Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A motorized self-balancing vehicle is provided. The vehicle may include at least two wheels. The vehicle may include a self-balancing mechanism. The vehicle may include a manual-drive mechanism. The self-balancing mechanism may constantly update the self-balancing vehicle in order to maintain the balance of a rider of the vehicle, while the rider is engaged in human motion on the manual-drive mechanism. The human motion may include pedaling and/or stepping. The vehicle may include an electric motor. The vehicle may include only an electric motor. The vehicle may include only a manual-drive mechanism. The vehicle may include both the manual-drive mechanism and the electric motor. In the embodiment including the manual-drive mechanism and the electric motor, the power generated by the electronic motor may be combined with power generated by the manual-drive mechanism in order to move the vehicle.

Abstract: A motorized self-balancing vehicle is provided. The vehicle may include at least two wheels. The vehicle may include a self-balancing mechanism. The vehicle may include a manual-drive mechanism. The self-balancing mechanism may constantly update the self-balancing vehicle in order to maintain the balance of a rider of the vehicle, while the rider is engaged in human motion on the manual-drive mechanism. The human motion may include pedaling and/or stepping. The vehicle may include an electric motor. The vehicle may include only an electric motor. The vehicle may include only a manual-drive mechanism. The vehicle may include both the manual-drive mechanism and the electric motor. In the embodiment including the manual-drive mechanism and the electric motor, the power generated by the electronic motor may be combined with power generated by the manual-drive mechanism in order to move the vehicle.

Abstract: A motorized self-balancing vehicle is provided. The vehicle may include at least two wheels. The vehicle may include a self-balancing mechanism. The vehicle may include a manual-drive mechanism. The self-balancing mechanism may constantly update the self-balancing vehicle in order to maintain the balance of a rider of the vehicle, while the rider is engaged in human motion on the manual-drive mechanism. The human motion may include pedaling and/or stepping. The vehicle may include an electric motor. The vehicle may include only an electric motor. The vehicle may include only a manual-drive mechanism. The vehicle may include both the manual-drive mechanism and the electric motor. In the embodiment including the manual-drive mechanism and the electric motor, the power generated by the electronic motor may be combined with power generated by the manual-drive mechanism in order to move the vehicle.

Abstract: The colostomy balloon plug has three parallel conduits with a combined charcoal and hydrophobic filter at one end of the largest central first conduit. The largest central first conduit is open at one end and has the combined charcoal and hydrophobic filter at its other end, for elimination of bowel gas. A shorter parallel second conduit terminates on one end in a first balloon and on a second end in a first one-way valve. A shortest parallel third conduit terminates on one end in a second balloon and on a second end in a second one-way valve. A syringe and extension conduit is selectively attached to the two one-way valves. Air, saline solution or sterilized water can be introduced from the syringe through the one-way valves of the extension conduit to inflate the two balloons about the largest central first conduit. The one-way valves prevent deflation of the balloons unless the shorter or shortest parallel conduits are cut to allow the fluid from the two balloons to exit and deflate the balloons.

Abstract: Commission allocations in transaction management of auction-based trading for specialized items such as fixed income instruments. A plurality of workstations that are connected to a server, and a structured commission allocation protocol may be provided. Through the workstations, the server and the commission allocation protocol, the systems and methods may allocate commissions or fees when trading securities at accelerated levels with minimal errors and costs, control commission elements during real-time trading, reward customers and brokers who participate in transactions, and distribute commission and transaction data in real time.

Abstract: The colostomy balloon plug has three parallel conduits with a combined charcoal and hydrophobic filter at one end of the largest central first conduit. The largest central first conduit is open at one end and has the combined charcoal and hydrophobic filter at its other end, for elimination of bowel gas. A shorter parallel second conduit terminates on one end in a first balloon and on a second end in a first one-way valve. A shortest parallel third conduit terminates on one end in a second balloon and on a second end in a second one-way valve. A syringe and extension conduit is selectively attached to the two one-way valves. Air, saline solution or sterilized water can be introduced from the syringe through the one-way valves of the extension conduit to inflate the two balloons about the largest central first conduit. The one-way valves prevent deflation of the balloons unless the shorter or shortest parallel conduits are cut to allow the fluid from the two balloons to exit and deflate the balloons.

Abstract: Apparatus for electronically notifying an individual of an incomplete transaction associated with a received correspondence item is provided. The apparatus may include a receiver for receiving a single paper correspondence item associated with a first correspondence. The apparatus may include a processor for deriving a digital image from the paper correspondence item. The processor may be configured to determine, based on the derived digital image, whether the correspondence item is a paper check. In response to the determination of the correspondence item as a paper check, the processor may be further configured to use a real-time notification channel to notify the individual of receipt of the paper check. The notification may be based, at least in part, on the identification of the individual. The processor may be further configured to use the real-time notification channel to present at least one option for identification of an account to which the check should be applied.

Abstract: Apparatus and methods for an enhanced cash withdrawal transaction option are provided. The enhanced cash withdrawal transaction option may include using an ATM to display an initial ATM display. The initial ATM display may display multiple transaction options, the multiple transaction options including at least one cash withdrawal amount. Apparatus and methods for an additional enhanced cash withdrawal transaction are provided. The additional enhanced cash withdrawal transaction may enable a user to type an ATM PIN in an ATM keypad followed by a cash withdrawal amount. Apparatus and methods for an enhanced ATM customer display are also provided. The enhanced ATM customer display according to the systems and methods of the invention may customize an ordered ATM customer flow based on historical customer usage data.

Abstract: Apparatus and methods for an enhanced cash withdrawal transaction option are provided. The enhanced cash withdrawal transaction option may include using an ATM to display an initial ATM display. The initial ATM display may display multiple transaction options, the multiple transaction options including at least one cash withdrawal amount. Apparatus and methods for an additional enhanced cash withdrawal transaction are provided. The additional enhanced cash withdrawal transaction may enable a user to type an ATM PIN in an ATM keypad followed by a cash withdrawal amount. Apparatus and methods for an enhanced ATM customer display are also provided. The enhanced ATM customer display according to the systems and methods of the invention may customize an ordered ATM customer flow based on historical customer usage data.

Abstract: Commission allocations in transaction management of auction-based trading for specialized items such as fixed income instruments. A plurality of workstations that are connected to a server, and a structured commission allocation protocol may be provided. Through the workstations, the server and the commission allocation protocol, the systems and methods may allocate commissions or fees when trading securities at accelerated levels with minimal errors and costs, control commission elements during real-time trading, reward customers and brokers who participate in transactions, and distribute commission and transaction data in real time.

Abstract: Apparatus and methods for an enhanced cash withdrawal transaction option are provided. The enhanced cash withdrawal transaction option may include using an ATM to display an initial ATM display. The initial ATM display may display multiple transaction options, the multiple transaction options including at least one cash withdrawal amount. Apparatus and methods for an additional enhanced cash withdrawal transaction are provided. The additional enhanced cash withdrawal transaction may enable a user to type an ATM PIN in an ATM keypad followed by a cash withdrawal amount. Apparatus and methods for an enhanced ATM customer display are also provided. The enhanced ATM customer display according to the systems and methods of the invention may customize an ordered ATM customer flow based on historical customer usage data.

Abstract: The single use catheter has a lumen with a hydrophobic filter tip at one end. The lumen is divided into two parallel conduits. A first conduit terminates in a one-way valve. A syringe is attached to the one-way valve. Air, saline solution or sterilized water can be introduced through the one-way valve and inflate a cuff about the lumen. The second parallel conduit terminates in a charcoal filter for elimination of bowel gas. The one-way valve prevents deflation of the cuff unless the lumen is cut to allow the fluid from the cuff to exit and deflate the cuff.

Abstract: Provided herein are methods for identifying a cancer patient responsive to treatment with an EGFR tyrosine kinase inhibitor. One method comprises obtaining a biopsy from the patient and measuring the number of copies of miR-128b in DNA extracted from the biopsy. A patient responsive to EGFR tyrosine kinase inhibitor treatment has a cancer with less than two copies of miR-128b DNA. Another method comprises measuring miR-128b or miR-128a level in a biopsy obtained from the patient and comparing that level to miR-128b or miR-128a level in a normal tissue sample. A patient responsive to treatment with an EGFR tyrosine kinase inhibitor has a cancer expressing a lower level of miR-128b or miR-128a relative to normal tissue. Further provided herein are methods for treating cancer in a patient in need thereof. One method comprises measuring the level of miR-128b or miR-128a in a biopsy obtained from the patient and administering to the patient an EGFR tyrosine kinase inhibitor.

Abstract: Commission allocations in transaction management of auction-based trading for specialized items such as fixed income instruments. A plurality of workstations that are connected to a server, and a structured commission allocation protocol may be provided. Through the workstations, the server and the commission allocation protocol, the systems and methods may allocate commissions or fees when trading securities at accelerated levels with minimal errors and costs, control commission elements during real-time trading, reward customers and brokers who participate in transactions, and distribute commission and transaction data in real time.

Abstract: The present invention is related to systems and methods for implementing commission allocations in transaction management of auction-based trading for specialized items such as interest-rate-related instruments. In accordance with these systems and methods, a plurality of workstations that are connected to a server, and a structured commission allocation protocol may be provided. Through the workstations, the server, and the commission allocation protocol, the systems and methods may allocate commissions or fees when trading securities at accelerated levels with minimal errors and costs, control commission elements during real-time trading, and distribute commission and transaction data in real time.

Abstract: Thus, systems and methods providing sub-dressing wound analysis and therapy are provided. One embodiment of the invention may include a treatment system including a wound dressing comprising perforations. The system may also include a light receptor and an excitation light source. When the wound dressing is deployed on a wound, the light source may provide light that propagates through the wound and is detectable via the perforations. Furthermore, the light receptor may be configured to receive the transmitted light. The transmitted light may include information relating to the viability of tissue within the wound.

Abstract: A granular magnetic recording medium comprises a non-magnetic substrate having a surface, a layer stack on the substrate surface, including an outermost granular magnetic recording layer, a cap layer on the granular magnetic recording layer, having a sputter-etched outer surface, and a protective overcoat layer on the sputter-etched outer surface of the cap layer.

Abstract: A method for making substrates is disclosed. The method comprises providing a rod, which is made out of a substrate material and has an outside diameter substantially the same size as the outside diameter of a finished substrate and an inside diameter substantially the same size as the inside diameter of the finished substrate. The rod is cut with a multi-wire cutter to make a substrate slice substantially the same size as a finished substrate. The multi-wire cutter has wires positioned to substantially match the final thickness of the finished substrate. Additionally the cutting process is facilitated by using slurry and by providing a rocking motion between the rod and the wires of the multi-wire cutter so that the wires contact the rod in a rocking motion with respect to a normal to the center of the rod.