACTH or cortisol following glucocorticoid antagonist therapy. Similarly, subjects having Cushing's disease show a significant rise in ACTH and cortisol levels following glucocorticoid antagonist therapy, while, in contrast, subjects having Cushing's syndrome show no significant change in ACTH and/or cortisol following glucocorticoid antagonist therapy.Type: ApplicationFiled: December 13, 2013Publication date: June 19, 2014Inventor: Joel R. L. Ehrenkranz
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Publication number: 20140018426Abstract: Food or beverage compositions fortified with thyronines and/or thyronamines, processes for increasing T2, T1AM, and/or T0AM in a subject by administering a food or beverage composition that is fortified with at least one thyronine and/or thyronamine compound, and processes for promoting a healthy state by administering a food or beverage composition to a subject that is fortified with at least one thyronine and/or thyronamine compound. Increased levels of T2, T1AM, and/or T0AM in a subject can be associated with at least one of healthy cholesterol levels, healthy triglyceride levels, healthy blood sugar levels, cardiovascular health, healthy sleep patterns, healthy mood, healthy skin, healthy nails, or healthy endocrine function and/or a number of other markers of associated with general health and well-being.Type: ApplicationFiled: September 12, 2013Publication date: January 16, 2014Applicant: T*Amine, LLCInventors: Joel R.L. Ehrenkranz, Thomas S. Scanlan
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Publication number: 20130273524Abstract: Devices and methods for performing a point of care blood, cell, and/or pathogen count or a similar blood test. Disclosed herein are systems that can be used to provide rapid, accurate, affordable laboratory-quality testing at the point of care. The systems described herein are capable of imaging and counting individual cells in a prepared cell sample (e.g., a peripheral blood smear or a blood sample prepared in a microfluidic device) or another prepared cell-containing sample without the need for a microscope or other expensive and cumbersome optics. The systems described herein are designed to eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such systems may include automated data reporting and decision support.Type: ApplicationFiled: April 12, 2013Publication date: October 17, 2013Inventor: Joel R. L. Ehrenkranz