Abstract: A method for making an audio speaker cover using at least some of the following steps, not necessarily in the sequence listed: evolving a CAD first stage model of an audio speaker cover with an array of apertures; determining a desired blank workpiece manufacturing configuration by electing to process a single blank workpiece or an assembly of stacked blank workpieces; affixing the single blank workpiece or stacked blank workpieces in relation to a CNC machine; addressing one or more of the stacks simultaneously or sequentially to create apertures in the audio speaker covers with parallel walls and square shoulders to provide strength while minimizing losses in sound transmission, the apertures and intervening lands providing a visually attractive appearance to an observer.

Abstract: A control system for a construction machine is disclosed. The control system may comprise a controller configured to: receive work parameters associated with working of the worksite surface by a surface-working member; generate an edge-to-edge work plan of the worksite surface, the edge-to-edge work plan comprising a plurality of paths each having a center-line-of-travel, wherein one of the plurality of paths includes a first outer edge defined by a first boundary side and another includes a second outer edge defined by a second boundary side; and activate the construction machine to traverse the center-line-of travel of each of the plurality of paths. The plurality of paths may comprise a first path and a second path that includes a second path overlap-section that overlaps the first path, wherein a width of the second path overlap-section varies along a length of the second path.

Abstract: This invention is a safe and effective method to treat chronic pain with the oral administration of procaine as a non-selective voltage sodium channel (VGSC) blocker. The dose of oral procaine has been estimated based upon the pharmacokinetics required to produce action potential inhibition in neurons of dorsal root ganglia. Intraneural ion trapping effects and low CSF pseudocholinesterase will increase the concentration of charged procaine within Nav 1.8 channels. The co-administration of benzodiazepines will increase the therapeutic ratio of procaine mitigating central nervous system toxicity. A dibucaine number is required prior to initiation of therapy. Side effects have hindered development of selective VGSC blockers. Modification of oral procaine administration with over 100 clinical practice years of known side effects may meet this unmet need.

Abstract: This document relates to an optical device that uses adaptive optics as part of an optical system. The adaptive optics can be used to correct light rays that correspond to a portion of an eye box based on information received from an eye-tracking unit, and can also correct for aberrations in the optics in the optical device. The adaptive optics include corrective elements that can be modified using modifying elements to correct the angle of light rays, such that rays associated with a specific pupil position and gaze direction of a user's eye can be made parallel and ensure a high quality image is viewed by the user.

Abstract: The present disclosure describes near-eye display systems including an array of projectors and a one-dimensional exit pupil expander. The array of projectors can be arranged along a first dimension and can output image light towards an input coupler within a waveguide that provides one-dimensional exit pupil expansion. In some implementations, arrays of monochromatic projectors are implemented and arranged in offset columns. The input coupler in-couples the image light from the array of projectors into a TIR path within the waveguide. Different optical elements, including diffractive and reflective optics, may be implemented as the input coupler. The image light travels within the waveguide until it interacts with an output coupler. Upon interaction with the output coupler, the image light is expanded in a second dimension transverse to the first dimension and is coupled out of the waveguide.

Abstract: Parkinson's disease is characterized by degeneration of highly metabolic dopaminergic neurons which produce clinical signs to include tremor, rigidity, and glabellar reflex. There are few objective, inexpensive, sensitive, and specific tests for early diagnosis of Parkinson's disease. In this invention, patients who manifest early objective signs of possible Parkinson's disease are pretreated with a supplement to increase central nervous system NAD+, and then subsequently administered a sodium L-lactate infusion after which the signs of early Parkinson's disease are recorded. Remission of the early signs of Parkinson's disease is diagnostic for Parkinson's disease. A clinical trial is suggested.

Abstract: A device includes a frame configured to be supported in front of a user eye. The frame has a first side facing the user eye and a second side opposite the first side and facing an environment. A light emitting diode is supported by the frame to emit light. The light emitting diode is obscured by an opaque material from an observer in front of the user in the environment. A light deflector is supported by the frame to direct the emitted light from the light emitting diode towards the user eye.

Abstract: Examples are disclosed that relate to using an array of hot mirrors in an eye-imaging system. One example provides a head-mounted display system, comprising a frame, an eye-imaging camera supported on the frame, a switchable hot mirror array comprising a plurality of switchable hot mirrors configured to direct light reflecting from an eye toward the eye-imaging camera, and a controller configured to control switching of a reflectivity of each of the plurality of switchable hot mirrors.

Abstract: Aspects of the subject disclosure are directed towards safely projecting a diffracted light pattern, such as in an infrared laser-based projection/illumination system. Non-diffracted (zero-order) light is refracted once to diffuse (defocus) the non-diffracted light to an eye safe level. Diffracted (non-zero-order) light is aberrated twice, e.g., once as part of diffraction by a diffracting optical element encoded with a Fresnel lens (which does not aberrate the non-diffracted light), and another time to cancel out the other aberration; the two aberrations may occur in either order. Various alternatives include upstream and downstream positioning of the diffracting optical element relative to a refractive optical element, and/or refraction via positive and negative lenses.

Abstract: This invention describes the potential benefits of chronic oral administration of triethyl citrate (TEC) for the treatment of Alzheimer's disease and atherosclerosis. Evidence is presented that TEC crosses the blood brain barrier via passive diffusion, and the pharmacologic properties of TEC are distinct from administration of citrate salts. Further clinical trials in animal and human subjects is encouraged.

Abstract: An illumination system for non-emissive polarization-sensitive microdisplays such as LCoS is implemented in a waveguide that guides illumination light from an unpolarized source to the microdisplay while simultaneously recycling light of the wrong polarization for the microdisplay to improve illumination efficiency. Polarization recycling may be performed at one or more of an input coupler that in-couples illumination light to the waveguide, the waveguide itself, or an output coupler that out-couples the illumination light from the waveguide to the microdisplay.

Abstract: Examples are disclosed that relate to using an array of hot mirrors in an eye-imaging system. One example provides a head-mounted display system, comprising a frame, an eye-imaging camera supported on the frame, a switchable hot mirror array comprising a plurality of switchable hot mirrors configured to direct light reflecting from an eye toward the eye-imaging camera, and a controller configured to control switching of a reflectivity of each of the plurality of switchable hot mirrors.

Abstract: Slanted surface relief gratings for use in an optical display system in an HMD device are replicated in a manufacturing process that utilizes non-contact optical proximity recording into a specialized photo-sensitive resin that is disposed over a waveguide substrate. The recording process comprises selective resin exposure to ultraviolet light through a mask to spatially record grating structures by interferential exposure and polymerization. Subsequent resin development evacuates unexposed resin down to the waveguide substrate to remove flat surfaces, referred to as a bias layer, that remain in the grating trenches after exposure. The resin development reduces Fresnel reflections that could otherwise be induced at the media interface between the bias layer and the waveguide substrate. Fresnel reflections may cause a loss of diffraction efficiency and thereby reduce the field of view that may be guided by the SRGs in the optical display system.

Abstract: The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the palisades of Vogt from the data represented therein, and display the data in real-time or as a part of a medical record for ongoing.

Abstract: One disclosed example provides a near-eye display device. The near-eye display device comprises an eye tracking system configured to determine a position of an eye of a user relative to the near-eye display device, and a waveguide including at least an input coupler and an output coupler, the output coupler including a plurality of zones, each zone activatable via a dynamically controllable output coupling element of the zone. The near-eye display device further comprises an image source configured to output image light to the input coupler, and a controller configured to selectively activate one or more zones of the output coupler based at least on the position of the eye.

Abstract: Examples are disclosed that relate to a compact optical systems comprising SLMs. One example provides a projection system comprising an illumination stage including a light emitting diode (LED) array. The LED array comprises a plurality of red LEDs, a plurality of green LEDs, and a plurality of blue LEDs. The illumination stage further comprises an illumination stage optical system configured to control an angular extent of light emitted by the LED array and homogenize the light emitted by the LED array. The projection system further comprises an image forming stage configured to form an image from light output by the illumination stage, the image forming stage comprising a spatial light modulator (SLM) configured to spatially modulate the light output by the illumination stage to form an image, and one or more projection optics configured to project the image formed by the spatial light modulator.

Abstract: This invention describes an affordable, renewable, sustainable (ARS) system to produce electricity, comprising a zinc air fuel cell (ZAFC) and photovoltaic cell. This ZAFC produces electricity operating in the pH range of 6.5-8.5 such that the primary waste species in the electrolyte are zinc cations of Zn+2 and ZnOH+. These cations are reduced by electrons from photovoltaic cells, and this ZAFC is easily rechargeable with a photovoltaic cell, and it can be overcharged. Also the electrolyte can be separated from the cell, and plating with photo reduction of zinc occurs rapidly on graphite, copper, or zinc cathodes. The efficiency of the ZAFC is approximately 58%, plus the added efficiency of reclaimed reduced zinc cations to zinc, either through recharging or plating. The electrolyte can be seawater or saline. The raw materials for this ZAFC are sufficiently available such that this system could provide ARS electricity.

Abstract: Hyperscanning, the simultaneous measurement of brain activity among dyads or groups, has shown synchrony measured by fMRI, EEG, MEG, and fNIRS. This synchrony is evident during cooperative decision-making, but the underlying mechanism has not been elucidated. At minimum, in order for synchrony to occur, systems must oscillate and share information. Through the skin effect, changing magnetic fields permeate the human central nervous system, can share information from dyads and groups, and can synchronize oscillating oxygen reduction reactions (ORR) in the mitochondria. In vitro evidence has shown that ORR can be influenced ?-m tesla, extremely low frequency magnetic fields without producing thermal or ionization effects. Ascertaining the unique characteristics of such magnetic fields that can produce interbrain synchrony is a daunting task; however, this discovery could benefit impasse conflict negotiations.