Abstract: An apparatus for simulating the effect of a living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form, including a beaker-shaped container for accommodating a test medium and the pharmaceutical dosage form and an agitating device for agitating the test medium, which agitating device can be moved periodically in a reciprocating movement into and back out of the container, wherein the agitating device includes a piston-shaped head portion arranged on a piston rod, which head portion is provided with through-openings for the test medium and the distance of the piston-shaped head portion from the container floor can be altered periodically in accordance with the periodic reciprocating movement of the agitating device, wherein, the piston rod is suspended from a gallows-shaped boom or the piston rod passes through a bore in the gallows-shaped boom in such a manner that downward movement of the piston-shaped head portion ar

Abstract: The invention relates to a monolith transdermal therapeutic system for the delivery of permeable drugs, especially formoterol, in the form of a matrix system comprising three layers: a) a backing layer which is impermeable to the components of the adhesive layer b),b) an adhesive layer capable of releasing the drug and consisting of a permeable polymeric material which is compatible with the skin and contains at least one drug which is capable of permeation across the skin, a combination of eucalyptol having a purity of at least 70% with an additional flux enhancer and further optional pharmaceutical excipients, andc) a protective release liner which can be peeled from the adhesive contact layer b).

Abstract: The invention relates to a transdermal therapeutic system in the form of a multilayer plaster for the administration of active substances which are able to permeate, in the form of a matrix system containing at least three layers:(a) a covering layer which is impermeable for the constituents of the reservoir b);(b) a reservoir layer which is able to deliver active substance and which consists of optionally crosslinked block copolymer based on styrene, alkadienes and optionally alkenes mixed with adhesive polymers and is optionally provided with an additional adhesive membrane layer and contains at least one active substance capable of skin permeation, at least one agent promoting the skin permeability of active substances and optionally further pharmaceutical auxiliaries, and(c) a protective film which can be pulled off the reservoir layer.

Abstract: The invention relates to a covered, solid retard form which in the case of oral administration remains in the stomach during periodic emptying and ensures continuous release. This dosage form contains the following components:(a) at least one component that expands on contact with body fluid and that contains a physiologically active substance or a combination of such substances,(b) at least one permeable hydrophilic membrane which surrounds component (a) and which is expansible at the site of use, and optionally(c) a covering which surrounds components (a) and membrance (b) and which disintegrates without delay under the action of a body fluid at the site of use.

Abstract: The invention relates to a pharmaceutical plaster that adheres to the mucosa, consisting of two discrete layers that adhere well to one another, which may contain pharmaceutical active ingredients suitable for topical application or for systemic treatment. It is distinguished by outstanding long-lasting adhesion to the mucosa and is very pleasant in use, especially in the mouth as an oral plaster.

Abstract: Use of succinosuccinic acid diesters of the formula ##STR1## in which R is an alkyl, alkenyl or cycloalkyl having 4 to 24 C atoms, either dissolved in a water-immiscible organic solvent, or at elevated temperature in the form of their melts, as cation-selective liquid membranes.

Abstract: Use of succinosuccinic acid diesters of the formula ##STR1## in which R is an alkyl, alkenyl or cycloalkyl having 4 to 24 C atoms, either dissolved in a water-immiscible organic solvent, or at elevated temperature in the form of their melts, as cation-selective liquid membranes.

Abstract: Novel photo-crosslinkable polymers are obtained by reacting, and polycondensing, bis-(hydroxyalkyl) succinylosuccinates or bis-(hydroxycycloalkyl) succinylosuccinates with maleic anhydride, maleinimid or N-methylmaleinimid in a molar ratio of 1:1 to 1:2. The novel polymers are useful as photoresists, and the films consisting of the crosslinked polymers are useful as solvent-resistant membranes for reverse osmosis.

Abstract: Polymers from the group consisting of cellulose and its ester and ether derivatives, of polyvinyl alcohol and its ester derivatives, copolymers with vinyl esters and homopolymers and copolymers of acrylates and methacrylates are modified with monofunctional or difunctional cyclic .beta.-ketonic acids or their esters, in particular with succinylsuccinic acid or its ester derivatives. The modified polymers are particularly suitable for obtaining semi-permeable membranes for osmotic separation methods.

Abstract: Polymers from the group consisting of cellulose and its ester and ether derivatives, of polyvinyl alcohol and its ester derivatives, polymers with vinyl esters and homopolymers and copolymers of acrylates and methacrylates are modified with monofunctional or difunctional cyclic .beta.-ketonic acids or their esters, in particular with succinylsuccinic acid or its ester derivatives. The modified polymers are particularly suitable for obtaining semi-permeable membranes for osmotic separation methods.

Abstract: The invention provides nickel and cobalt chelate complexes of a nickel or cobalt salt and a succinosuccinate of the formula I ##STR1## wherein R represents a substituted or unsubstituted hydrocarbon radical of aliphatic or aromatic character. These complexes are excellent adhesion promoters for vulcanized rubber on metal surfaces.

Abstract: Compounds of formula I ##SPC1##wherein R denotes hydrogen or an aliphatic or aromatic radical. These compounds are prepared by irradiation of succinylsuccinic acid or diesters thereof, in the crystalline state, with UV light rays or with .gamma.-radiation.