Patents by Inventor Joel Voldman
Joel Voldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230321659Abstract: Microfluidic chips, systems, and methods of making and using thereof are described. The microfluid chip includes a disc-shaped transparent layer containing a plurality of cell traps, pillars, and filers, and a support layer attached thereto. The microfluid chip has at least one inlet port in center of the transparent layer for receiving a sample of liquid and cells, and optionally a plastic cover. The microfluid chip can be designed to be suitable for the forces used for cell pairing/fusion in stationary and spinning format, or suitable for a particular cell fusion method such chemical and electrical methods. The microfluid chip is particularly suited for fusing dendritic cells and tumor cells for immunotherapy, or for generating hybridoma.Type: ApplicationFiled: February 9, 2023Publication date: October 12, 2023Inventors: Mohammadmahdi Aeinehvand, Sergio Omar Martinez-Chapa, Joel Voldman
-
Publication number: 20230264192Abstract: Microfluidic chips containing electrochemical biosensors are described. The electrochemical biosensors include a flow layer intersected by valves of a control layer, which control the fluid flow. The flow layer includes two zones, an analyte capture zone for mixing a sample with an analyte capture element, and a detection zone for detecting the analyte. Both zones include a rotary mixer for mixing, and where needed, trapping, washing, and flowing the captured analyte. The captured analyte is detected by the sensing region of the detection zone. The microfluidic chips may be integrated into devices for automated, fast, point-of-care determination of analyte concentration.Type: ApplicationFiled: July 16, 2021Publication date: August 24, 2023Inventors: Dan Wu, Joel Voldman
-
Patent number: 10598166Abstract: Endothelial cells can become susceptible to disease when subjected to disturbed (atheroprone) blood flow patterns, which naturally occur in known locations in human arteries. Atheroprone flow is non-laminar, with low fluid shear stress magnitude and an oscillatory pattern representative in the temporal signature. At a macro-scale, atheroprone flow is multidirectional and chaotic. On the other hand, atheroprotective flow is laminar with high fluid shear stresses that have a specific temporal signature. Therefore, understanding the interplay between the atheroprotective and atheroprone hemodynamics and endothelial function is important. The invention relates, in some embodiments, to microfluidic devices and methods that dynamically apply controlled and physiologically relevant spatio-temporal atheroprone and atheroprotective flow signatures.Type: GrantFiled: September 9, 2016Date of Patent: March 24, 2020Assignee: Massachusetts Institute of TechnologyInventors: Sarvesh Varma, Joel Voldman
-
Publication number: 20190046986Abstract: A particle separation device can include a fiber microfludic structure.Type: ApplicationFiled: October 5, 2018Publication date: February 14, 2019Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Rodger YUAN, Jaemyon LEE, Joel VOLDMAN, Yoel FINK, Hao-wei SU
-
Patent number: 10098581Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.Type: GrantFiled: January 16, 2015Date of Patent: October 16, 2018Assignee: Massachusetts Institute of TechnologyInventors: Joel Voldman, Hao-Wei Su, Javier Lopez Prieto, Jongyoon Han, Lidan Wu
-
Patent number: 9709479Abstract: A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtiter plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.Type: GrantFiled: October 24, 2014Date of Patent: July 18, 2017Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Marc Castellarnau, Gregory Lee Szeto, Darrell J. Irvine, John Christopher Love, Joel Voldman
-
Patent number: 9605253Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.Type: GrantFiled: January 14, 2014Date of Patent: March 28, 2017Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Joel Voldman, Thibault Honegger, David Peyrade
-
Patent number: 9605254Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.Type: GrantFiled: January 14, 2014Date of Patent: March 28, 2017Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Joel Voldman, Thibault Honegger, David Peyrade
-
Publication number: 20170065976Abstract: Endothelial cells can become susceptible to disease when subjected to disturbed (atheroprone) blood flow patterns, which naturally occur in known locations in human arteries. Atheroprone flow is non-laminar, with low fluid shear stress magnitude and an oscillatory pattern representative in the temporal signature. At a macro-scale, atheroprone flow is multidirectional and chaotic. On the other hand, atheroprotective flow is laminar with high fluid shear stresses that have a specific temporal signature. Therefore, understanding the interplay between the atheroprotective and atheroprone hemodynamics and endothelial function is important. The invention relates, in some embodiments, to microfluidic devices and methods that dynamically apply controlled and physiologically relevant spatio-temporal atheroprone and atheroprotective flow signatures.Type: ApplicationFiled: September 9, 2016Publication date: March 9, 2017Inventors: Sarvesh Varma, Joel Voldman
-
Publication number: 20160331297Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.Type: ApplicationFiled: January 16, 2015Publication date: November 17, 2016Inventors: Joel Voldman, Hao-Wei Su, Javier Lopez Prieto, Jongyoon Han, Lidan Wu
-
Patent number: 9201060Abstract: The present invention provides a device and methods of use thereof in microscale particle capturing and particle pairing. This invention provides particle patterning device, which mechanically traps individual particles within first chambers of capture units, transfer the particles to second chambers of opposing capture units, and traps a second type of particle in the same second chamber. The device and methods allow for high yield assaying of trapped cells, high yield fusion of trapped, paired cells, for controlled binding of particles to cells and for specific chemical reactions between particle interfaces and particle contents. The device and method provide means of identification of the particle population and a facile route to particle collection.Type: GrantFiled: February 11, 2009Date of Patent: December 1, 2015Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Joel Voldman, Alison M. Skelley, Oktay Kirak, Rudolf Jaenisch
-
Publication number: 20150253237Abstract: A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtitre plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.Type: ApplicationFiled: October 24, 2014Publication date: September 10, 2015Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Marc Castellarnau, Gregory Lee Szeto, Darrell J. Irvine, John Christopher Love, Joel Voldman
-
Publication number: 20140199745Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.Type: ApplicationFiled: January 14, 2014Publication date: July 17, 2014Applicants: Centre National de la Recherche Scientifique, Massachusetts Institute of TechnologyInventors: Joel Voldman, Thibault Honegger, David Peyrade
-
Publication number: 20140199746Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.Type: ApplicationFiled: January 14, 2014Publication date: July 17, 2014Applicants: Centre National de la Recherche Scientifique, Massachusetts Institute of TechnologyInventors: Joel Voldman, Thibault Honegger, David Peyrade
-
Patent number: 8691151Abstract: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.Type: GrantFiled: August 27, 2007Date of Patent: April 8, 2014Assignee: Massachusetts Institute of TechnologyInventors: Joseph Kovac, Joel Voldman
-
Publication number: 20140093911Abstract: A method of predictive identification and separation of high-performing cells from a mixed population of cells includes distributing cells belonging to the mixed population to a plurality of open chambers; identifying open chambers containing desired cells and open chambers containing undesired cells; selectively sealing at least one open chamber containing undesired cells; and recovering the desired cells from the open chambers. Cells can be predictively assigned as desired or undesired based on an automated image analysis algorithm.Type: ApplicationFiled: September 28, 2012Publication date: April 3, 2014Inventors: Tao Sun, Joel Voldman
-
Patent number: 8454813Abstract: The present invention provides a device and methods of use thereof in microscale cell sorting. This invention provides sorting cytometers, which trap individual cells within vessels following exposure to dielectrophoresis, allow for the assaying of trapped cells, such that a population is identified whose isolation is desired, and their isolation.Type: GrantFiled: April 24, 2008Date of Patent: June 4, 2013Assignee: Massachusetts Institute of TechnologyInventors: Joel Voldman, Brian Michael Taff
-
Patent number: 8021877Abstract: This invention provides devices comprising substrates with wells for the patterning of particles or cells. Such devices are loaded with a suspension of particles or cell, and the entrapped particles or cells are transferred to a second substrate, where patterning of individual particles or cells occurs. Methods of cellular analysis, cell growth studies, surface modification, optical display fabrication and curved surface patterning using devices of this invention are described.Type: GrantFiled: April 10, 2006Date of Patent: September 20, 2011Assignee: Massachusetts Institute of TechnologyInventors: Adam Rosenthal, Joel Voldman
-
Publication number: 20110045994Abstract: The present invention provides a device and methods of use thereof in microscale particle capturing and particle pairing. This invention provides particle patterning device, which mechanically traps individual particles within first chambers of capture units, transfer the particles to second chambers of opposing capture units, and traps a second type of particle in the same second chamber. The device and methods allow for high yield assaying of trapped cells, high yield fusion of trapped, paired cells, for controlled binding of particles to cells and for specific chemical reactions between particle interfaces and particle contents. The device and method provide means of identification of the particle population and a facile route to particle collection.Type: ApplicationFiled: February 11, 2009Publication date: February 24, 2011Inventors: Joel Voldman, Alison M. Skelley, Oktay Kirak, Rudolf Jaenisch
-
Publication number: 20090294291Abstract: The present invention is directed to an iso-dielectric separation apparatus for separating particles based upon their electrical properties, and methods of using the apparatus.Type: ApplicationFiled: November 15, 2006Publication date: December 3, 2009Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Joel Voldman, Michael Vahey