Patents by Inventor Joelle Chabry

Joelle Chabry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of formation of protease resistant prion protein
    Patent number: 6355610
    Abstract: Peptides are disclosed that inhibit the conversion of protease sensitive prion protein (PrPsen) to the protease resistant isoform (PrPres). These peptides comprise discrete fragments of prion proteins, and are shown to inhibit the in vitro conversion of PrPsen to PrPres in a cell-free system. Numerous peptides are disclosed that include at least two amino acid residues from the highly amyloidogenic region P113-120 of the PrP protein. None of these peptides conferred protease-resistance to the PrPsen molecules. The presence of residues 119 and 120 from the highly hydrophobic sequence AGAAAAGA (position 113 to 120) produced a particular inhibitory effect. The inhibition occurred with a high degree of specificity (e.g. with an IC50 of less than about 1000 &mgr;M).
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: March 12, 2002
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: Bruce W. Chesebro, Byron W. Caughey, Joelle Chabry, Suzette Priola
  • Inhibitors of formation of protease resistant prion protein
    Publication number: 20010041790
    Abstract: Peptides are disclosed that inhibit the conversion of protease sensitive prion protein (PrPsen) to the protease resistant isoform (PrPres). These peptides comprise discrete fragments of prion proteins, and are shown to inhibit the in vitro conversion of PrPsen to PrPres in a cell-free system. Numerous peptides are disclosed that include at least two amino acid residues from the highly amyloidogenic region P113-120 of the PrP protein. None of these peptides conferred protease-resistance to the PrPsen molecules. The presence of residues 119 and 120 from the highly hydrophobic sequence AGAAAAGA (position 113 to 120) produced a particular inhibitory effect. The inhibition occurred with a high degree of specificity (e.g. with an IC50 of less than about 1000 &mgr;M).
    Type: Application
    Filed: March 30, 2001
    Publication date: November 15, 2001
    Applicant: Government of the U.S. of America, Secretary of the Department of Health and Human Services
    Inventors: Bruce W. Chesebro, Byron W. Caughey, Joelle Chabry, Suzette Priola
  • Inhibitors of formation of protease resistant prion protein
    Patent number: 6211149
    Abstract: Peptides are disclosed that inhibit the conversion of protease sensitive prion protein (PrPsen) to the protease resistant isoform (PrPres). These peptides comprise discrete fragments of prion proteins, and are shown to inhibit the in vitro conversion of PrPsen to PrPres in a cell-free system. Numerous peptides are disclosed that include at least two amino acid residues from the highly amyloidogenic region P113-120 of the PrP protein. None of these peptides conferred protease-resistance to the PrPsen molecules. The presence of residues 119 and 120 from the highly hydrophobic sequence AGAAAAGA (position 113 to 120) produced a particular inhibitory effect. The inhibition occurred with a high degree of specificity (e.g. with an IC50 of less than about 1000 &mgr;M).
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: April 3, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bruce W. Chesebro, Byron W. Caughey, Joelle Chabry, Suzette Priola